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anti-Human Cyclin A Antikörper:
anti-Mouse (Murine) Cyclin A Antikörper:
anti-Rat (Rattus) Cyclin A Antikörper:
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Cow (Bovine) Monoclonal Cyclin A Primary Antibody für ICC, WB - ABIN3043070
Zhao, Li, Gao, Wang, Yan, Zhan, Liu, Mao, Chen, Wang et al.: Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase kinase 3? (GSK-3?) ... in European journal of medicinal chemistry 2014
Show all 5 Pubmed References
Human Polyclonal Cyclin A Primary Antibody für ICC, IF - ABIN441337
Pan, Nakade, Huang, Zhu, Masuzaki, Hasegawa, Murata, Yoshiki, Yamaguchi, Lee, Yang, Tsai, Obata, Yokoyama: Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. in Oncogene 2010
Show all 2 Pubmed References
Human Polyclonal Cyclin A Primary Antibody für IF (p), IHC (p) - ABIN670281
Zhang, Pan, Xu, Niu, Ma, Xu: Interleukin 18 augments growth ability via NF-?B and p38/ATF2 pathways by targeting cyclin B1, cyclin B2, cyclin A2, and Bcl-2 in BRL-3A rat liver cells. in Gene 2015
Human Polyclonal Cyclin A Primary Antibody für ChIP, ICC - ABIN4301457
Mazurek, Luo, Krasnitz, Hicks, Powers, Stillman: DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. in Cancer discovery 2012
Findings suggest that ERK1/2 (zeige MAPK1/3 Antikörper)-mediated Cdk2 (zeige CDK2 Antikörper)/cyclin A signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.
some cancer cells are defective for efficient interaction between p27 (zeige PAK2 Antikörper) and CycA-CDK (zeige CDK4 Antikörper) complex due to qualitative alteration(s)
This study shows that cocaine induces significant increases in both the astrocytic expression of cyclin A2 and the proliferation of primary human astrocytes.
Low CCNA expression is associated with lung cancer progression.
cyclin D1 (zeige CCND1 Antikörper) and other cyclins such as cyclin A regulates DNA integrity through RAD51 (zeige RAD51 Antikörper) interaction with the BRCA2 (zeige BRCA2 Antikörper) C-terminal domain
inhibition of PDK4 (zeige PDK4 Antikörper) activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 Antikörper), cyclin A2, and E2F1 (zeige E2F1 Antikörper) proteins.
An increase of cyclin A2 expression was identified for the first time in a case of splenic diffuse red pulp small B-cell lymphoma.
Consistent with these findings, a genome-scale pooled RNA interference screen revealed that toxic doses of MK-1775 are suppressed by CDK2 (zeige CDK2 Antikörper) or Cyclin A2 knockdown. These findings support G2 exit as the more significant effect of Wee1 (zeige WEE1 Antikörper) inhibition in pancreatic cancers.
Clioquinol suppressed cell cycle progression in the S-phase in SMMC-7721 hepatoma cells via the p21 (zeige CDKN1A Antikörper), p27 (zeige PAK2 Antikörper)-cyclin E (zeige CCNE1 Antikörper),A/Cdk2 (zeige CDK2 Antikörper) pathway.
On analyzing cyclin A and B1 (CCNA and CCNB1 (zeige CCNB1 Antikörper)) expression, positive staining in 90% cases of PTC (zeige F9 Antikörper) were observed. The study revealed a significant difference in expression of cyclins A and B1 between classic and non-classic variants of PTC (zeige F9 Antikörper).
We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice.
cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle.
These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis.
Meioc-deficient spermatocytes that have initiated synapsis mis (zeige AMH Antikörper)-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program.
cyclin A2 controlled Mre11 (zeige MRE11A Antikörper) abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 (zeige MRE11A Antikörper) transcripts to mediate polysome loading and translation.
hese data suggest that mmu-miR (zeige MLXIP Antikörper)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K (zeige EEF2K Antikörper) and CCNA2 expression.
Cyclin A2 modulates epithelial-mesenchymal transition via beta-catenin (zeige CTNNB1 Antikörper) and phospholipase C (zeige PLC Antikörper) pathways.
Ccn2 (zeige CTGF Antikörper) is a regulator of the transition through cytokinesis during terminal erythropoiesis.
Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination.
B-Myb (zeige MYBL2 Antikörper) represses SMC (zeige DYM Antikörper) elastin (zeige ELN Antikörper) gene expression and cyclin A plays a role in the developmental regulation of elastin (zeige ELN Antikörper) gene expression in the aorta
inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation
an essential role for UHRF1 (zeige UHRF1 Antikörper) phosphorylation by cyclin-dependent kinase 2 (zeige CDK2 Antikörper)/cyclin A2 during early vertebrate development
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.
, cyclin A
, cyclin A2
, Cyclin A2 (Cyclin A)