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these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.
MIOX under high glucose ambience exacerbates renal injury during the progression of diabetic nephropathy following the generation of excessive reactive oxygen species via an unexplored glucuronate-xylulose pathway.
Data suggest that Miox expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of Miox activity is related to phosphorylation of serine/threonine residues.
MIOX expression attenuated tubular damage and improved renal function.
KSP-positive cells acquired the characteristics of each segment of renal tubular cells through tubular formation when stimulated with Wnt4 (zeige WNT4 ELISA Kits).
RSOR/MIOX modulates various downstream pathways affected by high-glucose ambience, and conceivably it plays a role in the pathobiology of tubulointerstitium in diabetic nephropathy.
Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa (zeige POLR2C ELISA Kits) protein.
RSOR activity is modulated by diverse mechanisms, and it is endowed with dual properties to channel glucose intermediaries, characteristic of hepatic aldehyde reductases, and to maintain osmoregulation, in diabetes.
These results indicate that MIOX is found at lower levels in extra-renal tissues where diabetic complications, including nephropathy, neuropathy, retinopathy, and cataract, are frequently observed.
Data demonstrate the formation of an antiferromagnetically coupled, high-spin diiron(III/III) cluster upon treatment of solutions of Fe(II) and MIOX with excess O(2) or H(2)O(2).
Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues.
results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population
Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa (zeige VAPA ELISA Kits) protein.
expression of MIOX is up-regulated by a positive feedback mechanism where xylitol, one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX
myo-inositol oxygenase (MIOX)
MIOX expression/bioactivity was up-regulated under high glucose ambience in LLC-PK1 cells, a tubular cell line.
may play a role in diabetic renal complications
, Myo-inositol oxygenase
, MI oxygenase
, aldehyde reductase (aldose reductase)-like 6
, aldehyde reductase 6, renal
, aldehyde reductase-like 6
, inositol oxygenase
, renal-specific oxido-reducatse
, renal-specific oxidoreductase
, aldehyde reductase (aldose reductase) like 6
, kidney-specific protein 32
, renal-specific oxido-reductase