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Mouse (Murine) C5A Protein expressed in Escherichia coli (E. coli) - ABIN413104
Jun, Lee, Song, Mansfield, Chou: G-CSF improves murine G6PC3-deficient neutrophil function by modulating apoptosis and energy homeostasis. in Blood 2011
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN413098
Nonaka, Bao, Matsumura, Götze, Kandasamy, Kononov, Broide, Nakayama, Seeberger, Fukuda: Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites. in Proceedings of the National Academy of Sciences of the United States of America 2014
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Human C5A Protein expressed in Escherichia coli (E. coli) - ABIN2506921
Yang, Radu, Wang, Riedinger, Witte: Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A. in Blood 2005
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Studies indicate that the complement response lie the active fragments, C3a (zeige C3 Proteine) and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Proteine), C5aR1 (zeige C5AR1 Proteine) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (zeige C5 Proteine) (C5) after binding to eculizumab in vivo.
TLR4 (zeige TLR4 Proteine) and C5aR (zeige C5AR1 Proteine) crosstalk in dendritic cells induces a core regulatory network of RSK2 (zeige RPS6KA3 Proteine), PI3Kbeta, SGK1 (zeige SGK1 Proteine), and FOXO (zeige FOXO3 Proteine) transcription factors.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 Proteine).
Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (zeige IL8 Proteine) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (zeige IL8 Proteine) expression via PI3K (zeige PIK3CA Proteine) and MEK (zeige MAP2K1 Proteine). Study demonstrated expression of IL-8 (zeige IL8 Proteine) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.
Reducing RPS19 (zeige RPS19 Proteine) in tumor cells or blocking the C5a receptor 1-RPS19 (zeige RPS19 Proteine) interaction decreases RPS19 (zeige RPS19 Proteine)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer
C5aR (zeige C5AR1 Proteine) expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.
this study shows that downregulation of CD88 (zeige C5AR1 Proteine) after stimulation with IL-8 (zeige IL8 Proteine) is more pronounced in adults than in neonates, whereas fMLP (zeige FPR1 Proteine) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (zeige AKT1 Proteine) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (zeige AKT1 Proteine) in heart.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (zeige CASP3 Proteine) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
The C5a/C5aR pathway is essential for up-regulating SphK1 (zeige SPHK1 Proteine) expression through p38 MAPK (zeige MAPK14 Proteine) activation in acute liver failure.in mice.
We induced anti-myeloperoxidase (zeige MPO Proteine) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (zeige IL17A Proteine)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (zeige C5AR1 Proteine) (complement C5a/anaphylatoxin (zeige C5 Proteine) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (zeige CPB2 Proteine) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (zeige C5AR1 Proteine), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (zeige CCL1 Proteine) monocyte chemoattractant protein-1 (zeige CCL2 Proteine) in hepatic metastases of colon cancer
Properdin (zeige CFB Proteine) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (zeige IL6 Proteine)-dependent manner.
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
, complement C5
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, C5a anaphylatoxin chemotactic receptor 1
, C5a anaphylatoxin receptor
, C5a ligand
, complement component 5 receptor 1