anti-Ratte (Rattus) IL6ST Antikörper für ELISA

Recommended IL6ST Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
  • CD130
  • CDW130
  • GP130
  • IL-6RB
  • 5133400A03Rik
  • AA389424
  • BB405851
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • NCR
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin 6 signal transducer
  • neutrophil migration
  • IL6ST
  • Il6st
  • il6st
  • LOC100349330
  • NM
Epitop
AA 4-618
29
29
19
15
15
15
15
14
13
13
9
5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Ratte (Rattus)
221
129
63
4
4
3
2
2
1
1
1
1
Wirt
Maus
142
112
72
5
3
2
Klonalität
Monoklonal
Konjugat
Dieser IL6ST Antikörper ist unkonjugiert
21
17
14
14
14
13
12
11
11
11
10
8
7
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Applikation
ELISA
187
124
61
31
26
19
17
14
13
12
11
11
6
6
5
3
2
2
2
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Produktnummer ABIN2001607
$ 218.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2649538 ELISA Rabbit IgG AA 4-618 Anmelden zum Anzeigen 108
1 ABIN2214290 ELISA Rabbit IgG AA 4-618 Anmelden zum Anzeigen Polyclonal
1 ABIN2692503 ELISA Rabbit IgG AA 4-618 Anmelden zum Anzeigen Polyclonal

General

Antigen Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
Epitop AA 4-618
(29), (29), (19), (15), (15), (15), (15), (14), (13), (13), (9), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Ratte (Rattus)
(221), (129), (63), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Wirt Maus
(142), (112), (72), (5), (3), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL6ST Antikörper ist unkonjugiert
(21), (17), (14), (14), (14), (13), (12), (11), (11), (11), (10), (8), (7), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation ELISA
(187), (124), (61), (31), (26), (19), (17), (14), (13), (12), (11), (11), (6), (6), (5), (3), (2), (2), (2), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL6ST Antikörper

Target Details IL6ST Anwendungsinformationen Handhabung Bilder
Spezifität Rat gp130 / CD130 / IL6ST
No cross-reactivity in WB and ELISA with
Human cell lysate (293 cell line)
Keine Kreuzreaktivität Human
Produktmerkmale This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat gp130 / CD130 / IL6ST (rR gp130 / CD130 / IL6ST, ABIN2009072 NP_001008725.2, Met 4-Glu 618,. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Reinigung purified by Protein A affinity chromatography
Sterilität 0.2 μm filtered
Immunogen Recombinant Rat gp130 / CD130 / IL6ST protein (ABIN2009072)
Klon 9D7A9
Isotyp IgG2b

Target Details IL6ST

Produktdetails anti-IL6ST Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung IL6ST (IL6ST Antibody Abstract)
Hintergrund Glycoprotein 130 (gp130), also known as IL6ST, IL6R-beta and CD130, is a common signal-transducing molecule shared by the functional receptor complexes of the IL-6 family of cytokines (IL-6, IL-11, leukemia inhibitory factor (LIF), granulocyte colonystimulating factor, ciliary neurotrophic factor, and cardiotrophin-1). It belongs to the class I cytokine receptor family, and was found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver. Mouse gp130 contains five fibronectin type-III domains, and one Ig-like C2-type (immunoglobulin-like) domain. gp130 is an important part of many different types of signaling complexes. It binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. This complex of 3 proteins then homodimerizes to form a hexameric complex which can produce downstream signals. Inactivation of gp130 is lethal to mice. The mice homozygous for a knock-in mutation in gp130 that leads to gp130-dependent signal transducers and activators of transcription (STAT) 1/3 hyperactivation develop a broad spectrum of hematopoietic abnormalities, including splenomegaly, lymphadenopathy, and thrombocytosis. gp130 is also involved in various human diseases, such as liver disease, coronary artery disease and myocardial infarction. Furthermore, gp130 is widely expressed in breast cancer cell lines and primary tumors, thus it have been implicated in constitutive STAT3 activation in breast cancer.
NCBI Accession NP_001008725.2
Pathways JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration

Anwendungsinformationen

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Handhabung Bilder zurück nach oben
Applikationshinweise ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat IL6ST. The detection limit for Rat IL6ST is approximately 0.039 ng/well.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Konservierungsmittel Without preservative
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Haltbarkeit 12 months