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anti-Human CYP17A1 Antikörper:
anti-Mouse (Murine) CYP17A1 Antikörper:
anti-Rat (Rattus) CYP17A1 Antikörper:
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Human Polyclonal CYP17A1 Primary Antibody für IHC (p), IHC - ABIN251324
Efstathiou, Titus, Tsavachidou, Tzelepi, Wen, Hoang, Molina, Chieffo, Smith, Karlou, Troncoso, Logothetis: Effects of abiraterone acetate on androgen signaling in castrate-resistant prostate cancer in bone. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012
Show all 3 Pubmed References
Human Polyclonal CYP17A1 Primary Antibody für IF (p), IHC (p) - ABIN720071
Wilsher, Stansfield, Greenwood, Trethowan, Anderson, Wooding, Allen: Ovarian and placental morphology and endocrine functions in the pregnant giraffe (Giraffa camelopardalis). in Reproduction (Cambridge, England) 2013
Human Monoclonal CYP17A1 Primary Antibody für FACS, IHC - ABIN4302053
Spade, Hall, Saffarini, Huse, McDonnell, Boekelheide: Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay. in Toxicological sciences : an official journal of the Society of Toxicology 2014
Data show that cytochrome P450 (zeige CYP Antikörper) enzymes Cyp17-I, Cyp11c1 (zeige CYP11B2 Antikörper), Cyp19a1a and Cyp19a1b and one of their regulators forkhead protein (zeige FOXO4 Antikörper) Foxl2a were detected both in the testis and ovary.
In vivo, clotrimazole induced a concentration-dependent increase of cyp17a1 gene expression and Cyp17-I protein synthesis in zebrafish testis.
Effects of sexual steroids on the expression of foxl2 (zeige FOXL2 Antikörper) in Gobiocypris rarus
the enzyme P450c17 seemed to be expressed in ovary and non-gonadal tissues including the brain, gill, liver and intestine
The immunolocalization of P450c17, detected in the ovaries of pregnant pigs and fetal porcine gonads, indicates the potential sites of androgen synthesis.
LH and insulin (zeige INS Antikörper) stimulate transcription of -976/+31 bp 5 (zeige HSPD1 Antikörper)'-upstream cis (zeige CISH Antikörper)-acting region of porcine CYP17 gene. Maximal transcriptional responsiveness requires proximal Sp1 (zeige SP1 Antikörper) and AP-2-like (zeige TFAP2D Antikörper) sequences -193 to -180 bp 5 (zeige HSPD1 Antikörper)' upstream of transcriptional start site.
Synthesis of androstenone in pig testis is not directly affected by any polymorphisms in the coding region of the porcine CYP17 gene.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone
These results demonstrate the differential effects of two forms of CYB5 (zeige CYB5A Antikörper) on the three activities of porcine CYP17A1 and show that CYB5B (zeige CYB5B Antikörper) does not stimulate the andien-beta synthase activity of CYP17A1.
through mouse-to-human search and validation, we found that CYP17A1 is overexpressed in hepatocellular carcinomas and it has great potentiality as a noninvasive marker for hepatocellular carcinoma detection
A homodimer model can resolve the conundrum as to how cytochrome P450 (zeige CYP Antikörper) oxidoreductase (zeige TXNRD1 Antikörper) and cytochrome b5 (zeige CYB5A Antikörper) compete for the same binding site on cytochrome P450c17. (Review)
Nominally significant parental genetic effects were found between the SNPs rs11191548 (CYP17A1) (paternal, beta = 2.78+/-1.49, P = 6.1x10-2 for SBP (zeige SHBG Antikörper) and beta = 3.60+/-1.24, P = 3.7x10-3 for DBP (zeige GC Antikörper)), rs17367504 (MTHFR (zeige MTHFR Antikörper)) (paternal, beta = 2.42+/-0.93, P = 9.3x10-3 for SBP (zeige SHBG Antikörper) and beta = 1.89+/-0.80, P = 1.8x10-2 for DBP (zeige GC Antikörper) and maternal, beta = -1.32+/-0.60, P = 2.9x10-2 and beta = -1.97+/-0.77, P = 1.0x10-2, for SBP (zeige SHBG Antikörper) and DBP (zeige GC Antikörper) respecti...
Wild-type CYP17 allele when combined with LOH/MSI (zeige MSI1 Antikörper) in steroid metabolism genes may play a role in ER and/or PR negative breast cancers.
Data suggest CYP17A1, with electron donor NADPH-P450 reductase (zeige POR Antikörper), is inherently distributive enzyme but that some processivity is present; some 17alpha-hydroxy pregnenolone formed does not dissociate from CYP17A1 before conversion to dehydroepiandrosterone; CYP5A does not enhance reaction by decreasing k(off) of ligands of CYP17A1. (CYP17A1 = cytochrome P450 (zeige CYP Antikörper), family 17, subfamily A (zeige CYP Antikörper), polypeptide 1 (zeige CYP Antikörper); CYP5A = cytochrome b5 (zeige CYB5A Antikörper))
we identified a novel (K144del) and a widely reported (Y329 fs) heterozygous mutations of CYP17A1 gene from a 17OHD patient. Haplotyping analysis showed the common mutation Y329 fs in China came from the same ancestor, which explains the reason that 17OHD was the second cause of congenital adrenal hyperplasia in China.
