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anti-Human SOCS3 Antikörper:
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anti-Rat (Rattus) SOCS3 Antikörper:
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Human Polyclonal SOCS3 Primary Antibody für ELISA, IF (p) - ABIN670416
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
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Human Monoclonal SOCS3 Primary Antibody für ELISA, WB - ABIN2476543
Rychlíková, Démant: Influence of non-H-2 genotype on the response to H-2-linked mixed lymphocyte reaction stimulating (MLR-S) genes. in Folia biologica 1975
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Human Polyclonal SOCS3 Primary Antibody für IHC, IHC (p) - ABIN4355049
Harris, Apolzan: Hexosamine biosynthetic pathway activity in leptin resistant sucrose-drinking rats. in Physiology & behavior 2014
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Human Monoclonal SOCS3 Primary Antibody für WB - ABIN153119
Xiang, Dong, Liu, Wang, Shi, Wei, Hu, Gong: Inhibitory effects of suppressor of cytokine signaling 3 on inflammatory cytokine expression and migration and proliferation of IL-6/IFN-?-induced vascular smooth muscle cells. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2013
Human Monoclonal SOCS3 Primary Antibody für WB - ABIN94467
Neuwirt, Puhr, Cavarretta, Mitterberger, Hobisch, Culig: Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion. in Endocrine-related cancer 2007
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Human Polyclonal SOCS3 Primary Antibody für ELISA, WB - ABIN262251
Roberts, Robb, Rakar, Hartley, Cluse, Nicola, Metcalf, Hilton, Alexander: Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. in Proceedings of the National Academy of Sciences of the United States of America 2001
Human Polyclonal SOCS3 Primary Antibody für WB - ABIN1883384
Kim, Kim, Liu, Cao, Chen: Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. in The Journal of biological chemistry 2008
Human Monoclonal SOCS3 Primary Antibody für IF, IHC (p) - ABIN522456
Pierconti, Martini, Pinto, Cenci, Capodimonti, Calarco, Bassi, Larocca: Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior. in The Prostate 2011
Human Polyclonal SOCS3 Primary Antibody für IHC, ELISA - ABIN1585262
van de Loo, Veenbergen, van den Brand, Bennink, Blaney-Davidson, Arntz, van Beuningen, van der Kraan, van den Berg: Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function. in Arthritis and rheumatism 2012
we report the surprising finding that zebrafish respond to optic nerve lesion by inducing the expression of Sfpq (zeige SFPQ Antikörper) and Socs3a
stat3 (zeige STAT3 Antikörper)/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Trpm7 (zeige TRPM7 Antikörper) regulates exocrine pancreatic development via the Mg(2 (zeige MCOLN1 Antikörper)+)-sensitive Socs3a pathway.
SOCS3 expression in response to trauma is unaffected by blockade of the mitogen-activated protein kinase (zeige MAPK1 Antikörper) pathway by chemical inhibitors
The suppressor of cytokine signaling 3 gene was identified in this species, and the base sequence and deduced amino acid sequence are presented.
in homozygotes, GH signaling is reduced by the action of the SOCS1 (zeige SOCS1 Antikörper) and SOCS3 proteins.
Data suggest that SOCS3 is an important signaling protein in CLL, and Hsp90 (zeige HSP90 Antikörper) inhibitors represent an approach to target transcriptional repression in B cell lymphoproliferative disorders.
6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiated the inhibitory effect of IFN-alpha (zeige IFNA Antikörper) on hepatocellular carcinoma cell proliferation through activation of the JAK (zeige JAK3 Antikörper)/STAT (zeige STAT1 Antikörper) signaling pathway by inhibiting SOCS3 expression.
SOCS3 was down-regulated in CML cell lines and most of BMNCs from CML patients, and the expression level of SOCS3 was associated with the inhibition of cell proliferation and drug resistance of CML cells.
SOCS3 is involved in suppression of Helicobacter pylori induced STAT3 (zeige STAT3 Antikörper) phosphorylation by docosahexaenoic acid pretreatment.
