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Human STAT3 Protein expressed in Wheat germ - ABIN1321594
Qian, Chai, Liang, Wang, Zhou, Xu, Zhang, Zhang, Si, Huang, Huang, Hong, Wang: KIF5B-RET fusion kinase promotes cell growth by multilevel activation of STAT3 in lung cancer. in Molecular cancer 2014
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ginsenoside Rb2 (zeige RBL2 Proteine) inhibits osteoclast differentiation by blocking NF-kappaB (zeige NFKB1 Proteine) and STAT3 signaling pathways.
The activation of STAT3 was much higher in Gal12 (zeige LGALS12 Proteine)(-/-) macrophages activated by lipopolysaccharide, which was correlated with higher levels of IL-10 (zeige IL10 Proteine). Adipocytes showed higher insulin (zeige INS Proteine) sensitivity when treated with Gal12 (zeige LGALS12 Proteine)(-/-) macrophage-conditioned media than those treated with Gal12 (zeige LGALS12 Proteine)(+/+) macrophages.
After Dox treatment, the protein expression of p-Jak2 (zeige JAK2 Proteine) and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2 (zeige JAK2 Proteine)/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity
Studied effect of Coptis Chinensis on glioma cells; results showed Coptis Chinensis induced cell cycle arrest and apoptosis in glioma cells, down-regulated the signal transducer and activator oftranscription 3 (STAT3) phosphorylation levels, and reduced the expression of histone deacetylase 3 (HDAC3 (zeige HDAC3 Proteine)).
M1 macrophages with inhibited STAT3, STAT6 (zeige STAT6 Proteine) and/or SMAD3 (zeige SMAD3 Proteine) effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology.
Our data suggest that the inhibition of sRAGE on I/R-induced apoptosis is associated with activation and expression of proteasome, including improved proteasome activity and elevated beta1i (zeige PSMB9 Proteine) and beta5i expression mediated by STAT3 activation. We predict that sRAGE is a novel intervention to target UPS activation for preventing and treating myocardial apoptosis.
our data indicate that luteolin diminishes the proinflammatory mediators NO, inflammatory cytokines and the expression of their regulatory genes, iNOS (zeige NOS2 Proteine) and COX-2, in PRV-infected RAW264.7 cells by inhibiting STAT1 (zeige STAT1 Proteine)/3 dependent NF-kappaB (zeige NFKB1 Proteine) activation and inducing Nrf2mediated HO-1 (zeige HMOX1 Proteine) expression.
activation of beta2-AR accelerated hepatocyte proliferation and improved recellularized liver function by mediating the IL-6 (zeige IL6 Proteine)/Stat 3 signalling pathway, indicating that nervous system regulation may be an essential component contributing to the complexity of recellularized liver in tissue engineering
Stat3 mediates the expression of iNOS (zeige NOS2 Proteine) to promote IFNgamma/TNFalpha (zeige TNF Proteine)-induced muscle atrophy.
BMI1 (zeige BMI1 Proteine) and MEL18 (zeige PCGF2 Proteine) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells.
G-rich sequences in the STAT3 gene could form G-quadruplexes under near physiological conditions.
nuclear localization of pSTAT3 in leukemic cells may have a role in hematopoietic stem cell transplant-associated large granular lymphocytic leukemia
CD36 (zeige CD36 Proteine)/STAT3 SNPs linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects.
Acquired lapatinib-resistant HER2 (zeige ERBB2 Proteine)-positive breast cancer cells had elevated IL-6 (zeige IL6 Proteine), and that elevated IL-6 (zeige IL6 Proteine) maintained the stemness population and property within these resistant cells through the activation of STAT3.
STAT3/STAT1 (zeige STAT1 Proteine) ratios are better clinical predictors in Colorectal carcinoma as compared to STAT3 or STAT1 (zeige STAT1 Proteine) levels alone.
Multilayer OMIC data analysis uncovered methylation hallmarks in genetically defined Medullary thyroid carcinoma (MTC (zeige MT1A Proteine)) and revealed JAK (zeige JAK3 Proteine)/Stat (zeige STAT1 Proteine) signaling effector STAT3 as a potential therapeutic target for the treatment of RET (zeige RET Proteine)(M918T) MTCs
Suggest a positive feedback mechanism via the STAT1 (zeige STAT1 Proteine)/3 pathway sustains cytokine production and reveal a reciprocal regulatory role of JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) in TNFalpha (zeige TNF Proteine)-mediated senescence.
the EGFR (zeige EGFR Proteine)/STAT3 pathway contributed to CDDP-induced CEBPD (zeige CEBPD Proteine) expression in UCUB cells. Gefitinib and S3I-201 treatment significantly reduced the expression of CEBPD (zeige CEBPD Proteine) and enhanced the sensitivity of CDDP-resistant UCUB cells to CDDP and paclitaxel
Primary open angle glaucoma in type 2 diabetes: Implications of the IL-10 (zeige IL10 Proteine)/STAT3-mediated anti-inflammatory response
Our study supports the development of strategies targeting STAT3 inhibition in combination with conventional chemotherapy for patients with high-risk neuroblastoma (zeige ARHGEF16 Proteine)
STA3 (zeige ARHGEF3 Proteine) facilitates TLR4 (zeige TLR4 Proteine)-dependent IL-6 (zeige IL6 Proteine) and IL-8 (zeige IL8 Proteine) production via IL-6 (zeige IL6 Proteine) receptor-positive feedback in endometrial cells.
STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection.
Single-SNP analysis revealed a statistically significant association between SNP25402 in STAT3 and fertilization rate
results show for the first time that interleukin-6 (zeige IL6 Proteine) (IL), in the presence of its soluble receptor (zeige IFNAR1 Proteine) (sIL-6R), induces activation of JAK1 (zeige JAK1 Proteine), JAK2 (zeige JAK2 Proteine), and STAT1 (zeige STAT1 Proteine)/STAT3 proteins in bovine articular chondrocytes
peroxynitrite causes increased expression of VEGF (zeige VEGFA Proteine) in vascular endothelial cells by a process that requires the activation of STAT3
Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase (zeige NOX1 Proteine)-mediated activation of STAT3.
this study shows that weaning caused severe inflammation associated with activation of the STAT3 pathway in the jejunum of piglets
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 (zeige CCND2 Proteine) and PSEN1 (zeige PSEN1 Proteine) genes via a STAT3-dependent pathway
Studied effect of recombinant porcine leukemia inhibitory factor (zeige LIF Proteine) on in vitro maturation of porcine oocytes; p-STAT3 markedly increased in both cumulus cells and oocytes cultured in pLIF (zeige FTH1 Proteine)-supplemented media.
Data suggest that IL-6 (interleukin 6 (zeige IL6 Proteine)) prevents apoptosis in blastocysts (here, parthenotes) and enhances blastocyst/embryo viability through IL-6 (zeige IL6 Proteine)/STAT3 signaling pathway (including up-regulation of STAT3 expression and phosphorylation).
the distribution of tyrosine phosphorylated signal transducer and activator of transcription 3.
Mitochondrial STAT3 activation has a causal role in mediating ischemic postconditioning cardioprotection through better mitochondrial function.
STAT3 is likely altering mitochondrial function via transcriptional regulation or indirect signaling pathways
Nuclear translocation of activated STAT3 and binding to STAT3 consensus DNA sequence were increased in the atrial fibrillation (AF) group.
This is the first report of the genetic polymorphisms of the JAK1 (zeige JAK1 Proteine) and STAT3 genes and their associations with the incidence of non-specific digestive disorder in rabbits.
Studied the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
Activation of Stat3 signaling pathway may be involved in up-modulating the expression of MMP-2 (zeige MMP2 Proteine) in guinea pig sclera fibroblasts, and not affect integrinbeta(1) expression.
Stat3 regulates cell proliferation and axis extension in part via upregulation of Cdc25a (zeige CDC25A Proteine) expression during oogenesis. Accordingly, restoring Cdc25a (zeige CDC25A Proteine) expression in stat3 mutants partially suppressed cell proliferation and gastrulation defects.
PTPN9 (zeige PTPN9 Proteine) plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 (zeige GATA1 Proteine) and ZBP-89 (zeige ZNF148 Proteine).
Stat3-Efemp2a modulates the fibrillar matrix for cohesive movement of prechordal plate progenitors.
Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth.
This study demonistrated that Stat3 is necessary for the maximal number of Muller glia to proliferate during regeneration of the damaged zebrafish retina.
The results of this study suggested that the stat3/socs3 (zeige SOCS3 Proteine) pathway is a key response in all tissue regeneration in zebrafish.
stat3, a known oncogene (zeige RAB1A Proteine) and a target of ss-catenin in multiple tissues, is upregulated in apc mutant zebrafish embryos.
Cells undergoing convergence and extension movement may sense the gradient of signaling molecules, which are expressed in gastrula organizer by STAT3 and activate PCP (zeige PRCP Proteine) in neighboring cells during zebrafish gastrulation.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
signal transducer and activator of transcription 3 (acute-phase response factor)
, signal transducer and activator of transcription 3
, signal transduction and activation of transcription 3
, Signal transducer and activator of transcription 3
, signal transducer and activator of transcription 3-like
, acute phase response factor
, acute-phase response factor
, DNA-binding protein APRF
, Protein Stat3
, signal transducer and activator of transcription 3.1
, stat 3