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Viral proteins aim to subvert TRAF3 antiviral action.
Mechanistic studies showed that HACE1 (zeige HACE1 Proteine) exerts its inhibitory role on virus-induced signaling by disrupting the MAVS (zeige MAVS Proteine)-TRAF3 complex.
An important B cell-sp (zeige TNFRSF1A Proteine)ecific role for TNFR-associated factor 3 is the (zeige TNFRSF1A Proteine) inhibition of homeostatic s (zeige TLR4 Proteine)urvival, directly relevant to the common occurrence of TNFR- (zeige TNFRSF1A Proteine)associated factor 3 mutations in human B cell malignancies. Review.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (tumor necrosis factor (zeige TNF Proteine) receptor-associated factor 3) and CYLD (zeige CYLD Proteine) (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 and CYLD (zeige CYLD Proteine) correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors
Data suggest that UBR5 down-regulates levels of TRAF3, a key component of Toll (zeige TLR4 Proteine)-like receptor signaling, via the miRNA pathway; p90RSK (zeige RPS6KA1 Proteine) is an upstream regulator of UBR5; p90RSK (zeige RPS6KA1 Proteine) phosphorylates UBR5 as required for translational repression of TRAF3 mRNA. (UBR5 = ubiquitin protein ligase E3 component n-recognin 5 protein; TRAF3 = TNF receptor-associated factor 3; p90RSK (zeige RPS6KA1 Proteine) = 90 kDa ribosomal protein S6 (zeige RPS6 Proteine) kinase (zeige RPS6KB1 Proteine))
The GA genotype and GA+AA genotype of TRAF3 rs12147254 were found to increase the risk of coronary heart disease among T2DM patients. the GACGAC haplotype in TRAF3 had a protective effect on T2DM micro-macrovascular complications.
These data suggest an interplay between CELF2 (zeige CELF2 Proteine) and hnRNP C as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8.
DDX3 (zeige DDX3X Proteine) directly regulates TRAF3 ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS (zeige MAVS Proteine).
The NleB effector limited host IFN-beta (zeige IFNB1 Proteine) production by inhibiting Lys (zeige LYZ Proteine)(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase (zeige GTDC2 Proteine) activity of NleB.
Depletion of LAP1 during early embryonic myogenesis leads to growth retardation and premature death.
In B lymphocytes, TNFR (zeige TNFRSF1A Proteine)-associated factor 3 inhibits signaling by TNFR (zeige TNFRSF1A Proteine) superfamily receptors, Toll (zeige TLR4 Proteine)-like receptors, and interleukin-6R. In T lymphocytes, TNFR (zeige TNFRSF1A Proteine)-associated factor 3 is required for normal signaling by the T cell antigen receptor, while inhibiting signaling by the interleukin-2 (zeige IL2 Proteine) receptor. Cytoplasmic TNFR (zeige TNFRSF1A Proteine) -associated factor 3 restrains nuclear factor-kappaB2 activation in both T and B cells. Review.
TRAF3 may likely induce apoptosis and resistance to proliferation and may be a new target to inhibit the cyst formation in polycystic kidney disease by regulating the NF-kappaB (zeige NFKB1 Proteine) signaling pathway Bcl-2 (zeige BCL2 Proteine) and Bcl-xl (zeige BCL2L1 Proteine) activity.
this study shows that TRAF3 ubiquitination triggers expulsion of intracellular bacteria by exocyst complex
Data (including data from studies using knockout mice) suggest that RANKL (zeige TNFSF11 Proteine) enhances TNF (zeige TNF Proteine)-induced osteoclast formation from precursor spleen cells and enhances bone resorption independently of Traf6 (zeige TRAF6 Proteine) by degrading Traf3, a known inhibitor of osteoclastogenesis. (RANKL (zeige TNFSF11 Proteine) = osteoclast differentiation factor (zeige TNFSF11 Proteine); TNF (zeige TNF Proteine) = tumor necrosis factor (zeige TNF Proteine); Traf (zeige TRAF1 Proteine) = TNF (zeige TNF Proteine) receptor-associated factor)
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (zeige FOSL1 Proteine) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 Proteine) (TRIF (zeige RNF138 Proteine)), and Tank-binding kinase 1 (TBK1 (zeige TBK1 Proteine)) via impairing K63-linked polyubiquitination of TRAF3 and TRIF (zeige RNF138 Proteine).
These findings reveal a novel mechanism that endotoxin tolerance reprograms mitogen-activated protein kinase (zeige MAPK1 Proteine) signaling by suppressing Pellino 1 (zeige PELI1 Proteine)-mediated K63-linked ubiquitination of cIAP2 (zeige BIRC3 Proteine), K48-linked ubiquitination, and degradation of TRAF3.
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
Hepatocyte TRAF3 promotes liver steatosis and insulin (zeige INS Proteine) resistance through targeting TAK1 (zeige NR2C2 Proteine)-dependent signaling.
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Several alternatively spliced transcript variants encoding three distinct isoforms have been reported.
CD40 associated protein 1
, CD40 binding protein
, CD40 receptor associated factor 1
, LMP1-associated protein 1
, CD40 receptor-associated factor 1
, TNF receptor-associated factor 3