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Combined computational and biochemical studies indicated that the extent of NF-kappaB (zeige NFKB1 ELISA Kits)-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB (zeige NFKB1 ELISA Kits) activation in macrophages compared to that in fibroblasts
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB (zeige NFKB1 ELISA Kits)(p65 (zeige NFkBP65 ELISA Kits)), miR (zeige MLXIP ELISA Kits)-196b-3p, Meis2 (zeige MEIS2 ELISA Kits), and PPP3CC (zeige PPP3CC ELISA Kits) is formed during the emergence of castration-resistant prostate cancer.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
SM22alpha (zeige TAGLN ELISA Kits) is a phosphorylation-regulated (zeige PHAX ELISA Kits) suppressor of IKK (zeige CHUK ELISA Kits)-IkappaBalpha-NF-kappaB (zeige NFKB1 ELISA Kits) signaling cascades.
We found potential links between the alterations in expression of Tsc22d3 (zeige TSC22D3 ELISA Kits), Nfkbia and Pdyn (zeige PDYN ELISA Kits), and different aspects of susceptibility to stress.
Specific and constitutive deletion of the inhibitor of NF-kappaB (zeige NFKB1 ELISA Kits) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection
GRK6 (zeige GRK6 ELISA Kits) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (zeige GRK6 ELISA Kits) suppresses TNF-alpha (zeige TNF ELISA Kits)-induced NF-kappaappaB signaling.
Results demonstrate novel roles of TNFRII (zeige TNFRSF1B ELISA Kits) in the regulation of Abeta (zeige APP ELISA Kits) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (zeige TNFRSF1B ELISA Kits) levels and elevating phosphorylated IkappaBalpha by SUMOylation.
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.
Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (zeige NFKB1 ELISA Kits) inhibitor beta (IkappaBbeta (zeige NFKBIB ELISA Kits)), cleaving them in a mouse hemorrhage model.
FBXO32 (zeige FBXO32 ELISA Kits) activates NF-kappaB (zeige NFKB1 ELISA Kits) through IkappaBalpha degradation in inflammatory and genotoxic stress
The results showed that NFKB1 (zeige NFKB1 ELISA Kits) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB (zeige NFKB1 ELISA Kits) have been described.
Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (zeige NFKB1 ELISA Kits) (RelA (zeige NFkBP65 ELISA Kits)-p50 (zeige CD40 ELISA Kits)) heterodimer induced by DNA or IkappaBalpha binding.
Sam68 (zeige KHDRBS1 ELISA Kits) is essential for DNA damage-induced NF-kappaB (zeige NFKB1 ELISA Kits) activation and colon tumorigenesis.
Specifically, BCA2 serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB (zeige NFKB1 ELISA Kits) components in the cytoplasm. Since HIV-1 utilizes NF-kappaB (zeige NFKB1 ELISA Kits) to promote proviral transcription, the BCA2-mediated inhibition of NF-kappaB (zeige NFKB1 ELISA Kits) significantly decreases the transcriptional activity of HIV-1.
This study found that NFKBIA mRNAs was significantly expressed in normal tissues compared with glioma specimens.
Findings indicate the prognostic value of NFKB inhibitor alpha (NFKBIA) in lower-grade gliomas (LGGs).
W346 effectively inhibited tumor necrosis factor (TNF-a (zeige TNF ELISA Kits))-induced NF-kappaB (zeige NFKB1 ELISA Kits) activation by suppressing IKK (zeige CHUK ELISA Kits) phosphorylation, inhibiting IkB (zeige NFKBIB ELISA Kits)-a degradation, and restraining the accumulation of NF-kappaB (zeige NFKB1 ELISA Kits) subunit p65 (zeige GORASP1 ELISA Kits) nuclear translocation. W346 also affected NF-kappaB (zeige NFKB1 ELISA Kits)-regulated downstream products involved in cycle arrest and apoptosis.
treating cells with SZC014 resulted in a decrease in phosphorylation of IkBa and NF-kappaB (zeige NFKB1 ELISA Kits)/p65 (zeige GORASP1 ELISA Kits) and NF-kappaB (zeige NFKB1 ELISA Kits)/p65 (zeige GORASP1 ELISA Kits) nuclear translocation. The cytotoxic activities of seven OA derivatives were generally stronger than that of OA, among which, SZC014 possessed the most potent anticancer activity in SGC7901 cells and would be a promising chemotherapic agent for the treatment of gastric cancer
IkappaB-alpha protein was stabilized by COMMD1 (zeige COMMD1 ELISA Kits), which attenuated NF-kappaB (zeige NFKB1 ELISA Kits) signaling during Toll (zeige TLR4 ELISA Kits)-like receptor ligand and tumor necrosis factor alpha (zeige TNF ELISA Kits) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
NFKBIA has a role as a marker of NF-kappaB (zeige NFKB1 ELISA Kits)/p65 (zeige SYT1 ELISA Kits) activation in the early embryo.
NF-kappaB (zeige NFKB1 ELISA Kits) has a role in increasing PDGF-B (zeige PDGFB ELISA Kits) transcription
AIP1 (zeige PDCD6IP ELISA Kits) is a novel transducer in TNF (zeige TNF ELISA Kits)-induced TRAF2 (zeige TRAF2 ELISA Kits)-dependent activation of ASK1 (zeige MAP3K5 ELISA Kits) that mediates a balance between JNK (zeige MAPK8 ELISA Kits) versus NF-kappaB (zeige NFKB1 ELISA Kits) signaling
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
NF-kappa-B inhibitor alpha
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light polyp gene enhancer in B-cell 1
, major histocompatibility complex enhancer-binding protein MAD3
, nuclear factor of kappa light chain gene enhancer in B-cells
, I kappa B-alpha
, NF-kappaB inhibitor alpha
, REL-associated protein pp40
, Rel-associated pp40
, IkappaB alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha