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anti-Human IL6ST Antikörper:
anti-Mouse (Murine) IL6ST Antikörper:
anti-Rat (Rattus) IL6ST Antikörper:
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Human Monoclonal IL6ST Primary Antibody für FACS, IP - ABIN1383683
Wijdenes, Heinrich, Müller-Newen, Roche, Gu, Clément, Klein: Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies. in European journal of immunology 1996
Show all 26 Pubmed References
Human Monoclonal IL6ST Primary Antibody für FACS, IP - ABIN1383685
Fourcin, Chevalier, Guillet, Robledo, Froger, Pouplard-Barthelaix, Gascan: gp130 transducing receptor cross-linking is sufficient to induce interleukin-6 type responses. in The Journal of biological chemistry 1996
Show all 24 Pubmed References
Human Monoclonal IL6ST Primary Antibody für FACS - ABIN1383678
Gu, Wijdenes, Zhang, Hallet, Clement, Klein: Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M. in Journal of immunological methods 1996
Show all 19 Pubmed References
Human Monoclonal IL6ST Primary Antibody für FACS - ABIN1383682
Chevalier, Fourcin, Robledo, Wijdenes, Pouplard-Barthelaix, Gascan: Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein. in The Journal of biological chemistry 1996
Show all 15 Pubmed References
Human Monoclonal IL6ST Primary Antibody für FACS - ABIN1383681
Auguste, Guillet, Fourcin, Olivier, Veziers, Pouplard-Barthelaix, Gascan: Signaling of type II oncostatin M receptor. in The Journal of biological chemistry 1997
Show all 5 Pubmed References
Human Monoclonal IL6ST Primary Antibody für FACS - ABIN1383684
Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. in European journal of biochemistry / FEBS 1996
Show all 4 Pubmed References
Mouse (Murine) Monoclonal IL6ST Primary Antibody für FACS - ABIN4896627
Pratama, Srivastava, Williams, Papa, Lee, Dinh, Hutloff, Jordan, Zhao, Casellas, Athanasopoulos, Vinuesa: MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. in Nature communications 2015
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Mouse (Murine) Monoclonal IL6ST Primary Antibody für FACS - ABIN4896626
Nagashima, Okuyama, Hayashi, Ishii, So: TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Human Monoclonal IL6ST Primary Antibody für FACS - ABIN1383679
Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells. in Cancer research 2001
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Human Monoclonal IL6ST Primary Antibody für FACS - ABIN4897910
Larsen, Hansen, Møller, Madsen, Scheller, Nielsen, Petersen: Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. in Molecular and cellular biology 2010
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This functional mouse model of PMM2-CDG, in vitro assays and identification of the novel gp130 biomarker all shed light on the human disease, and moreover, provide the essential tools to test potential therapeutics for this untreatable disease.
we developed a CRISPR-Cas9-based tool for specific DNA methylation (zeige HELLS Antikörper) consisting of deactivated Cas9 (dCas9) nuclease (zeige DCLRE1C Antikörper) and catalytic domain of the DNA methyltransferase (zeige DNMT1 Antikörper) DNMT3A (zeige DNMT3A Antikörper) targeted by co-expression of a guide RNA to any 20 bp DNA sequence followed by the NGG trinucleotide.we demonstrated that directed DNA methylation (zeige HELLS Antikörper) of a wider promoter region of the target loci IL6ST and BACH2 (zeige BACH2 Antikörper) decreased their expression
data suggest that the different sgp130 forms are released from cells into their immediate surroundings and appear to form cell-associated gradients to modulate their own susceptibility for IL-6 (zeige IL6 Antikörper) trans-signaling.
Data indicate possible associations between pretransplant levels of CRP (zeige CRP Antikörper)/IL-6 /IL-6 (zeige IL6 Antikörper) receptor /gp130 and posttransplant outcomes.
Soluble glycoprotein 130 and hsp27 (zeige HSPB1 Antikörper) are novel candidate biomarkers for diagnosing Chronic Heart Failure with preserved ejection fraction and thus warrant further investigation; neither dpp4 (zeige DPP4 Antikörper) nor CTSS (zeige CTSS Antikörper) showed promise as biomarkers of Chronic Heart Failure.
Intracellular p19 (zeige CDKN2D Antikörper) associated with the cytokine receptor (zeige EBI3 Antikörper) subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3 (zeige STAT3 Antikörper)) signaling
High serum GP130 levels were associated with Chronic Spontaneous Urticaria.
PECs exhibited higher proliferation in response to IL-6 (zeige IL6 Antikörper)/sIL (zeige PMEL Antikörper)-6R co-treatment compared with TECs in HCC (zeige FAM126A Antikörper) via the up-regulation of gp130 /JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper).
Mutations leading to constitutive active gp130/JAK1 (zeige JAK1 Antikörper)/STAT3 (zeige STAT3 Antikörper) pathway.
In the present study, we analyze the role of a unique cysteine residue (Cys-628) within this C-terminus, which is contained neither in the membrane-bound gp130 nor in the two other sgp130 forms.
EBI3 can mediate IL-6 trans-signaling in a process that involves gp130
Blocking IL-6 (zeige IL6 Antikörper) trans-signaling in the CNS abrogates the ability of IL-6 (zeige IL6 Antikörper) to suppress feeding. Furthermore, gp130 (zeige LRPPRC Antikörper) expression is enhanced in the paraventricular nucleus of the hypothalamus (PVH) of obese mice, and deletion of gp130 (zeige LRPPRC Antikörper) in the PVH attenuates the beneficial central IL-6 (zeige IL6 Antikörper) effects on metabolism
C2C12 myotubes possesses a mechanism for regulating IL-6R and gp130 expression following lipoic acid treatment or heat shock.
Results suggest that the protective role of gp130 (zeige LRPPRC Antikörper)-dependent STAT3 (zeige STAT3 Antikörper) activation in experimental colitis involves the expansion and activation of mucosal myeloid-derived suppressor cells.
IL-6/gp130 signalling in the osteoclast is not essential for normal bone resorption in vivo, but maintains both trabecular and periosteal bone formation in male mice by promoting osteoblast activity through the stimulation of osteoclast-derived coupling factors and osteotransmitters
gp130 (zeige LRPPRC Antikörper)-mediated adipose tissue lipolysis promotes hepatic steatosis and insulin (zeige INS Antikörper) resistance.
differences exist in the expression of receptors utilized by the IL-6 (zeige IL6 Antikörper)/gp130 (zeige LRPPRC Antikörper) family of cytokines in astrocytes and microglia, and (2) the findings provide a molecular basis for the differential response to oncostatin M (zeige OSM Antikörper) by astrocytes versus microglia
Deregulation of gp130 (zeige LRPPRC Antikörper)/STAT3 (zeige STAT3 Antikörper) signalling augments the acute phase reponse and macrophage infiltration during atherosclerosis without impacting on the development of aortic plaques.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
IL-6sR and gp130 (zeige ANPEP Antikörper), but not IL-6R alpha (zeige IL6R Antikörper), play important roles in regulation of granulosa cell survival
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
, IL-6 receptor subunit beta
, IL-6R subunit beta
, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
, interleukin receptor beta chain
, interleukin-6 receptor subunit beta
, membrane glycoprotein 130
, membrane glycoprotein gp130
, oncostatin-M receptor subunit alpha
, interleukin-6 signal transducer
, interleukin 6 signal transducer
, glycoprotein 130
, LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta
, interleukin 6 signal transducer (gp130, oncostatin M receptor)
, interleukin 6 signal transducer receptor