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Results show that ATF2 is highly expressed in renal cell carcinoma (zeige MOK Proteine) (RCC (zeige XRCC1 Proteine)) tissues and promotes RCC (zeige XRCC1 Proteine) cell proliferation, migration and invasion. The study suggests that ATF2 exerts an oncogenic role in RCC (zeige XRCC1 Proteine).
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
this study demonstrates that CPEB2 (zeige CPEB2 Proteine) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
Noxin facilitated the expression of Cyclin D1 (zeige CCND1 Proteine) and Cyclin E1 (zeige CCNE1 Proteine) through activating P38 (zeige CRK Proteine)-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer
these observations suggest that CD99 (zeige CD99 Proteine) is involved in the regulation of CD1a (zeige CD1A Proteine) transcription and expression by increasing ATF-2.
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2. [review]
TNF (zeige TNF Proteine) induces the binding of ATF2 to the TNF (zeige TNF Proteine)-responsive element.
miR (zeige MLXIP Proteine)-204 may act as a tumor suppressor by directly targeting ATF2 in non-small cell lung cancer
the variant alleles of TSG101 (zeige TSG101 Proteine) rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 (kg/m(2)) and postmenopausal women, respectively
Results reveal that mitochondrial ATF2 is associated with the induction of apoptosis and BRAF (zeige BRAF Proteine) inhibitor resistance through Bim (zeige BCL2L11 Proteine) activation.
This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1 (zeige MAP3K1 Proteine)-p38 (zeige MAPK14 Proteine), disrupts heterochromatin.
ATF-2 is critical for regulation of fat metabolism.
dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1 (zeige AFT1 Proteine)/2, and indicates a difference between short and long isoforms.
Ang II (zeige AGT Proteine) increases endothelial arginase activity/expression through a p38 MAPK (zeige MAPK14 Proteine)/ATF-2 pathway leading to reduced endothelial NO production
Data indicate that Ser738/742-to-glutamate (zeige GRIN2A Proteine) protein kinase D (zeige PRKD1 Proteine) mutant increased AngII-induced CREB (zeige CREB1 Proteine) protein and activating transcription factor 2 phosphorylation, and phospho-CREB (zeige CREB1 Proteine) binding to the steroidogenic acute regulatory protein (zeige STAR Proteine) promoter.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (zeige PRKAA1 Proteine)/PPARalpha (zeige PPARA Proteine)/ATF2 pathway.
Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting were used to detect the mRNA and protein expressions of p-p38MAPK (zeige MAPK14 Proteine), AAT (zeige SERPINA1A Proteine), signal transducer and activator of transcription 1 (STAT1 (zeige STAT1 Proteine)) and activating transcription factor2 (ATF2)
increased expression of the gene encoding PKCepsilon (zeige PRKCE Proteine) and abundance of phosphorylated, transcriptionally active ATF2 were observed in advanced-stage melanomas and correlated with decreased FUK (zeige FUK Proteine) expression
These data identified a role for ATF2 in regulating melanocyte responses.
suppression of tumorigenesis by JNK (zeige MAPK8 Proteine) requires ATF2.
Taken together, our observations indicated that SOCS2 (zeige SOCS2 Proteine) could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (zeige MAPK14 Proteine) signal pathway.
ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 (zeige ATF3 Proteine) in M1 macrophages of White adipose tissue.
ATF-2 plays critical roles for proper expression of tyrosine hydroxylase (zeige TH Proteine) gene and for neurite extension of catecholaminergic neurons, possibly through repressor-like action.
these studies show that the IL-1beta (zeige IL1B Proteine)-induced increase in intestinal tight junction permeability was regulated by p38 (zeige CRK Proteine) kinase activation of ATF-2 and by ATF-2 regulation of MLCK (zeige MYLK Proteine) gene activity
ATF2-based luciferase reporter to monitor non-canonical Wnt (zeige WNT2 Proteine) signaling in Xenopus embryos.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro\; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Several alternatively spliced transcript variants have been found for this gene.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, activating transcription factor-2, isoform A
, activating transcription factor-2, isoform C
, activating transcription factor-2, isoform B
, cyclic AMP response element binding protein 2
, chimerin (chimaerin) 1