STAT3 Proteine (STAT3)

Bezeichnung:
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Proteine (STAT3)
Auf www.antikoerper-online.de finden Sie aktuell 34 Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STAT3 Antikörper (622) und STAT3 Kits (56) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 740 STAT3 Produkte verfügbar.
Synonyme:
1110034C02Rik, aprf, AW109958, hies, stat3, wu:fc15d02, wu:fl59g06, Xstat3, z-Stat3
alle Proteine anzeigen Gen GeneID UniProt
STAT3 20848 P42227
STAT3 6774 P40763
STAT3 25125 P52631

Weitere Synonyme anzeigen

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Am meisten referenzierte STAT3 Proteine

  1. Human STAT3 Protein expressed in Wheat germ - ABIN1321594 : Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014 (PubMed)
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Weitere Proteine zu STAT3 Interaktionspartnern

Mouse (Murine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. We revealed that in mouse mesench (zeige IFNG Proteine)ymal stem cells IFN-gamma-induced immunoregulation is mediated by early phosphorylation of signal transducer and activator of transcription (STAT) 1 and STAT3, which is significantly enhanced by an extracellular signal-regulated kinase 1/2-dependent mTOR inhibition, thereby promoting pSTAT1 nuclear translocation.

  2. our data demonstrate that p66a may physically interact with STAT3 to suppress its activity through posttranslational modification, which reveals a novel regulatory mechanism controlling STAT3 activation during myeloid cell differentiation.

  3. Myeloid deletion of Cul3 (zeige CUL3 Proteine) led to defective STAT3 phosphorylation in colon macrophages, which was accompanied by exacerbated colonic inflammation and inflammation-driven tumorigenesis.

  4. High levels of miR-17 expression can function to up-regulate autophagy to aggravate hepatic ischemia/reperfusion injury by suppressing Stat3 expression.

  5. TRAF6 (zeige TRAF6 Proteine) mediates lysine-63 ubiquitination within the SH2 domain of STAT3, which is an essential step for STAT3 membrane recruitment and phosphorylation in response to S Typhimurium infection; results reveal a strategy in which S Typhimurium T3SS effectors broaden their functions through the activation of host proteins in a ubiquitination-dependent manner to manipulate host cells into becoming a Salmonella-friendly zone

  6. Small-scale in vivo screening identified several genes, including Cd109 (zeige CD109 Proteine), that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109 (zeige CD109 Proteine)-driven lung cancer metastasis

  7. the effect of STAT3 mutations on protein stability, is reported.

  8. Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C (zeige VEGFC Proteine) induction and lymphangiogenesis may involve, at least in part, Src (zeige SRC Proteine)-FAK (zeige PTK2 Proteine)-STAT3 cascade in lymphatic endothelial cells (LECs).

  9. miR (zeige MLXIP Proteine)-155 not only directly inhibited SOCS1 (zeige SOCS1 Proteine) expression, but also increased the expression of p-STAT (zeige STAT1 Proteine) and PDCD4 (zeige PDCD4 Proteine), as well as the production of proinflammation mediators IL-6 (zeige IL6 Proteine) and TNF-alpha (zeige TNF Proteine) in atherogenesis

  10. High STAT3 expression is associated with Hepatic Fibrosis.

Human Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. The results suggested the possible participation of STAT3 instead of ERK (zeige EPHB2 Proteine) in the GPR110 (zeige GPR110 Proteine) signaling pathways and progression of glioma.

  2. Results indicate a pathway via which microRNA miR-17-5p inhibits STAT3 and increases p53 (zeige TP53 Proteine) expression to promote apoptosis in breast cancer cells.

  3. These results suggest that it may be possible for Evista to emerge as a chemoprevention agent for breast cancer and other cancers such as colon cancer or multiple myeoloma by targeting IL-6 (zeige IL6 Proteine)/STAT3 signaling.

  4. A sustained exposure to IFN-gamma (zeige IFNG Proteine) in human mesenchymal stem cells led to inhibition of STAT3 activity.

  5. STAT3 activation promotes ERBIN (zeige ERBB2IP Proteine) expression and negatively regulates TGF-beta (zeige TGFB1 Proteine) activity by the formation of a STAT3-ERBIN (zeige ERBB2IP Proteine)-SMAD2 (zeige SMAD2 Proteine)/3 complex.

  6. IFITM2 (zeige IFITM2 Proteine) promotes gastric cancer growth and metastasis via IGF1 (zeige IGF1 Proteine)/IGF1R (zeige IGF1R Proteine)/STAT3 signaling pathway.

  7. Data show that succinate upregulates vascular endothelial growth factor (VEGF) expression by activation of signal transducer and activator of transcription 3 (STAT3) and extracellular regulated kinase (ERK)1 (zeige MAPK3 Proteine)/2 via its receptor G-protein coupled receptor 91 (GPR91 (zeige SUCNR1 Proteine)).

  8. Data show that cisplatin suppresses cervical cancer cell movement and angiogenesis via regulating miR (zeige MLXIP Proteine)-29b/STAT3 axis.

  9. Suppression of GPRC5a (zeige GPRC5A Proteine) results in decreased cell growth, proliferation and migration in pancreatic cancer cell lines via a STAT3 modulated pathway, independent from ERK (zeige EPHB2 Proteine) activation

  10. STAT3 expression is upregulated in both HBV- and HCV-related hepatocellular carcinoma (HCC (zeige FAM126A Proteine)), while hexokinase II (HK-II (zeige HK2 Proteine)) is predominantly upregulated and correlated to STAT3 in HBV-related HCC (zeige FAM126A Proteine)

Cow (Bovine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.

  2. Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate

  3. results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 proteins in bovine articular chondrocytes

  4. peroxynitrite causes increased expression of VEGF (zeige VEGFA Proteine) in vascular endothelial cells by a process that requires the activation of STAT3

  5. Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (zeige NOX1 Proteine)-mediated activation of STAT3.

Pig (Porcine) Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets

  2. maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Proteine) and PSEN1 (zeige PSEN1 Proteine) genes via a STAT3-dependent pathway

  3. Studied effect of recombinant porcine leukemia inhibitory factor (zeige LIF Proteine) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.

  4. Data suggest that IL-6 (interleukin 6 (zeige IL6 Proteine)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (zeige IL6 Proteine)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).

  5. the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.

  6. Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.

  7. STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways

  8. Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.

Rabbit Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. This is the first report of the genetic polymorphisms of the JAK1 (zeige JAK1 Proteine) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.

Guinea Pig Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.

  2. Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (zeige MMP2 Proteine) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.

Zebrafish Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) Interaktionspartner

  1. Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (zeige CDC25A Proteine) expression during oogenesis. Accordingly, restoring Cdc25a (zeige CDC25A Proteine) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.

  2. PTPN9 (zeige PTPN9 Proteine) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (zeige GATA1 Proteine) and ZBP-89 (zeige ZNF148 Proteine).

  3. Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.

  4. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.

  5. This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.

  6. The results of this study suggested that the stat3/socs3 (zeige SOCS3 Proteine) pathway is a key response in all tissue regeneration in zebrafish.

  7. stat3, a known oncogene (zeige RAB1A Proteine) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.

  8. Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (zeige PRCP Proteine) in neighboring cells during zebrafish gastrulation.

STAT3 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with STAT3

  • signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3)
  • signal transduction and activation of transcription 3 (stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (stat3)
  • signal transducer and activator of transcription 3 (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor) (Stat3)
  • signal transducer and activator of transcription 3 (acute-phase response factor), gene 1 (stat3.1)
  • 1110034C02Rik Protein
  • aprf Protein
  • AW109958 Protein
  • hies Protein
  • stat3 Protein
  • wu:fc15d02 Protein
  • wu:fl59g06 Protein
  • Xstat3 Protein
  • z-Stat3 Protein

Bezeichner auf Proteinebene für STAT3

signal transducer and activator of transcription 3 (acute-phase response factor) , signal transducer and activator of transcription 3 , signal transduction and activation of transcription 3 , Signal transducer and activator of transcription 3 , signal transducer and activator of transcription 3-like , acute phase response factor , acute-phase response factor , DNA-binding protein APRF , Protein Stat3 , signal transducer and activator of transcription 3.1 , stat 3

GENE ID SPEZIES
100011382 Monodelphis domestica
100171541 Pongo abelii
100380714 Salmo salar
100469938 Ailuropoda melanoleuca
100566559 Anolis carolinensis
100598877 Nomascus leucogenys
20848 Mus musculus
6774 Homo sapiens
25125 Rattus norvegicus
490967 Canis lupus familiaris
508541 Bos taurus
733648 Sus scrofa
420027 Gallus gallus
574128 Macaca mulatta
454682 Pan troglodytes
100348778 Oryctolagus cuniculus
100717084 Cavia porcellus
100294659 Ovis aries
779100 Xenopus laevis
30767 Danio rerio
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