CLEC2D Proteine (CLEC2D)

Bezeichnung:
C-Type Lectin Domain Family 2, Member D Proteine (CLEC2D)
Auf www.antikoerper-online.de finden Sie aktuell 10 C-Type Lectin Domain Family 2, Member D (CLEC2D) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CLEC2D Antikörper (65) und CLEC2D Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 84 CLEC2D Produkte verfügbar.
Synonyme:
B-LEC, Blec, Blec1, CLAX, CLEC2D, Clec2d5, Clr-b, Clrb, LLT1, OCIL
alle Proteine anzeigen Gen GeneID UniProt
CLEC2D 93694 Q91V08
CLEC2D 29121 Q9UHP7
CLEC2D 113937 Q925N7

Weitere Synonyme anzeigen

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Am meisten referenzierte CLEC2D Proteine

  1. Human CLEC2D Protein expressed in Escherichia coli (E. coli) - ABIN1098758 : Hu, Zhou, Myers, Quinn, Atkins, Ly, Gange, Kartsogiannis, Elliott, Kostakis, Zannettino, Cromer, McKinstry, Findlay, Gillespie, Ng: Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004 (PubMed)
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Weitere Proteine zu CLEC2D Interaktionspartnern

Mouse (Murine) C-Type Lectin Domain Family 2, Member D (CLEC2D) Interaktionspartner

  1. Data suggest that killer cell lectin-like receptors NKR (zeige TACR3 Proteine)-P1B:Clr-b (Klrb1 (zeige KLRB1 Proteine):Clec2d) interactions may provide a model for human hematopoietic cell transplants.

  2. Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.

  3. LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (zeige IFNG Proteine) contributes to modulate immune responses

  4. cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.

  5. Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.

  6. Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.

  7. OCIL is a physiological negative regulator of bone.

  8. PTHrp(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (zeige CA2 Proteine)+)/CaMK II (zeige CAMK2B Proteine), and MAPK (zeige MAPK1 Proteine) signaling pathways.

  9. Identification of a novel family of genes, named Clr (zeige CALCR Proteine), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.

  10. Mouse Nkrp1d and Nkrp1f (zeige KLRB1F Proteine) bind specific C-type lectin-related (Clr (zeige CALCR Proteine)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (zeige CALCR Proteine) are intertwined in a genetically conserved NKC region.

Human C-Type Lectin Domain Family 2, Member D (CLEC2D) Interaktionspartner

  1. these data suggest that LLT1-CD161 (zeige KLRB1 Proteine) interactions play a novel and important role in B cell maturation (zeige TNFRSF17 Proteine) within the Germinal center in humans.

  2. In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.

  3. The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (zeige MBL2 Proteine)-like proteins in the glycosylated form.

  4. One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)

  5. LLT1 and CD161 (zeige KLRB1 Proteine) have roles in modulating immune responses to pathogens; and interferon-gamma (zeige IFNG Proteine) contributes to modulate immune responses

  6. Molecular basis for LLT1 protein recognition by human CD161 (zeige KLRB1 Proteine) protein (NKRP1A/KLRB1 (zeige KLRB1 Proteine)).

  7. Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.

  8. LLT1 used Src (zeige SRC Proteine)-PTK, p38 (zeige CRK Proteine) and ERK (zeige EPHB2 Proteine) signalling pathways, but not PKC (zeige PRRT2 Proteine), PI3K (zeige PIK3CA Proteine) or calcineurin (zeige PPP3CA Proteine) pathways, to increase production of IFN-gamma (zeige IFNG Proteine) by human natural killer cells.

  9. LLT1 induces Interferon (zeige IFNA Proteine) Type II production by natural killer cells.

  10. Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells [OCIL].

CLEC2D Protein Überblick

Protein Überblick

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.

Alternative names and synonyms associated with CLEC2D

  • C-type lectin domain family 2, member D (CLEC2D)
  • C-type lectin domain family 2, member d (Clec2d)
  • C-type lectin domain family 2, member D (Clec2d)
  • B-LEC Protein
  • Blec Protein
  • Blec1 Protein
  • CLAX Protein
  • CLEC2D Protein
  • Clec2d5 Protein
  • Clr-b Protein
  • Clrb Protein
  • LLT1 Protein
  • OCIL Protein

Bezeichner auf Proteinebene für CLEC2D

osteoclast inhibitory lectin , c-type lectin-like receptor , C-type lectin domain family 2, member D , C-type lectin domain family 2 member D , C-type lectin-domain family 2 member D , C-type lectin-related protein B , lectin-like transmembrane protein , C-type lectin related f , C-type lectin superfamily 2, member D , LLT-1 , lectin-like NK cell receptor , lectin-like transcript 1 , C-type lectin domain family 2 member D5

GENE ID SPEZIES
404776 Gallus gallus
617565 Bos taurus
737015 Pan troglodytes
427735 Gallus gallus
93694 Mus musculus
29121 Homo sapiens
611449 Canis lupus familiaris
113937 Rattus norvegicus
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