C5A Produkte
(Complement Component 5a (C5a))
Kategorien
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Ausgewählte C5A Kategorien
C5A Antikörper
High quality antibodies with extensive validation data.
C5A ELISA Kits
Reliable ELISA kits for a wide range of species.
C5A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene C5A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (9)
Kat. Nr.
ABIN7442321
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (5)
Kat. Nr.
ABIN7427906
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Mouse, Rat
Applikation
WB, IHC (p)
Validierungen
- (6)
Kat. Nr.
ABIN3029692
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene C5A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (6)
- (1)
Kat. Nr.
ABIN6955014
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (3)
- (1)
Kat. Nr.
ABIN6955015
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (4)
- (1)
Kat. Nr.
ABIN6955017
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene C5A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7274012
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7122470
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (2)
Kat. Nr.
ABIN2180666
Menge
50 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren C5A Produkten
: "C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis." in: Frontiers in immunology, Vol. 10, pp. 1866, (2020) (PubMed).: "C5aR deficiency attenuates the breast cancer development via the p38/p21 axis." in: Aging, Vol. 12, Issue 14, pp. 14285-14299, (2020) (PubMed).
: "Inhibition of osteoclast activity by complement regulation with DF3016A, a novel small-molecular-weight C5aR inhibitor." in: Biomedicine & pharmacotherapy, Vol. 123, pp. 109764, (2020) (PubMed).
: "Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression." in: Cancer letters, Vol. 412, pp. 30-36, (2017) (PubMed).
: "Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?" in: Gynecologic and obstetric investigation, Vol. 81, Issue 1, pp. 28-33, (2016) (PubMed).
: "Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery." in: International immunopharmacology, Vol. 32, pp. 66-75, (2016) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." in: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia." in: Environmental pollution (Barking, Essex : 1987), Vol. 218, pp. 770-782, (2016) (PubMed).
: "Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings." in: Biomacromolecules, Vol. 16, Issue 3, pp. 992-1001, (2015) (PubMed).
: "Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice." in: Toxicology and applied pharmacology, Vol. 287, Issue 1, pp. 86-92, (2015) (PubMed).
Synonyme und alternative Namen zu C5A
complement C5 (C5), C5a, C5b, CPAMD4, Hc, RGD1561905Bezeichner auf Proteinebene für C5A
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
- C5a anaphylatoxin
- anaphylatoxin C5a analog
- complement C5
- prepro-C5
- anaphylatoxin
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