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In cultured macrophages, LPS (zeige TLR4 ELISA Kits)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CPT1B ELISA Kits) was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 ELISA Kits) and IkappaBzeta activities.
Data show that I-kappa-B-zeta (IkappaBzeta) regulates macrophage interleukin-10 (zeige IL10 ELISA Kits) (IL_10) expression by directly activated the Il-10 (zeige IL10 ELISA Kits) promoter.
A possible important role of Nfkbiz in modulating the progression of inflammatory diseases in which IFN-gamma (zeige IFNG ELISA Kits) and IL-1 (zeige IL1A ELISA Kits) are abundant.
Nfkbiz-/- keratinocytes were hypoproliferative. In skin from Nfkbiz-/- mice, the expression of the keratinocyte differentiation markers K10 (zeige KRT10 ELISA Kits) and filaggrin (zeige FLG ELISA Kits) were reduced, although that of K14 (zeige KRT14 ELISA Kits) was unchanged.
These data reveal a previously unappreciated role for IkappaB-zeta in IFN-gamma (zeige IFNG ELISA Kits) production in T cells and the immunoregulatory function of T regulatory cells.
The pyrimidine-rich IkappaBzeta-responsive site plays an essential role in productive interaction of IkappaBzeta with the p50 (zeige LSP1 ELISA Kits)-DNA complex.
IkappaB-zeta regulates TLR-mediated CSR by inducing AID
The IkappaB-zeta-Akirin2 (zeige AKIRIN2 ELISA Kits)-BAF60 complex physically links the NF-kappaB (zeige NFKB1 ELISA Kits) and SWI (zeige SMARCA1 ELISA Kits)/SNF (zeige SNRPA ELISA Kits) complexes in innate immune cell activation.
The IkappaB-zeta-deficient B cells exhibited impaired proliferation and enhanced up-regulation of CD86 (zeige CD86 ELISA Kits) following stimulation of TLR9 (zeige TLR9 ELISA Kits), but not the BCR (zeige BCR ELISA Kits), indicating critical roles for IkappaB-zeta in TLR signaling in B cells.
IkappaBzeta-deficient mice showed significantly impaired CCL2 (zeige CCL2 ELISA Kits) secretion.
In cultured macrophages, LPS (zeige IRF6 ELISA Kits)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CCL2 ELISA Kits) was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 ELISA Kits) and IkappaBzeta activities.
IkappaB-zeta regulates human monocyte pro-inflammatory responses induced by Streptococcus pneumoniae.
TNF-alpha (zeige TNF ELISA Kits)- and IL-17A (zeige IL17A ELISA Kits) mediate synergistic induction of DEFB4 gene expression in human keratinocytes through IkappaBzeta
We propose a previously unappreciated role of IkappaBzeta in the inflammatory micromilieu as well as progression in glioma
These results indicate that the LPS (zeige IRF6 ELISA Kits)/IL-1beta (zeige IL1B ELISA Kits)-MyD88 (zeige MYD88 ELISA Kits) axis plays a crucial role for stabilization of IkappaB-zeta mRNA.
Interferon-gamma (IFN-gamma (zeige IFNG ELISA Kits)) interferes with the IL-1 (zeige IL1A ELISA Kits)/IKB-zeta axis in beta-glucan-activated dendritic cells and promotes T cell-mediated immune responses with increased release of IFN-gamma (zeige IFNG ELISA Kits) and IL-22 (zeige IL22 ELISA Kits).
NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b (zeige IL1B ELISA Kits)-induced IL-6 (zeige IL6 ELISA Kits) and GMCSF (zeige CSF2 ELISA Kits).
IkappaBzeta functions as an important regulator of IFN-gamma (zeige IFNG ELISA Kits) in human NK cells
NF-kappaB (zeige NFKB1 ELISA Kits)-binding cofactor inhibitor of NF-kappaB (zeige NFKB1 ELISA Kits)-zeta (IkappaB-zeta) is constitutively expressed in HTLV-I-infected T cell lines and ATL cells, and Tax (zeige CNTN2 ELISA Kits) transactivates the IkappaB-zeta gene, mainly through NF-kappaB (zeige NFKB1 ELISA Kits).
our data demonstrate that IkappaB-zeta is essential for nuclear NF-kappaB (zeige NFKB1 ELISA Kits) activity in activated B-cell-like subtype of diffuse large B-cell lymphoma
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.
, NF-kappa-B inhibitor zeta
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
, molecule associated with ankyrin repeats induced by lipopolysaccharide
, NF-kappa-B inhibitor zeta-like
, IL-1 inducible nuclear ankyrin-repeat protein
, molecule possessing ankyrin repeats induced by lipopolysaccharide
, molecule possessing ankyrin-repeats induced by lipopolysaccharide
, Ikappa B-zeta variant 3
, molecule possessing ankyrin repeats induced by lipopolysaccharide (MAIL), homolog of mouse