Thus, although Mn-b5 binds to CYP17A1, it is unable to enhance the lyase reaction, strongly suggesting that cyt b5 has a redox effector role in enhancement of the CYP17A1 mediated lyase reaction necessary for androgen synthesis.
The activities of P450 (zeige CYP2B6 Antikörper) 17A1 are regulated by cyt b5 that enhances the 17,20-lyase reaction by promoting the coupling of P450 (zeige CYP2B6 Antikörper) 17A1 and cytochrome P450 reductase (CPR (zeige POR Antikörper)), allosterically. Cyt b5 can also act as an electron donor to enhance the 16-ene-synthase activity of human P450 (zeige CYP2B6 Antikörper) 17A1.
The results showed that CYP17A1 gene was not conclusively linked to either Insulin (zeige INS Antikörper) resistance (IR) or its associated increased androgen secretion in non-obese women with polycystic ovarian syndrome (PCOS). We propose that an increased sensitivity of insulin (zeige INS Antikörper) on the ovarian cells may be the predominant reason for the clinical effects and symptoms of androgen excess observed in non-obese PCOS patients in our region.
CYP17A1 defects were associated with amenorrhea, ovarian macrocysts and the diagnosis of 46, XX syndrome.
BMP6 (zeige BMP6 Antikörper) has a role in downregulating INSL3 (zeige INSL3 Antikörper) and CYP17A1 and other proteins that modulate ovarian androgen production
The binding of SF-1 (zeige NR5A1 Antikörper) to the CYP17 and StAR promoter regions increased in theca cells incubated with low levels of luteinizing hormone.
Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW]
the bovine genome contains three paralogous copies of the CYP17A1 gene, of which two (CYP17A1b and CYP17A1x) might be silenced by epigenetic modification (promoter methylation).
Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (zeige CYP19A1 Antikörper), HSD3B1 (zeige HSD3B1 Antikörper), and CYP17A1 transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.
effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone [P450c17]
Serum free culture conditions significantly enhanced Cyp17 and Csh1 but not Hsd3b (zeige HSD3B1 Antikörper) expression in trophoblast.
Demonstration of the physiologic importance of cytochrome b5 (zeige CYB5A Antikörper) activating the 17,20-lyase reaction and the production of 19-carbon sex steroids from 21-carbon precursors in mice.
TRalpha (zeige GNAT1 Antikörper)/T3 directly acts on the P450c17 promoter, which contains putative thyroid response elements, and indirectly acts on the promoter of steroidogenic enzyme genes by modulating Nur77 (zeige NR4A1 Antikörper) transactivation on these promoters.
ata indicate that androgen receptor (AR (zeige AR Antikörper)) regulation on Klk27 (zeige KLK1B27 Antikörper), Rhox5, Eppin, and Cyp17 genes in adult mouse testis using chromatin immunoprecipitation (ChIP) assays.
Data suggest that newly synthesized protein(s) are required for cAMP induction of CYP17 and 3-beta-HSD (zeige HSD3B1 Antikörper) mRNA levels (but not of CYP11A (zeige CYP11A1 Antikörper) mRNA levels). [REVIEW]
Data suggest that immune-activation of testicular interstitial macrophages may cause inhibition of P450c17 gene expression in Leydig cells.
Mamld1 (zeige MAMLD1 Antikörper) enhances Cyp17a1 expression primarily in Leydig cells and permit to produce a sufficient amount of testosterone for male sex development, independently of the Hes3 (zeige HES3 Antikörper)-related non-canonical Notch (zeige NOTCH1 Antikörper) signaling
Fxr (zeige NR1H4 Antikörper)-/-Shp (zeige LAMC1 Antikörper)-/- mice exhibited cholestasis and liver injury as early as 3 weeks of age with strong induction of cytochrome P450 (zeige CYP Antikörper), family 17, subfamily a (zeige CYP Antikörper), polypeptide 1 (zeige CYP Antikörper) (Cyp17a1)
Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc (zeige CYP11A1 Antikörper), P450 (zeige POR Antikörper)(17alpha) and 17beta-HSD (zeige HSD17B1 Antikörper) in mice.
cAMP induces expression of Cyp17 by a PKA-mediated mechanism which is inhibited by MIS (zeige AMH Antikörper) signal transduction
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
cytochrome P450 17A1
, steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450c17
, cytochrome P450-C17
, cytochrome P450 XVIIA1
, steroid 17-alpha-monooxygenase
, steroidogenic cytochrome P450 17-hydroxylase/lyase
, Cytochrome P450 17A1
, Steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450 steroid 17-alpha-hydroxylase/17,20 lyase
, cytochrome P450, family 17, subfamily A, polypeptide 1
, 17-alpha-hydroxyprogesterone aldolase
, 17-alpha-hydroxylase cytochrome P450
, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia
, cytochrome p450 XVIIA1
, cytochrome P450 steroid 17alpha-hydroxylase/17,20 lyase
, cytochrome P450, subfamily XVII
, steroid 17-alpha-hydroxylase
, cytochrome P450, 17
, cytochrome P450, 17a1
, steroid 17-alpha hydroxylase
, Cytochrome P450, subfamily XVII
, cytochrome P450, subfamily 17
, cytochrome P450 17 alpha-hydroxylase