anti-Human IL6ST Antikörper für Functional Studies

Recommended IL6ST Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
  • CD130
  • CDW130
  • GP130
  • IL-6RB
  • 5133400A03Rik
  • AA389424
  • BB405851
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • NCR
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin 6 signal transducer
  • neutrophil migration
  • IL6ST
  • Il6st
  • il6st
  • LOC100349330
  • NM
Reaktivität
Human
220
129
64
4
4
3
2
2
1
1
1
1
Wirt
Maus
142
112
72
5
3
2
Klonalität
Monoklonal
Konjugat
Dieser IL6ST Antikörper ist unkonjugiert
21
17
14
14
14
13
12
11
11
11
10
8
7
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Applikation
Functional Studies (Func), Flow Cytometry (FACS)
186
124
62
31
26
19
17
14
13
12
11
10
6
6
5
3
2
2
2
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN1105846
$ 308.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1105847 Func FACS IP WB Mouse IgG1 Anmelden zum Anzeigen B-P4 22
1 ABIN1105849 Func FACS IP WB Mouse IgG1 Anmelden zum Anzeigen B-S12 22
1 ABIN1105850 Func FACS Mouse IgG2a Anmelden zum Anzeigen B-R3 16
1 ABIN1105845 Func FACS Mouse IgG1 Anmelden zum Anzeigen B-K5 5
1 ABIN1722541 Func FACS IP WB Mouse IgG1 Anmelden zum Anzeigen B-S12
1 ABIN1722537 Func FACS Mouse IgG1 Anmelden zum Anzeigen B-K5
1 ABIN1722538 Func FACS IP IHC Mouse IgG1 Anmelden zum Anzeigen B-P8
1 ABIN1722539 Func FACS IP IHC ELISA WB Mouse IgG1 Anmelden zum Anzeigen B-P4
1 ABIN1722536 Func FACS ELISA Mouse IgG2a Anmelden zum Anzeigen B-R3

General

Antigen Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
Reaktivität Human
(220), (129), (64), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Wirt Maus
(142), (112), (72), (5), (3), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL6ST Antikörper ist unkonjugiert
(21), (17), (14), (14), (14), (13), (12), (11), (11), (11), (10), (8), (7), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Functional Studies (Func), Flow Cytometry (FACS)
(186), (124), (62), (31), (26), (19), (17), (14), (13), (12), (11), (10), (6), (6), (5), (3), (2), (2), (2), (1), (1)
Pubmed 12 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL6ST Antikörper

Target Details IL6ST Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105846) Bilder
Spezifität Recognizes the soluble antigen. Recognizes the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Ion Exchange Chromatography.
Sterilität 0.22 μm filtered
Immunogen Natural soluble gp130. Hybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells.
Klon B-P8
Isotyp IgG1

Target Details IL6ST

Produktdetails anti-IL6ST Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105846) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD130 / IL6ST (IL6ST Antibody Abstract)
Hintergrund IL-6 activates intracellular signaling through binding a receptor consisting of an 80 kDa ligand-binding protein (IL-6R) and a second protein of 130 kDa. IL-6 first binds to IL-6R which subsequently associates with a gp130 dimer. The active signaling complex consists of at minimum IL-6, IL-6R and a dimer of two gp130 proteins that are linked by a disulfide bond. A soluble form of IL-6R is generated by proteolytic cleavage of the membrane-bound precursor and can function as an agonistic molecule that can actively participate in cell-tocell signaling. The second subunit of the IL-6 complex, gp130, also functions as a component of several additional receptor complexes including leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11. LIF binds to the LIF receptor with low affinity and to a complex of the LIF receptor and gp130 with high affinity, while OSM appears to bind to gp130 with low affinity and to a complex of gp130 and the LIF receptor with high affinity.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gen-ID 3572
NCBI Accession NP_002175
UniProt P40189
Forschungsgebiet CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration

Anwendungsinformationen

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105846) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Referenzen für anti-IL6ST Antikörper (ABIN1105846) Bilder zurück nach oben
Konzentration 1.0 mg/mL
Buffer Phosphate-buffered saline without Carrier and preservatives. This prodcut is sterile-filtered through 0.22 μm and treated to remove Endotoxins.
Konservierungsmittel Without preservative
Lagerung 4 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C.

Referenzen für anti-IL6ST Antikörper (ABIN1105846)

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Giese, Au-Yeung, Herrmann, Diefenbach, Haan, Küster, Wortmann, Roderburg, Heinrich, Behrmann, Müller-Newen: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, 2003

Timmermann, Küster, Kurth, Heinrich, Müller-Newen: "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor." in: European journal of biochemistry / FEBS, Vol. 269, Issue 11, pp. 2716-26, 2002

Aoki, Narazaki, Kishimoto, Tosato: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, 2001

Kurth, Horsten, Pflanz, Timmermann, Küster, Dahmen, Tacken, Heinrich, Müller-Newen: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, 2000

Olivier, Auguste, Chabbert, Lelièvre, Chevalier, Gascan: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, 2000

Rebouissou, Wijdenes, Autissier, Tarte, Costes, Liautard, Rossi, Brochier, Klein: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." in: Blood, Vol. 91, Issue 12, pp. 4727-37, 1998

Horsten, Müller-Newen, Gerhartz, Wollmer, Wijdenes, Heinrich, Grötzinger: "Molecular modeling-guided mutagenesis of the extracellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex." in: The Journal of biological chemistry, Vol. 272, Issue 38, pp. 23748-57, 1997

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, 1997

Simpson, Hammacher, Smith, Matthews, Ward: "Interleukin-6: structure-function relationships." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, 1997

Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, 1996

Gu, Wijdenes, Zhang, Hallet, Clement, Klein: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, 1996

Wijdenes, Heinrich, Müller-Newen, Roche, Gu, Clément, Klein: "Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies." in: European journal of immunology, Vol. 25, Issue 12, pp. 3474-81, 1996

Bilder

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105846) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody (ABIN1105846) anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody