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Apoptosis signal-regulating kinase 1 (ASK1) expression was dramatically suppressed and correlated with hepatocyte nuclear factor 4alpha (HNF4alpha (zeige HNF4A Proteine)) levels in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) tissues.
ASK1 phosphorylated and stabilized TLX (zeige CD46 Proteine), which led induction of HIF-1alpha (zeige HIF1A Proteine), and its downstream VEGF-A (zeige VEGFA Proteine) in an Akt (zeige AKT1 Proteine) dependent manner.
CD40 (zeige CD40 Proteine) activation resulted in down-regulation of Thioredoxin (Trx)-1 (zeige TXN Proteine) to permit ASK1 activation and apoptosis. Although soluble receptor (zeige IFNAR1 Proteine) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (zeige CD40 Proteine) agonist and pharmacological inhibition of Trx-1 (zeige MLL Proteine) was functionally equivalent to the signal triggered by mCD40L
These results suggest that the platelet Ask1 plays an important role in regulation of hemostasis and thrombosis.
from the two catalytic cysteines of TRX1 (zeige MLL Proteine) the residue C32 is responsible for the high-affinity binding of TRX1 (zeige MLL Proteine) to the ASK1-TRX (zeige VAC14 Proteine)-binding domain in reducing conditions
Shotgun mass spectrometry and manual validation identified 12 distinct ASK1 phosphosites. Targeted parallel reaction monitoring assays were used to track the phosphorylation dynamics of each confirmed site in response to treatment.
phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (zeige YWHAZ Proteine) interacts with the kinase domain of ASK1 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.
ASK1 MAP kinase (zeige MAPK1 Proteine) signaling cascade is an important regulator of chondrocyte terminal differentiation.
Pretreatment by IRE1 (zeige ERN1 Proteine) agonist tunicamycin or JNK (zeige MAPK8 Proteine) agonist anisomycin attenuated the effect of psoralen on osteoporotic osteoblasts. Psoralen inhibited apoptosis of osteoporotic osteoblasts by regulating IRE1 (zeige ERN1 Proteine)-ASK1-JNK (zeige MAPK8 Proteine) pathway
Our results thus suggest that GSK-3beta is a key factor involved in ASK1 activation and reactive oxygen species-induced cell death.
PBL27 interacts with both CERK1 and the MAPK (zeige MAPK1 Proteine) kinase kinase MAPKKK5 at the plasma membrane and knockout of MAPKKK5 compromise chitin-induced MAPK (zeige MAPK1 Proteine) kinase activation and disease resistance to Alternaria brassicicola.
The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
These results demonstrate that trans-fatty acids promote extracellular ATP-induced apoptosis by targeting ASK1 and indicate novel TFA (zeige F3 Proteine)-associated pathways leading to inflammatory signal transduction and cell death that underlie the pathogenesis and progression of trans-fatty acids-induced atherosclerosis.
Conversely, treatment with LY294002 (a selective inhibitor of Akt1 (zeige AKT1 Proteine)) reversed the effects of quercetin. In conclusion, these findings highlight the important role of quercetin in protecting against cognitive deficits and inhibiting neuronal apoptosis via the Akt (zeige AKT1 Proteine) signaling pathway. We believe that quercetin might prove to be a useful therapeutic component in treating cerebral I/R diseases in the near future.
ASK1 mediates astrocyte activation and leads to glial scar formation after cerebral ischaemia.
ASK1 mediates 3-NP toxicity and regulates C1q level through the astrocyte TGF-beta (zeige TGFB1 Proteine).
ASK1 signalling regulates brown and beige adipocyte function.
blocking MPTP (zeige PTPN2 Proteine)-mediated TNF (zeige TNF Proteine) signaling through intrathecal administration of TNF (zeige TNF Proteine)-neutralizing antibody prevented Trx1 (zeige TXN Proteine) oxidation and downstream ASK1-p38 MAPK (zeige MAPK14 Proteine) activation
PP2A (zeige PPP2R2B Proteine) and AIP1 (zeige PDCD6IP Proteine) cooperatively induce activation of ASK1-JNK (zeige MAPK8 Proteine) signaling and vascular endothelial cell apoptosis.
These results indicate an important regulatory role of ASK1 in porcine circovirus type 2-induced apoptotic responses.
MAP3K5 is expressed in the heart, liver, spleen, lung, kidney, muscle, fat, pancrea, ileum, and stomach tissues of pigs.
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells\; MAPKKK5 does not activate MAPK/ERK.
, MAP/ERK kinase kinase 5
, MAPK/ERK kinase kinase 5
, MEK kinase 5
, MEKK 5
, apoptosis signal regulating kinase 1
, apoptosis signal-regulating kinase 1
, mitogen activated protein kinase kinase kinase 5
, mitogen-activated protein kinase kinase kinase 5
, mitogen-activated protein kinase kinase kinase 5 pseudogene