PEDF (SERPINF1)
(serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
Protein-Typ
Recombinant
Proteineigenschaft
AA 20-418
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses PEDF Protein ist gelabelt mit His tag.
Sequenz
AA 20-418
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 45.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE).
SERPINF1
Spezies: Rind (Kuh)
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 %
SDS, WB, Imm, PC
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
PBS, pH 7.4
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Target
PEDF (SERPINF1)
(serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1))
EPC-1 Protein, OI12 Protein, OI6 Protein, PEDF Protein, MGC82984 Protein, SERPINF1 Protein, AI195227 Protein, Pedf Protein, Pedfl Protein, Sdf3 Protein, Dmrs91 Protein, zgc:92072 Protein, serpin family F member 1 Protein, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Protein, serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 L homeolog Protein, serine (or cysteine) peptidase inhibitor, clade F, member 1 Protein, SERPINF1 Protein, serpinf1 Protein, serpinf1.L Protein, Serpinf1 Protein
Hintergrund
Erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.