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Its mutations were seen in patients with ALS and frontotemporal dementia.
TUBA4A mutations are not associated with FTD (zeige FTL ELISA Kits).
In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required.
This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis.
Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin (zeige TUBB ELISA Kits) cytoskeleton mediated by binding Tau protein.
TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability
TUBA4A is significantly increased in spermatazoa from men with azoospermia.
The results suggested that cytoskeletal alterations in the amygdala determined by tubulin (zeige TUBB ELISA Kits) seem to be involved in the pathophysiology of drug addiction
Subunits of alphaB crystallin (zeige CRYAB ELISA Kits) that exchange dynamically with the alphaB crystallin (zeige CRYAB ELISA Kits) complex can interact with tubulin (zeige TUBB ELISA Kits) subunits to regulate the equilibrium between tubulin (zeige TUBB ELISA Kits) and microtubules.
Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 (zeige CAV1 ELISA Kits) was dissociated from a complex with flotillin-1 (zeige FLOT1 ELISA Kits) and alpha-tubulin.
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.
, tubulin alpha chain
, tubulin, alpha 1 (testis specific)
, alpha 4 tubulin
, tubulin alpha-4 chain
, tubulin, alpha 8
, tubulin H2-alpha
, tubulin alpha-1 chain
, tubulin alpha-4A chain
, alpha-tubulin 4
, alpha-tubulin isotype M-alpha-4
, tubulin, alpha 4
, alpha-tubulin 1
, tubulin, alpha 1
, tubulin alpha 4a
, tubulin, alpha 4a