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APEX1 Protein (AA 1-318) (T7 tag)
APEX1
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 90 % by SDS - PAGE
SDS
Produktdetails
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Target
Alle APEX1 Proteine anzeigen
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Protein-Typ
Recombinant
Proteineigenschaft
AA 1-318
Spezies
Alle Spezies für APEX1 Proteine
Human
Quelle
Alle Expressionssysteme für APEX1 Proteine
Escherichia coli (E. coli)
Aufreinigungstag / Konjugat
Dieses APEX1 Protein ist gelabelt mit T7 tag.
Applikation
SDS-PAGE (SDS)
Produktmerkmale
APEX1, 1-318aa, Human, T7 tag, E.coli
Reinheit
> 90 % by SDS - PAGE
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Alternativen
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Anwendungsinformationen
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Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/ml (determined by Bradford assay)
Buffer
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 10% glycerol
Lagerung
4 °C
Antigendetails
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Target
APEX1
(Apurinic/Apyrimidinic Endonuclease 1 (APEX1))
Andere Bezeichnung
APEX1 (APEX1 Produkte )
Synonyme
apex1 Protein, MGC76280 Protein, MGC79645 Protein, MGC78928 Protein, APE Protein, APE1 Protein, APEN Protein, APEX Protein, APX Protein, HAP1 Protein, REF1 Protein, Apex Protein, REF-1 Protein, BAP1 Protein, apex1a Protein, hm:zehn1532 Protein, wu:fc13d11 Protein, zgc:66204 Protein, Ref-1 Protein, apurinic/apyrimidinic endodeoxyribonuclease 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 Protein, APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog Protein, DNA-(apurinic or apyrimidinic site) lyase Protein, apurinic/apyrimidinic endonuclease 1 Protein, APEX1 Protein, apex1 Protein, apex1.L Protein, CNG03640 Protein, CNH01280 Protein, nth Protein, Spirs_4119 Protein, Palpr_0103 Protein, Apex1 Protein
Hintergrund
APEX1, also known as REF1 or APE1 (Apurinic / apyrimidinic endonuclease), is responsible for the incision of DNA basic sites during base excision repair. It has also been shown to stimulate the DNA binding activity of numerous transcription factors that are involved in cancer promotion and progression. APEX1 is part of the cellular response to oxidative stress and protects cells from the genotoxic and cytotoxic effect of oxidizing agents. Recombinant human APEX1 protein, fused to T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: APEX nuclease (multifunctional DNA repair enzyme) 1, APE, APE1, APEN, APX, HAP1, REF-1, REF1. NCBI no.: AAH19291
Molekulargewicht
36.9 kDa (332aa), confirmed by MALDI-TOF
Pathways
DNA Reparatur , Chromatin Binding , Cell RedoxHomeostasis , Smooth Muscle Cell Migration , Positive Regulation of Response to DNA Damage Stimulus
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