anti-Human IL6ST Antikörper für Functional Studies

Recommended IL6ST Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
  • CD130
  • CDW130
  • GP130
  • IL-6RB
  • 5133400A03Rik
  • AA389424
  • BB405851
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • NCR
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin 6 signal transducer
  • neutrophil migration
  • IL6ST
  • Il6st
  • il6st
  • LOC100349330
  • NM
Reaktivität
Human
204
114
56
4
4
3
2
2
1
1
1
1
Wirt
Maus
118
112
59
3
3
2
Klonalität
Monoklonal
Konjugat
Dieser IL6ST Antikörper ist unkonjugiert
17
15
14
11
11
9
9
8
8
8
8
7
6
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
147
120
62
31
26
19
17
14
11
10
8
6
4
4
3
2
2
2
2
1
1
1
Hersteller
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Bilder

Produktnummer ABIN1105849
297,00 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1105850 Func FACS Mouse IgG2a Anmelden zum Anzeigen B-R3 16
1 ABIN1105845 Func FACS Mouse IgG1 Anmelden zum Anzeigen B-K5 5
1 ABIN1105847 Func FACS IP WB Mouse IgG1 Anmelden zum Anzeigen B-P4 22
1 ABIN1105846 Func FACS Mouse IgG1 Anmelden zum Anzeigen B-P8 12
1 ABIN1722541 Func FACS IP WB Mouse IgG1 Anmelden zum Anzeigen B-S12
1 ABIN1722538 Func FACS IP IHC Mouse IgG1 Anmelden zum Anzeigen B-P8
1 ABIN1722539 Func FACS IP IHC ELISA WB Mouse IgG1 Anmelden zum Anzeigen B-P4
1 ABIN1722536 Func FACS ELISA Mouse IgG2a Anmelden zum Anzeigen B-R3
1 ABIN1722537 Func FACS Mouse IgG1 Anmelden zum Anzeigen B-K5

anti-IL6ST Antikörper für Functional Studies mit den meisten Publikationen

Ähnliche anti-IL6ST Antikörper

Applikation / Reaktivität Human
Biochemical Assay (BCA) 1 Antikörper
Blocking Peptide (BP) 2 Antikörper
Cytometry by Time of Flight (CyTOF) 1 Antikörper
Dot Blot (DB) 17 Antikörper
ELISA 50 Antikörper
ELISA (Capture) 2 Antikörper
ELISA (Detection) 2 Antikörper
Enzyme Immunoassay (EIA) 6 Antikörper
Flow Cytometry (FACS) 84 Antikörper
Functional Studies (Func) 10 Antikörper
Immunocytochemistry (ICC) 2 Antikörper
Immunofluorescence (IF) 10 Antikörper
Immunofluorescence (fixed cells) (IF/ICC) 2 Antikörper
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 26 Antikörper
Immunohistochemistry (IHC) 29 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 17 Antikörper
Immunoprecipitation (IP) 11 Antikörper
Neutralization (Neut) 4 Antikörper

General

Antigen Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
Reaktivität Human
(204), (114), (56), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Wirt Maus
(118), (112), (59), (3), (3), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL6ST Antikörper ist unkonjugiert
(17), (15), (14), (11), (11), (9), (9), (8), (8), (8), (8), (7), (6), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
(147), (120), (62), (31), (26), (19), (17), (14), (11), (10), (8), (6), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 20 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL6ST Antikörper

Target Details IL6ST Anwendungsinformationen Handhabung ProductDetails: References for anti-IL6ST antibody (ABIN1105849) Bilder
Spezifität Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Ion Exchange Chromatography
Sterilität 0.22 μm filtered
Immunogen Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Klon B-S12
Isotyp IgG1

Target Details IL6ST

Produktdetails anti-IL6ST Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-IL6ST antibody (ABIN1105849) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD130 / IL6ST (IL6ST Antibody Abstract)
Hintergrund IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gen-ID 3572
NCBI Accession NP_002175
UniProt P40189
Forschungsgebiet CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration

Anwendungsinformationen

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Handhabung ProductDetails: References for anti-IL6ST antibody (ABIN1105849) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen ProductDetails: References for anti-IL6ST antibody (ABIN1105849) Bilder zurück nach oben
Konzentration 1.0 mg/mL
Buffer Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
Konservierungsmittel Without preservative
Lagerung 4 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C.