The increased miR (zeige MLXIP Antikörper)-203 expression is associated with the reduced anti-inflammatory mediator SOCS-3 expression and the increased endothelial adhesion molecule (zeige NCAM1 Antikörper) expression in maternal vessel endothelium in preeclampsia.
Our results show, for the first time, that SOCS-3 regulates leptin (zeige LEP Antikörper)-induced responses in cartilage
Studies indicate that suppressors of cytokine signaling (SOCS (zeige CISH Antikörper)) proteins CIS (zeige CISH Antikörper), SOCS1 (zeige SOCS1 Antikörper), and SOCS3 can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4 (zeige CD4 Antikörper)(+) T cells and the maturation of CD8 (zeige CD8A Antikörper)(+) T cells.
In M1-activated human monocyte-derived macrophages, SOCS3 silencing decreased expression of proinflammatory markers and increased M2 macrophage markers. SOCS3 knockdown radically affects the temporal dynamics of M1 macrophages' particle engulfment through increased PI3K and Ras-related C3 botulinum toxin substrate 1 (Rac1) activity. SOCS3 drives macrophage inflammatory responses and modulates key phagocytosis signaling.
The results of this study demonstrated that HBx of hepatitis B virus impairs interferon (zeige IFNA Antikörper) signaling via increased expression of SOCS3 and PP2A (zeige PPP2R4 Antikörper).
Overexpression of SOCS3 inhibited proliferation, migration, invasion and tumorigenic ability of colorectal cancer cells while increased cell apoptosis. Reduced expression of SOCS3 promoted the growth and metastasis of colorectal cancer.
SOCS3 is an important negative regulator of insulin (zeige INS Antikörper) signaling in porcine adipocytes.
Low SOCS3 expression is required for milk synthesis and proliferation of dairy cow mammary epithelial cells in vitro.
Monocytes obtained from cows with subclinical infection with MAP had upregulated expression of IL-10 (zeige IL10 Antikörper) and SOCS-3, which may have attenuated the capacity of mononuclear phagocytes to initiate inflammatory and adaptive immune responses.
Mechanistic analysis indicated that E47 (zeige TCF3 Antikörper) activated expression of the transcription factor Spi-B (zeige SPIB Antikörper) and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 (zeige FOXP3 Antikörper) expression. These findings demonstrate that the balance of Id3 (zeige ID3 Antikörper) and E47 (zeige TCF3 Antikörper) controls the maintenance of Foxp3 (zeige FOXP3 Antikörper) expression in Treg cells and, thus, contributes to Treg cell plasticity.
Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration.
Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects.
Findings indicate that inactivation of the Rb family proteins (Rb, p107 (zeige RBL1 Antikörper), and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO (zeige MRPS12 Antikörper)) HSCs.
Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein)
Cell type-specific, different roles for viral immediate early (zeige JUN Antikörper) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 (zeige SOCS1 Antikörper) and SOCS3 during murine cytomegalovirus infection.
oncostatin M (zeige OSM Antikörper) mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (zeige IL17A Antikörper) and IL-21 (zeige IL21 Antikörper); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3 (zeige STAT3 Antikörper), and STAT5 (zeige STAT5A Antikörper); observations suggest that OSM (zeige OSM Antikörper) can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3 (zeige STAT3 Antikörper), and STAT5 (zeige STAT5A Antikörper)
Results demonstrate a novel tunable form of cross-talk in which alveolar epithelial cells use Prostaglandin E2 (PGE2) as a signal to request SOCS3 from alveolar macrophages to dampen their endogenous inflammatory responses during infection.
Loss of SOCS3 significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 (zeige SOCS1 Antikörper) deficiency. We propose a model in which SOCS1 (zeige SOCS1 Antikörper) and SOCS3 operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
suppressor of cytokine signaling 3
, suppressor of cytokine signaling 3a
, STAT-induced STAT inhibitor 3
, cytokine-inducible SH2 protein 3
, cytokine signaling suppressor
, E2a-Pbx1 target gene in fibroblasts 10
, cytokine inducible SH2-containing protein 3
, suppressors of cytokine signaling 3