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Human HDAC5 ELISA Kit für Sandwich ELISA - ABIN420524
Alam, Rashid, Kabir, Raqib, Ahmad: On birth single dose live attenuated OPV and BCG vaccination induces gut cathelicidin LL37 responses at 6 week of age: a natural experiment. in Vaccine 2014
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HDAC5 is a negative predictor of disease-free and overall survival in pancreatic neuroendocrine tumor patients.
Interference with both glucose and glutamine (zeige GFPT1 ELISA Kits) supply in HDAC5-inhibited cancer cells significantly increases apoptotic cell death.
these results suggest that HDAC5 is critical in regulating LSD1 (zeige KDM1A ELISA Kits) protein stability through post-translational modification, and the HDAC5-LSD1 (zeige KDM1A ELISA Kits) axis has an important role in promoting breast cancer development and progression.
The expression of HDAC5 was significantly increased in endothelial cells (ECs) from patients with systemic sclerosis (SSc (zeige CYP11A1 ELISA Kits)) compared to healthy control endothelial cells. Silencing of HDAC5 in SSc (zeige CYP11A1 ELISA Kits) ECs restored normal angiogenesis. HDAC5 knockdown followed by ATAC (zeige XCL1 ELISA Kits)-seq assay in SSc (zeige CYP11A1 ELISA Kits) ECs identified key HDAC5-regulated genes involved in angiogenesis and fibrosis, such as CYR61 (zeige CYR61 ELISA Kits), PVRL2 (zeige PVRL2 ELISA Kits), and FSTL1 (zeige FSTL1 ELISA Kits).
the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 (zeige HIPK2 ELISA Kits) in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5-homeodomain-interacting protein kinase-2 (zeige HIPK2 ELISA Kits)-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.
HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.
HDAC5 promotes cellular proliferation through the upregulation of cMet, and may provide a novel therapeutic target for the treatment of patients with Wilms' tumor.
HDAC5 and HDAC6 (zeige HDAC6 ELISA Kits) were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.
Formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT (zeige ITK ELISA Kits) through inhibition of HDAC5.
These results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages.
HDAC6 (zeige HDAC6 ELISA Kits) inhibition reduces cell growth primarily by reducing intracellular cAMP and Ca(2 (zeige CA2 ELISA Kits)+) levels.
These data thus reveal that HDAC6 (zeige HDAC6 ELISA Kits) represses IL-17 (zeige IL17A ELISA Kits) production in T cells, providing novel insights into the role of HDAC6 (zeige HDAC6 ELISA Kits) in the immune system.
A decrease of HDAC6 (zeige HDAC6 ELISA Kits) expression caused by Helicobacter pylori infection is associated with oncogenic transformation in gastric cancer.
HDAC5 emerges as a cellular conductor of MEF2C (zeige MEF2C ELISA Kits) and M6a (zeige GPM6A ELISA Kits) activity and is regulated by miR (zeige MLXIP ELISA Kits)-124 and miR (zeige MLXIP ELISA Kits)-9 to control neurite development.
HDAC6 (zeige HDAC6 ELISA Kits) inhibition reduces tumor growth and PD-L1 (zeige CD274 ELISA Kits) production in vivo.
Specific HDAC6 (zeige HDAC6 ELISA Kits) inhibitor, tubacin, reduced cyst growth by inhibiting proliferation of cyst-lining epithelial cells, downregulated cyclic AMP (zeige TMPRSS5 ELISA Kits) levels, and improved renal function in mouse model of autosomal dominant polycystic kidney disease (ADPKD). Thus, HDAC6 (zeige HDAC6 ELISA Kits) could play a role in cyst formation and could serve as a potential therapeutic target in ADPKD.
Data suggest that a switch in post-translational processing of Tau from acetylation at Lys321 to phosphorylation at Ser324 coordinately regulates Tau aggregation and may be relevant in tauopathy and Alzheimer disease; acetylation/phosphorylation of Tau appears to be controlled by Hdac6 (histone deacetylase 6 (zeige HDAC6 ELISA Kits) protein).
ARID1A (zeige ARID1A ELISA Kits) mutation inactivates the apoptosis-promoting function of p53 (zeige TP53 ELISA Kits) by upregulating HDAC6 (zeige HDAC6 ELISA Kits), indicating that pharmacological inhibition of HDAC6 (zeige HDAC6 ELISA Kits) is a therapeutic strategy for ARID1A (zeige ARID1A ELISA Kits)-mutated cancers.
Fatty acids prevent CIDEC (zeige CIDEC ELISA Kits) deacetylation by promoting the dissociation of CIDEC (zeige CIDEC ELISA Kits) from HDAC6 (zeige HDAC6 ELISA Kits), resultin in increased association of CIDEC (zeige CIDEC ELISA Kits) with PCAF (zeige KAT2B ELISA Kits) on the endoplasmic reticulum.
findings showed that CAMDI regulates neuronal migration through the modulation of HDAC6 and indicate that HDAC6 hyperactivation by CAMDI deletion causes psychiatric behaviors, at least in part, through delayed radial migration due to impaired centrosomes
Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis
Regulation of flowering time by the histone deacetylase HDA5
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 5
, antigen NY-CO-9
, histone deacetylase 4
, histone deacetylase mHDA1
, histone deacetylase mHDA2
, scurfy candidate 6