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Human Monoclonal GABPA Primary Antibody für ICC, ELISA - ABIN969163
Batchelor, Piper, de la Brousse, McKnight, Wolberger: The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA. in Science (New York, N.Y.) 1998
Show all 3 Pubmed References
Human Polyclonal GABPA Primary Antibody für IF (p), IHC (p) - ABIN1714176
Chang, Wu, Xu, Liao, Wu, Cheng: Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation. in Molecules (Basel, Switzerland) 2015
Human Polyclonal GABPA Primary Antibody für ICC, IF - ABIN4313121
Sharma, Massie, Butter, Mann, Bon, Ramos-Montoya, Menon, Stark, Lamb, Scott, Warren, Neal, Mills: The ETS family member GABP? modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer. in Nucleic acids research 2014
Collectively, our data indicate that GABPA inhibits hepatocellular carcinoma cell migration and could serve as a novel biomarker for prognosis
CRISPR-mediated reversal of mutant TERT (zeige TERT Antikörper) promoters, or deletion of its long-range interacting chromatin, abrogates GABPA binding and long-range interactions, leading to depletion of active histone marks, loss of POL2 recruitment, and suppression of TERT (zeige TERT Antikörper) transcription
potential mechanism of TERT (zeige TERT Antikörper) reactivation mediated by a novel long-range chromatin interaction between the TERT (zeige TERT Antikörper) promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT (zeige TERT Antikörper) promoters but not in wild-type promoters.
a key role for GABPA/B1 as the critical ETS (zeige ETS1 Antikörper) transcription factors deregulating SDHD (zeige SDHD Antikörper) expression in the context of highly recurrent promoter mutations in melanoma.
Analyses of data sets link GABPa to cognitive disorders, diabetes, KRAB zinc finger (KRAB-ZNF (zeige ZNF629 Antikörper)), and human-specific genes.
ELF1 (zeige EFNA2 Antikörper) binding occurs at both TERT (zeige TERT Antikörper) promoter mutations in melanoma in vitro such that increased recruitment of GABP is enabled by the spatial architecture of native and novel ETS (zeige ETS1 Antikörper) motifs in the TERT (zeige TERT Antikörper) promoter region.
The results suggest that NRF-2alpha is a regulator of SIRT3 (zeige SIRT3 Antikörper) expression and may shed light on how SIRT3 (zeige SIRT3 Antikörper) is upregulated during nutrient stress.
GABPalpha Binding to Overlapping ETS (zeige ETS1 Antikörper) and CRE DNA Motifs Is Enhanced by CREB1 (zeige CREB1 Antikörper)
Expression of the ETS transcription factor (zeige FEV Antikörper) GABPalpha is positively correlated to the BCR (zeige BCR Antikörper)-ABL1/ABL1 (zeige ABL1 Antikörper) ratio in CML (zeige BCR Antikörper) patients and affects imatinib sensitivity in vitro.
study supports the crucial role of GABP in myeloid cell differentiation and identified ITGAM/CD11b (zeige ITGAM Antikörper) as a novel GABP target gene
conditionally deleted Gabpa, the DNA-binding component of this transcription factor complex, from embryonic fibroblasts to examine the role of Gabp in mitochondrial biogenesis, function, and gene expression
Loss of Gabpalpha prevented development of CML, although mice continued to generate BCR-ABL (zeige ABL1 Antikörper)-expressing Gabpalpha-null cells for months that were serially transplantable and contributed to all lineages in secondary recipients.
NRF-2 (zeige NFE2L2 Antikörper) and NRF-1 (zeige NRF1 Antikörper) operate in a concurrent and parallel manner in mediating the tight coupling between energy metabolism and neuronal activity at the molecular level.
Through genome-wide mapping of GABPalpha binding and transcriptomic analysis of GABPalpha-deficient HSCs, we identified Zfx (zeige ZFX Antikörper) and Etv6 (zeige ETV6 Antikörper) transcription factors and prosurvival Bcl-2 (zeige BCL2 Antikörper) family members including Bcl-2 (zeige BCL2 Antikörper), Bcl-X(L (zeige BCL2L1 Antikörper)), and Mcl-1 (zeige MCL1 Antikörper) as direct GABP target genes.
Disruption of Gabpa was associated with a marked reduction in myeloid progenitor cells, and Gabpalpha null myeloid cells express reduced levels of the transcriptional repressor, Gfi-1.
chemical shift and secondary structure of the PNT (zeige ETS2 Antikörper)/SAM (zeige TTN Antikörper) domains
Erralpha (zeige ESRRA Antikörper) and GA-binding protein a (zeige GPR153 Antikörper) partner with PGC-1alpha (zeige PPARGC1A Antikörper) in muscle to form a double-positive-feedback loop that drives the expression of many oxidative phosphorylation genes
Gabpa function is essential and is not compensated for by other ETS (zeige ETS1 Antikörper) transcription factors and is consistent with a specific requirement for Gabp expression for the maintenance of target genes involved in embryo essential mitochondrial cellular functions
GABP is essential for the regulation of IL-7Ralpha (zeige IL7R Antikörper) expression in T cells.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene.
GA binding protein transcription factor, alpha subunit 60kDa
, transcription factor GABP alpha subunit
, GA binding protein transcription factor, alpha subunit (60kD)
, GA-binding protein alpha chain-like
, GA repeat binding protein, alpha
, GA-binding protein alpha chain
, nuclear respiratory factor 2 alpha
, GA binding protein transcription factor alpha subunit 60kDa
, GABP subunit alpha
, human nuclear respiratory factor-2 subunit alpha
, nuclear respiratory factor 2 alpha subunit
, nuclear respiratory factor 2 subunit alpha
, transcription factor E4TF1-60
, GA repeat binding protein alpha
, GA-binding protein alpha-subunit
, E4tf1-60 transcription factor