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Mean eotaxin 2 concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects.
Review: eotaxins (CCL11, CCL24, and CCL26 (zeige CCL26 Proteine)) play key role(s) during symptomatic inflammatory responses raised in response to allergic crisis of allergic asthma and atopic dermatitis
HMGB1 (zeige HMGB1 Proteine) did not elicit chemotaxis of human eosinophils alone and had no effect in combination with the eosinophil chemotactic agent, eotaxin-2 (CCL24).
these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family.
CCL11, CCL24, and CCL26 (zeige CCL26 Proteine) are increased in TB patients; hence, it seems that TB suppresses Th1 (zeige TH1L Proteine) and the classic function of macrophages subsequently by inducing the chemokines' expression
CCL11, CCL24, and CCL26 (zeige CCL26 Proteine) has a role in the recruitment of extravillous trophoblast into decidual tissue and vessels.
Pregnancy associated environments increased local CCL24/CCR3 (zeige CCR3 Proteine), supporting the process of decidualization in human early pregnancy.
Phosphodiesterase 4 inhibitors, rolipram and RO-20-1724 have no effect on CCL24 expression in human primary bronchial epithelial cells.
The level of eotaxin expression and inflammatory cell count were measured in the material from nasal brushing in healthy controls and in patients with allergic rhinitis, asthma, and chronic obstructive pulmonary disease.
Study shows that CCL24 levels were significantly increased in age-related macular degeneration (AMD (zeige AMD1 Proteine)) patients despite Avastin treatment as compared with normal controls and those without Avastin.
the increased airway eosinophils and mucous cell metaplasia in house dust mite-challenged Cd163 (zeige CD163 Proteine)-/- mice are mediated by augmented CCL24 production
TPL-2 (zeige MAP3K8 Proteine)-regulated Ccl24 in CD11c (zeige ITGAX Proteine)+CD11b (zeige ITGAM Proteine)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
this study shows that TPL-2 (zeige MAP3K8 Proteine) inhibits Ccl24 expression in lung dendritic cells, and blockade of Ccl24 prevents the exaggerated airway eosinophilia and lung inflammation in mice given house dust mites-pulsed Map3k8 (zeige MAP3K8 Proteine)-/- dendritic cells
production in M-CSF (zeige CSF1R Proteine)-induced bone marrow-derived macrophages is synergistically induced by IL-4 (zeige IL4 Proteine) and IL-10 (zeige IL10 Proteine)
Autologous transfer of peritoneal macrophages in to the airways of asthmatic mice reduces eotaxin production.
Data indicate that eotaxin 2 (CCL-24), which is known to influence eosinophil migration, was highly up-regulated in broncho-alveolar macrophages (BAMs).
The oesophageal production of CCL24 upon IL-13 (zeige IL13 Proteine) stimulation is sufficient to promote eosinophil migration.
Results demonstrate a cooperative mechanism between interleukin-13 (zeige IL13 Proteine) and eotaxin-2, where IL-13 (zeige IL13 Proteine) mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13 (zeige IL13 Proteine)-induced airway eosinophilia.
Distinct acidic and basic residues within CCR3 (zeige CCR3 Proteine) determine both receptor expression and activation by the eotaxins.
The eotaxin-2 pathway plays a fundamental role in eosinophil recruitment during ovalbumin (zeige OVA Proteine)-induced experimental asthma.
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line.
C-C motif chemokine 24
, eosinophil chemotactic protein 2
, myeloid progenitor inhibitory factor 2
, small inducible cytokine subfamily A (Cys-Cys), member 24
, small-inducible cytokine A24
, CC chemokine CCL24
, small inducible cytokine A24
, eotaxin-2-like protein
, eosinophil chemotactic protein-2
, small chemokine ligand 24