Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
Human SOCS1 ELISA Kit für Sandwich ELISA - ABIN422769
Ma, Xue, Wang, Shu, Zhang: MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells. in Clinical and experimental immunology 2015
Socs1a transgenic zebrafish have liver steatosis and insulin (zeige INS ELISA Kits) resistance.
Studies demonstrate a conserved role for SOCS1 in T cell development and suggest a novel T cell-independent function in embryonic myelopoiesis mediated, at least in part, via its effects on receptors using the Jak2 (zeige JAK2 ELISA Kits)-Stat5 (zeige STAT5B ELISA Kits) pathway.
in homozygotes, GH signaling is reduced by the action of the SOCS1 and SOCS3 (zeige SOCS3 ELISA Kits) proteins.
SOCS1 alleviates RhTRIM5alpha-mediated regulation in the late phase of HIV-1 life cycle probably due to the destabilization of RhTRIM5alpha.
The upregulation of SOCS-1 and SOCS-2 (zeige SOCS2 ELISA Kits) by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene (zeige RAB1A ELISA Kits).
MiRNA sponges against miR (zeige MLXIP ELISA Kits)-19 or miR (zeige MLXIP ELISA Kits)-155 inhibit the functions of these miRNAs and potentiate the induction of SOCS1 and p53 (zeige TP53 ELISA Kits) in mouse leukemia cells and in human myeloma cells.
Mutations of CREBBP (zeige CREBBP ELISA Kits) and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma; SOCS1 mutations were associated with better progression-free survival.
These results suggest that miR146a may regulate SOCS1/STAT3 (zeige STAT3 ELISA Kits) and cytokine signalling in monocytes, directing T-cell differentiation and balancing immune clearance and immune injury during chronic viral infection.
IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 (zeige SOCS3 ELISA Kits) or USP18 (zeige USP18 ELISA Kits).
This study evaluation the roles of SOCS1, the regulator of TLR9 (zeige TLR9 ELISA Kits), RIG-I (zeige DDX58 ELISA Kits), and CD152 (zeige CTLA4 ELISA Kits) in patients with liver fibrosis/cirrhosis; the use of polymorphisms as markers for genetic risk is reported.
SOCS1 rs33932899 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
Studies indicate that suppressors of cytokine signaling (SOCS (zeige CISH ELISA Kits)) proteins CIS (zeige CISH ELISA Kits), SOCS1, and SOCS3 (zeige SOCS3 ELISA Kits) can be considered the third immunocheckpoint molecules since they regulate cytokine signals that control the polarization of CD4 (zeige CD4 ELISA Kits)(+) T cells and the maturation of CD8 (zeige CD8A ELISA Kits)(+) T cells.
Results provide evidence that repression of SHP-1 (zeige PTPN6 ELISA Kits), SHP-2 (zeige PTPN11 ELISA Kits) and SOCS-1 gene expression in patient plasma cells supports the constitutive activation of the JAK (zeige JAK3 ELISA Kits)/STAT3 (zeige STAT3 ELISA Kits) pathway and probably leads to higher degrees of bone marrow invasion.
Suppressor of cytokine signaling 1 (SOCS1) expression was upregulated in sustained virological responses (SVR) patients compared with non-SVR patients based on a multiplex reverse transcription-polymerase chain reaction analysis. Peripheral blood SOCS1 expression before treatment was not associated with SVR in hepatitis C virus (HCV) genotype 1 patients treated with pegylated IFN-alpha (zeige IFNA ELISA Kits) and ribavirin.
Study conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function.
results indicate that SOCS1 is one of the essential molecules that maintain regulatory T cell stability, particularly under the inflammatory conditions in which APCs (zeige APCS ELISA Kits) are highly activated
The Stat3 (zeige STAT3 ELISA Kits) exerts its activity through the induction of miR (zeige MLXIP ELISA Kits)- 155, which suppresses suppressor of cytokine signaling (SOCS (zeige CISH ELISA Kits))1.
Cell type-specific, different roles for viral immediate early (zeige JUN ELISA Kits) or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 and SOCS3 (zeige SOCS3 ELISA Kits) during murine cytomegalovirus infection.
Loss of SOCS3 (zeige SOCS3 ELISA Kits) significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 deficiency. We propose a model in which SOCS1 and SOCS3 (zeige SOCS3 ELISA Kits) operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease
miR (zeige MLXIP ELISA Kits)-155 not only directly inhibited SOCS1 expression, but also increased the expression of p-STAT (zeige STAT1 ELISA Kits) and PDCD4 (zeige PDCD4 ELISA Kits), as well as the production of proinflammation mediators IL-6 (zeige IL6 ELISA Kits) and TNF-alpha (zeige TNF ELISA Kits) in atherogenesis.
TLR8 (zeige TLR8 ELISA Kits) coupling with SOCS-1 inhibits TLR7 (zeige TLR7 ELISA Kits)-mediated antiviral immunity during WNV infection in mice.
nectin-4 (zeige PVRL4 ELISA Kits) serves as a stimulatory co-receptor for the prolactin receptor (zeige PRLR ELISA Kits) by regulating the feedback inhibition of SOCS1 in the JAK2 (zeige JAK2 ELISA Kits)-STAT5a (zeige STAT5A ELISA Kits) signaling pathway
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
suppressor of cytokine signaling 1
, suppressor of cytokine signalling
, suppressor of cytokine signaling 1b
, suppressor of cytokine signaling 1-like protein
, JAK binding protein
, JAK-binding protein
, STAT induced SH3 protein 1
, STAT-induced STAT inhibitor 1
, Tec-interacting protein 3
, cytokine-inducible SH2 protein 1
, JAK2-binding protein
, cytokine inducible SH2-containing protein 1
, cytokine inducible SH2-containing protein 7