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Human SMAD7 ELISA Kit für Sandwich ELISA - ABIN414598
Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients. in BMC immunology 2015
Smad7 expression in necrotizing enterocolitis macrophages interrupts TGF-beta (zeige TGFB1 ELISA Kits) signaling and promotes NF-kappaB (zeige NFKB1 ELISA Kits)-mediated inflammatory signaling in these cells through increased expression of IKK-beta (zeige IKBKB ELISA Kits)
SMAD7 gene and specifically the allele C could be protective for colorectal cancer (CRC (zeige CALR ELISA Kits)). An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC (zeige CALR ELISA Kits) risk.
Smad7 inhibition diminishes interaction of PKR (zeige PKLR ELISA Kits) with protein kinase inhibitor p58 (p58 (zeige DNAJC3 ELISA Kits)(IPK)).
Smad7 regulates TGF-beta1 (zeige TGFB1 ELISA Kits) signaling via a negative feedback loop and mediates the interaction between TGF-beta1 (zeige TGFB1 ELISA Kits) and other signaling pathways; suggesting that Smad7 over expression may have therapeutic potential in ALL.
Missense variant in smad7 gene is associated with colorectal cancer.
ASPP2 (zeige TP53BP2 ELISA Kits) suppresses invasion, peritoneal dissemination and TGF-beta1 (zeige TGFB1 ELISA Kits)-induced EMT (zeige ITK ELISA Kits) by inhibiting Smad7 degradation mediated by ITCH in gastric cancer cells.
Transforming Growth Factor beta inhibitor peptide P144 (zeige TCERG1 ELISA Kits) downregulates SKI (zeige SKI ELISA Kits) and an upregulates SMAD7 at both transcriptional and translational levels in glioblastoma cell lines.
The inverse correlation between Smad7 and AhR (zeige AHR ELISA Kits) expression helps to propagate inflammatory signals in the gut (zeige GUSB ELISA Kits) in Crohn's disease.
RNF11 (zeige RNF11 ELISA Kits) sequestration of the E3 ligase SMURF2 (zeige SMURF2 ELISA Kits) on membranes antagonizes SMAD7 down-regulation of transforming growth factor beta signaling
NR2F2 (zeige NR2F1 ELISA Kits) could promote TGF-beta (zeige TGFB1 ELISA Kits)-induced epithelial-mesenchymal transition of colorectal carcinoma cells and inhibit Smad7 expression via transactivation of miR (zeige MLXIP ELISA Kits)-21.
Smad7 plays a protective role in acute kidney injury by preventing tubular epithelial cells from the G1 cell cycle arrest.
study reports an alternately-spliced form of Smad7, Smad7Delta, that is induced by TGF-beta (zeige TGFB1 ELISA Kits) and CLIC4 (zeige CLIC4 ELISA Kits), is a dominant inhibitor of Smad7 and enhances TGF-beta (zeige TGFB1 ELISA Kits) signaling
Pancreatic depletion of SMAD7 resulted in age-dependent increases in beta cell dysfunction with accelerated glucose intolerance, followed by overt diabetes.
results indicate that miR (zeige MLXIP ELISA Kits)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) and Wnt (zeige WNT2 ELISA Kits) signaling pathway by directly targeting Smad7 and Tcf7l2 (zeige TCF7L2 ELISA Kits)
microRNA-497 modulates breast cancer cell proliferation, invasion, and survival by targeting SMAD7.
results indicate that miR (zeige MLXIP ELISA Kits)-195a-5p inhibits MTEC1 proliferation, at least in part, via down-regulation of Smad7
Data indicate that, in irritable bowel disease, high Smad7 contributes to sustain detrimental immune responses and knockdown of this molecule can help attenuate the ongoing mucosal inflammation in patients with such disorders
Hic-5 (zeige TGFB1I1 ELISA Kits) deficiency attenuates the activation of hepatic stellate cells and liver fibrosis though reducing the TGF-beta (zeige TGFB1 ELISA Kits)/Smad2 (zeige SMAD2 ELISA Kits) signaling by upregulation of Smad7
Data show that microRNA miR (zeige MLXIP ELISA Kits)-21 was significantly upregulated by bone morphogenetic protein 9 (BMP9 (zeige GDF2 ELISA Kits)) during the osteogenesis the multilineage cells (MMCs) by suppressing Smad7 protein.
Tril (zeige TRIL ELISA Kits) is a novel component of a Bmp-Gata2 (zeige GATA2 ELISA Kits) positive-feedback loop that plays an essential role in hematopoietic specification, by targeting Smad7 for degradation.
cTid1 can bind to other members of the Smad (zeige SMAD1 ELISA Kits) family and that highest binding activity occurs with the negative regulatory Smad7, through the conserved MH2 (zeige SCN4A ELISA Kits) domain
Smad7 has a role in Xenopus mesodermal and neural induction
SMAD7 plays a potentially important role in mammalian prenatal skeletal muscle development and is a candidate gene for promoting greater weaning weight in pig breeding.
MiR (zeige MYLIP ELISA Kits)-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene
a detailed computational model for TGF-beta (zeige TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 ELISA Kits)/5/8 and Smad2 (zeige SMAD2 ELISA Kits)/3 channels through a negative feedback loop dependent on Smad7.
Results suggest that myostatin (zeige MSTN ELISA Kits) auto-regulates its gene expression through a Smad7 dependent mechanism in myogenic cells.
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
MAD (mothers against decapentaplegic, Drosophila) homolog 7
, MAD homolog 8
, Mothers against decapentaplegic, drosophila, homolog of, 7
, SMAD, mothers against DPP homolog 7
, mothers against DPP homolog 8
, mothers against decapentaplegic homolog 7
, MAD homolog 7
, SMAD 7
, mothers against DPP homolog 7
, mothers against decapentaplegic homolog 8
, MAD, mothers against decapentaplegic homolog 7
, mothers against DPP 7
, mothers against decapentaplegic-like protein 7
, SMAD family member 7