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anti-Human KDM3A Antikörper:
anti-Mouse (Murine) KDM3A Antikörper:
anti-Rat (Rattus) KDM3A Antikörper:
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Human Polyclonal KDM3A Primary Antibody für IP, WB - ABIN262232
Javierre, Rodriguez-Ubreva, Al-Shahrour, Corominas, Graña, Ciudad, Agirre, Pisano, Valencia, Roman-Gomez, Calasanz, Prosper, Esteller, Gonzalez-Sarmiento, Ballestar: Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells. in Molecular cancer research : MCR 2011
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Human Monoclonal KDM3A Primary Antibody für IHC, ELISA - ABIN969228
Nagase, Ishikawa, Suyama, Kikuno, Miyajima, Tanaka, Kotani, Nomura, Ohara: Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. in DNA research : an international journal for rapid publication of reports on genes and genomes 1999
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Human Monoclonal KDM3A Primary Antibody für ICC, ELISA - ABIN969229
Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: Large-scale characterization of HeLa cell nuclear phosphoproteins. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal KDM3A Primary Antibody für ICC, IF - ABIN4332049
Kuroki, Matoba, Akiyoshi, Matsumura, Miyachi, Mise, Abe, Ogura, Wilhelm, Koopman, Nozaki, Kanai, Shinkai, Tachibana: Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. in Science (New York, N.Y.) 2013
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Cow (Bovine) Polyclonal KDM3A Primary Antibody für IHC, WB - ABIN2777661
Katoh, Katoh: Identification and characterization of TRIP8 gene in silico. in International journal of molecular medicine 2003
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Data suggest a critical role for KDM3A in the PI3K (zeige PIK3CA Antikörper)/AP-1 (zeige FOSB Antikörper) oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K (zeige PIK3CA Antikörper) pathway activation.
The authors find that KDM3A promotes anoikis through transcriptional activation of BNIP3 (zeige BNIP3 Antikörper) and BNIP3L (zeige BNIP3L Antikörper), which encode pro-apoptotic proteins.
The KDM3A to PRM1 (zeige PRM1 Antikörper) mRNA expression ratio can be used as a reliable marker of successful testicular sperm extraction in men with obstructive and non-obstructive azoospermia with 95% sensitivity.
Authors show that KDM3A regulates MCAM (zeige MCAM Antikörper) expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM (zeige MCAM Antikörper) promoter, and an indirect mechanism, via the Ets1 (zeige ETS1 Antikörper) transcription factor.
JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of HIF1alpha (zeige HIF1A Antikörper).
depletion of KDM3A was capable of reactivating mutated p53 (zeige TP53 Antikörper) to induce the expression of pro-apoptotic genes in breast cancer with mutant p53 (zeige TP53 Antikörper). KDM3A knockdown also potently inhibited tumorigenic potentials of breast cancer stem-like cells and rendered them sensitive to apoptosis induced by chemotherapeutic drugs.
our findings reveal a novel mechanism by which KDM3A promotes ovarian CSCs, proliferation and chemoresistance and thus, highlights the significance of KDM3A as a novel therapeutic target for resistant ovarian cancer.
a critical role for JMJD1A in regulating proliferation and survival of prostate cancer cells by controlling c-Myc (zeige MYC Antikörper) expression at transcriptional and post-translational levels
deficient expression of JMJD1A/JMJD1A might be reflecting and/or contributing to round spermatid maturation arrest
JMJD1A could promote non-small cell lung cancer tumorigenesis
Data suggest a critical role for KDM3A in the PI3K/AP-1 (zeige JUN Antikörper) oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K pathway activation.
JMJD1A is phosphorylated at S265 by protein kinase A (PKA), and this is pivotal to activate the beta1-adrenergic receptor gene (Adrb1 (zeige ADRB1 Antikörper)) and downstream targets including Ucp1 (zeige UCP1 Antikörper) in brown adipocytes.
Kdm3a localizes to cytoplasmic structures of maturing spermatids affected in Kdm3a mutant mice, which in turn display altered fractionation of beta-actin (zeige ACTB Antikörper) and gamma-tubulin (zeige TUBG1 Antikörper).
Results show that Jmjd1a was not essential for stem cell self-renewal but played a crucial role as a tumor suppressor.
Despite these differences in rats, genetic knockout of Kdm3a in mice resulted in no dramatic effect on immune system development and activation or EAE susceptibility and severity
Jmjd1a directly and positively controls Sry (zeige SRY Antikörper) expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.
Exposing cells to either chemical or cellular sources of (*)NO resulted in a significant increase in dimethyl Lys (zeige LYZ Antikörper)-9 on histone 3 (H3K9me2), the preferred substrate for KDM3A.
the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem (zeige CREM Antikörper)-regulated gene expression and spermatogenesis
TSGA may modulate the function of ER71 (zeige ETV2 Antikörper) and thereby affect spermatogenesis as well as embryonic development
Jmjd1a might be a critical signaling molecule underlying the maintenance of pluripotency in mouse embryonic stem cells
Histone demethylases KDM3A, KDM4A (zeige KDM4A Antikörper), and KDM4C (zeige KDM4C Antikörper) were expressed before and after embryonic genome activation, whereas KDM5B (zeige KDM5B Antikörper) was mainly expressed during the blastocyst period.
The histone H3 (zeige HIST3H3 Antikörper) lysine 9 demethylase (zeige MBD2 Antikörper) KDM3A facilitates the Xenopus Neurog2 (zeige NEUROG2 Antikörper) chromatin accessibility during neuronal transcription. Loss-of-function analyses reveal that KDM3A is not required for the transition of naive ectoderm to neural progenitor cells but is essential for primary neuron formation.
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants.
jmjC domain-containing histone demethylation protein 2A
, jumonji C domain-containing histone demethylase 2A
, jumonji domain containing 1
, jumonji domain containing 1A
, jumonji domain-containing protein 1A
, lysine-specific demethylase 3A
, testis-specific protein A
, lysine (K)-specific demethylase 3A
, testis specific gene A
, probable zinc finger protein
, testis-specific gene A protein
, zinc finger protein TSGA
, lysine-specific demethylase 3A-like
, jumonji domain-containing protein 1A-B
, lysine-specific demethylase 3A-B
, LOW QUALITY PROTEIN: lysine-specific demethylase 3A