MAP2K3 Proteine (MAP2K3)

Bezeichnung:
Mitogen-Activated Protein Kinase Kinase 3 Proteine (MAP2K3)
Auf www.antikoerper-online.de finden Sie aktuell 15 Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Proteine von 8 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP2K3 Antikörper (312) und MAP2K3 Kits (12) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 357 MAP2K3 Produkte verfügbar.
Synonyme:
AW212142, map2k3, MAPKK3, MEK3, MKK3, mMKK3b, Prkmk3, SAPKK-2, SAPKK2, zMKK3
alle Proteine anzeigen Gen GeneID UniProt
Ratte MAP2K3 MAP2K3 303200  
MAP2K3 5606 P46734
MAP2K3 26397 O09110

Weitere Synonyme anzeigen

MAP2K3 Proteine (MAP2K3) nach Spezies

Wählen Sie die gewünschte Spezies

Am meisten referenzierte MAP2K3 Proteine

  1. Human MAP2K3 Protein expressed in Escherichia coli (E. coli) - ABIN667410 : Barr, Marjoram, Xu, Snyderman: Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3. in Biochemical and biophysical research communications 2002 (PubMed)
    Zeige alle 2 Referenzen für 667410

Weitere Proteine zu MAP2K3 Interaktionspartnern

Human Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Interaktionspartner

  1. The results revealed upregulation of MEK3, as well as phosphorylated MEK3 and phosphorylated p38 MAPK (zeige MAPK14 Proteine), in CMM patients. These results provide a "fingerprint" for mechanistic studies of CMM in the future and highlight the importance of MEK3-p38 MAPK (zeige MAPK14 Proteine) activation in CMM.

  2. miR (zeige MLXIP Proteine)-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine), in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.

  3. MKK3 overexpression upregulated the cyclin-dependent kinase (zeige CDK1 Proteine) inhibitors, p16 INK4A and p15 INK4B (zeige CDKN2B Proteine) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression.

  4. Our results suggest that asthma is associated with MKK3 over-expression in CD8 (zeige CD8A Proteine)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia

  5. MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3.

  6. study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls

  7. study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation

  8. miR-20a acts in a feedback loop to repress the expression of MKK3 and to negatively regulate the p38 pathway-mediated VEGF-induced endothelial cell migration and angiogenesis

  9. Data suggest aberrant MAP2K protein (MKK3, MKK4 (zeige MAP2K4 Proteine), MKK6 (zeige MAP2K6 Proteine), and MKK7 (zeige MAP2K7 Proteine)) expression indicates that altered cellular signal transduction mediated via JNK (zeige MAPK8 Proteine) and p38 (zeige CRK Proteine) may be common in bladder cancer.

  10. the balance between MKK6 (zeige MAP2K6 Proteine) and MKK3 mediates p38 MAPK (zeige MAPK14 Proteine) associated resistance to cisplatin in NSCLC

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) Interaktionspartner

  1. ATF3 (zeige ATF3 Proteine) upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38 (zeige CRK Proteine)-transforming growth factor-beta signaling.

  2. miR (zeige MLXIP Proteine)-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine), in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.

  3. miR (zeige MLXIP Proteine)-21a-5p inhibited BPA (zeige DST Proteine) induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK (zeige MAPK14 Proteine) in 3T3-L1 cells

  4. this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.

  5. Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 (zeige AKT1 Proteine) pathway.

  6. Our results suggest that asthma is associated with MKK3 over-expression in CD8 (zeige CD8A Proteine)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia

  7. MKK3 and MKK6 (zeige MAP2K6 Proteine) differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 (zeige MAP2K6 Proteine) likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.

  8. results designate MKK3 as a novel, positive regulator of SCF (zeige KITLG Proteine)-induced mast cell proliferation and a critical signaling protein for AP-1 (zeige JUN Proteine)-dependent IL-6 (zeige IL6 Proteine) production

  9. findings demonstrate a critical role for mitochondria in the pathogenesis of sepsis that involves a previously unrecognized function of MKK3 in mitochondrial quality control

  10. Endothelial MKK3 is neede for inflammatory cell recruitment to the lungs, mitochondrial oxidant-mediated AP-1 (zeige JUN Proteine), NF-kappaB (zeige NFKB1 Proteine) activation, & ICAM-1 (zeige ICAM1 Proteine) expression during LPS (zeige TLR4 Proteine) challenge.

MAP2K3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Alternative names and synonyms associated with MAP2K3

  • MAP kinase activator XMEK3 (map2k3)
  • mitogen activated protein kinase kinase 3 (Map2k3)
  • mitogen-activated protein kinase kinase 3 (MAP2K3)
  • mitogen-activated protein kinase kinase 3 (Map2k3)
  • mitogen-activated protein kinase kinase 6 (map2k6)
  • AW212142 Protein
  • map2k3 Protein
  • MAPKK3 Protein
  • MEK3 Protein
  • MKK3 Protein
  • mMKK3b Protein
  • Prkmk3 Protein
  • SAPKK-2 Protein
  • SAPKK2 Protein
  • zMKK3 Protein

Bezeichner auf Proteinebene für MAP2K3

MAP kinase kinase 3 , MAPK/ERK kinase 3 , MAPKK 3 , MEK 3 , SAPK kinase 2 , dual specificity mitogen-activated protein kinase kinase 3 , stress-activated protein kinase kinase 2 , mitogen activated protein kinase kinase 3 , protein kinase, mitogen-activated, kinase 3 , MAP kinase kinase 6 , MAPKK 6 , dual specificity mitogen-activated protein kinase kinase 6 , mitogen-activated protein kinase kinase 3

GENE ID SPEZIES
399150 Xenopus laevis
303200 Rattus norvegicus
5606 Homo sapiens
489547 Canis lupus familiaris
26397 Mus musculus
516039 Bos taurus
416496 Gallus gallus
65239 Danio rerio
Ausgewählte Anbieter für MAP2K3 Proteine (MAP2K3)
Haben Sie etwas anderes gesucht?