anti-Maus NOXA Antikörper für Enzyme Immunoassay

Recommended NOXA Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) Antikörper
  • TN3
  • PMAIP1
  • zgc:162379
  • APR
  • NOXA
  • Noxa
  • phorbol-12-myristate-13-acetate-induced protein 1
  • PMAIP1
  • pmaip1
  • Pmaip1
Epitop
N-Term
11
5
5
2
2
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
95
79
45
1
Wirt
Kaninchen
44
41
28
17
Klonalität
Polyklonal
Konjugat
Dieser NOXA Antikörper ist unkonjugiert
6
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
123
35
35
25
22
21
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN5555065
$ 375.38
Zzgl. Versandkosten $45.00

General

Antigen Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1) Antikörper
Epitop N-Term
(11), (5), (5), (2), (2), (2), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(95), (79), (45), (1)
Wirt Kaninchen
(44), (41), (28), (17)
Klonalität
Polyklonal
Konjugat Dieser NOXA Antikörper ist unkonjugiert
(6), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(123), (35), (35), (25), (22), (21), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-NOXA Antikörper

Target Details NOXA Anwendungsinformationen Handhabung Bilder
Spezifität This antibody detects NOXA.
Reinigung Peptide affinity chromatography
Immunogen Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.
Isotyp IgG

Target Details NOXA

Produktdetails anti-NOXA Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung NOXA (PMAIP1 Antibody Abstract)
Hintergrund Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified , which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9 . Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53 (1-3). Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development (4).Synonyms: PMA-induced protein 1, PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1
Gen-ID 58801
NCBI Accession NP_067426
UniProt Q9JM54
Pathways p53 Signalweg, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus

Anwendungsinformationen

Produktdetails anti-NOXA Antikörper Target Details NOXA Handhabung Bilder zurück nach oben
Applikationshinweise ELISA. Western blot. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-NOXA Antikörper Target Details NOXA Anwendungsinformationen Bilder zurück nach oben
Konzentration 0.5 mg/mL
Buffer PBS containing 0.02 % sodium azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.