ATF2 Protein (His tag)

Produktnummer ABIN2715020

Produktdetails

Target: ATF2 (Activating Transcription Factor 2 (ATF2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ATF2 Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ATF2 (full length, N-term HIS tag) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ATF2 (Activating Transcription Factor 2 (ATF2))

Andere Bezeichnung: Atf2 (ATF2 Produkte)

Synonyme: CRE-BP1 Protein, CREB2 Protein, HB16 Protein, TREB7 Protein, CG12850 Protein, CG3749 Protein, dATF-2 Protein, DmelCG30420 Protein, CG30420 Protein, CHN1 Protein, Atf-2 Protein, CRE-BP Protein, Creb2 Protein, D130078H02Rik Protein, D18875 Protein, Tg(Gzma-Klra1)7Wum Protein, mXBP Protein, atf2-A Protein, atf2l Protein, activating transcription factor 2 Protein, Activating transcription factor-2 Protein, activating transcription factor 2 S homeolog Protein, ATF2 Protein, Atf-2 Protein, Atf2 Protein, atf2.S Protein, atf2 Protein

Hintergrund: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene

Molekulargewicht: 54.4 kDa

NCBI Accession: NP_001871

Pathways: MAPK Signalweg, RTK Signalweg, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades