MGC80943 Protein, RAB27A Protein, gs2 Protein, ram Protein, rab27 Protein, MGC89827 Protein, hst18676 Protein, zgc:114135 Protein, GS2 Protein, HsT18676 Protein, RAB27 Protein, RAM Protein, 2210402C08Rik Protein, 2410003M20Rik Protein, 4933437C11Rik Protein, ash Protein, RAB27A, member RAS oncogene family L homeolog Protein, RAB27A, member RAS oncogene family Protein, RAB27A, member RAS oncogene family S homeolog Protein, rab27a.L Protein, RAB27A Protein, rab27a Protein, rab27a.S Protein, Rab27a Protein
Hintergrund
Ras-related protein Rab-27A, also known as RAB27A, belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Also, RAB27A regulates the cytotoxic granule exocytosis and affect T-lymphocyte and macrophage-activation. It is widely expressed with significant expression in pancreatic islets and pituitary tissue, and low expression in brain. Defects in RAB27A cause Griscelli syndrome type 2 (GS2). Recombinant human RAB27A, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: GS2, RAM, RAB27, Ras-related protein Rab-27A GTP-binding protein Ram, HsT18676.MGC117246, Rab-27, RAB27A, member RAS oncogene family, Ras-related protein Rab27A. NCBI no.: NP_899059