ProductDetails: References for anti-IL6ST antibody (ABIN1105849)

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Dong, Lee, Zhang, Marshall, Gao, Ip: "Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling." in: Cancer research, Vol. 64, Issue 1, pp. 19-22, 2004

Ancey, Menet, Corbi, Fredj, Garcia, Rücker-Martin, Bescond, Morel, Wijdenes, Lecron, Potreau: "Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation." in: Cardiovascular research, Vol. 59, Issue 1, pp. 78-85, 2003

Giese, Au-Yeung, Herrmann, Diefenbach, Haan, Küster, Wortmann, Roderburg, Heinrich, Behrmann, Müller-Newen: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, 2003

Jover, Bort, Gómez-Lechón, Castell: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, 2002

Wang, Gu, Huang, Zhu, Zhou, Xie, Xu, Qiu, Zhang: "gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells." in: International immunology, Vol. 14, Issue 6, pp. 599-603, 2002

Ancey, Corbi, Froger, Delwail, Wijdenes, Gascan, Potreau, Lecron: "Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture." in: Cytokine, Vol. 18, Issue 4, pp. 199-205, 2002

Voisin, Bitard, Daburon, Moreau, Taupin: "Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13682-92, 2002

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, 2001

Kurth, Horsten, Pflanz, Timmermann, Küster, Dahmen, Tacken, Heinrich, Müller-Newen: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, 2000

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, 2000

Gu, De Vos, Rebouissou, Jourdan, Zhang, Rossi, Wijdenes, Klein: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, 2000

Autissier, De Vos, Liautard, Tupitsyn, Jacquet, Chavdia, Klein, Brochier, Gaillard: "Dimerization and activation of the common transducing chain (gp130) of the cytokines of the IL-6 family by mAb." in: International immunology, Vol. 10, Issue 12, pp. 1881-9, 1999

Kallen, Grötzinger, Lelièvre, Vollmer, Aasland, Renné, Müllberg, Myer zum Büschenfelde, Gascan, Rose-John: "Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6." in: The Journal of biological chemistry, Vol. 274, Issue 17, pp. 11859-67, 1999

Kurth, Horsten, Pflanz, Dahmen, Küster, Grötzinger, Heinrich, Müller-Newen: "Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1480-7, 1999

Hammacher, Richardson, Layton, Smith, Angus, Hilton, Nicola, Wijdenes, Simpson: "The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor." in: The Journal of biological chemistry, Vol. 273, Issue 35, pp. 22701-7, 1998

Rebouissou, Wijdenes, Autissier, Tarte, Costes, Liautard, Rossi, Brochier, Klein: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." in: Blood, Vol. 91, Issue 12, pp. 4727-37, 1998

Horsten, Müller-Newen, Gerhartz, Wollmer, Wijdenes, Heinrich, Grötzinger: "Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex." in: The Journal of biological chemistry, Vol. 272, Issue 38, pp. 23748-57, 1997

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, 1997

Simpson, Hammacher, Smith, Matthews, Ward: "Interleukin-6: structure-function relationships." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, 1997

Puthier, Bataille, Barillé, Mellerin, Harousseau, Ponzio, Robillard, Wijdenes, Amiot: "Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone." in: Blood, Vol. 88, Issue 12, pp. 4659-66, 1997

Bilder

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung ProductDetails: References for anti-IL6ST antibody (ABIN1105849) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-IL6ST Antikörper (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor)) (ABIN1105849) anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody