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Data show OCILRP2 binding to DAP12 (zeige TYROBP Proteine) resulting in Raf (zeige RAF1 Proteine)-MAP kinase (zeige MAPK1 Proteine) pathways activation and T-cell activation.
OCILRP2 is a regulator of dendritic cells maturation and differentiation following TLR4 (zeige TLR4 Proteine) activation.
The electrostatic profile of NKR-P1F (zeige KLRB1F Proteine) is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential.
studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f (zeige KLRB1F Proteine), during APC (zeige APC Proteine)-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo
Identification of a novel family of genes, named Clr (zeige CALCR Proteine), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
mouse Nkrp1d and Nkrp1f (zeige KLRB1F Proteine) bind specific C-type lectin-related (Clr (zeige CALCR Proteine)) molecules. Nkrp1d mediated inhibition when recognizing Clrb (zeige CLEC2D Proteine), a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (zeige CALCR Proteine) are intertwined in a genetically conserved NKC region.
Inhibits osteoclast formation. Receptor for KLRB1F. Enhances T-cell activation. Plays a role in splenocyte activation, T-cell responses and IL-2 production.
C-type lectin 1
, C-type lectin domain family 2 member I
, C-type lectin-related protein DCL1
, C-type lectin-related protein G
, lymphoid-derived C-type lectin-1
, ocil-related protein 2
, osteoclast inhibitory lectin related protein 2
, osteoclast inhibitory lectin-related protein 2