Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
A Disc1 peptide binds to GSK3beta (zeige GSK3b ELISA Kits), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (zeige CTNNB1 ELISA Kits)-mediated Wnt (zeige WNT2 ELISA Kits) signaling and inhibiting GSK3beta (zeige GSK3b ELISA Kits) activity.
Disc1 and nrg1 (zeige NRG1 ELISA Kits) function in controlling development of oligodendrocytes and neurones from olig2 (zeige OLIG2 ELISA Kits)-expressing precursor cells.
Disc1 functions in the transcriptional repression of foxd3 (zeige FOXD3 ELISA Kits) and sox10 (zeige SOX10 ELISA Kits), thus mediating cranial neural crest cell migration and differentiation.
Study reports sex-specific influence of common disrupted-in-schizophrenia-1 variants on volumes of the basal ganglia, the amygdala and on the cortical surface area.
Study found a significant association between the DISC1 gene polymorphism rs6675281 alone, and the combination of rs6675281 and rs821616, and differences in long-term cortical thickness growth in patients with a first-episode of psychosis; and observed an overall difference in cortical thickness, as well as heightened disparities in the frontal and temporal brain regions.
HTT (zeige HTT ELISA Kits) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (zeige PDE4A ELISA Kits)) to regulate PDE4 (zeige PDE4A ELISA Kits) activity.
This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.
Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (zeige CHL1 ELISA Kits) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.
DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.
Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (zeige GSK3b ELISA Kits) phosphorylation.
DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations
These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses
This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (zeige NRG1 ELISA Kits) genes could be associated with schizophrenia in the Chinese population.
DISC1 in association with SNPH (zeige SNPH ELISA Kits) is a component of a modulatory complex that determines mitochondrial anchoring in response to neuronal activation.
the existence of abnormal synaptic transmission and plasticity in hippocampal network may disrupt declarative information processing and contribute to recognition deficits in DISC1 L100P mutant mice.
Co-disruption of DISC1 and NRG1 (zeige NRG1 ELISA Kits), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (zeige AVP ELISA Kits) gene expression in a mouse schizophrenia model.
the 100P mutation in Disc1 prevents expression of parvalbumin (zeige PVALB ELISA Kits) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (zeige PVALB ELISA Kits) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.
mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons
abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.
Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (zeige GSK3b ELISA Kits) signaling and sex-dependent behavioral effects in mice
Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.
Hypoxic preconditioning decreases NF-kappaB (zeige NFKB1 ELISA Kits) activity via Disc1.
Results indicate that DISC1 attenuates Abeta (zeige APP ELISA Kits) generation and cognitive deficits of APP (zeige APP ELISA Kits)/PS1 (zeige PSEN1 ELISA Kits) transgenic mice through promoting lysosomal degradation of BACE1 (zeige BACE ELISA Kits)
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
disrupted in schizophrenia 1 protein
, disrupted in schizophrenia 1
, disrupted in schizophrenia 1 homolog