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study identifies the porcine 2'-5'-oligoadenylate synthetase-like protein (pOASL) as an interferon (zeige IFNA ELISA Kits) (IFN)-stimulated gene (ISG) against classical swine fever virus (CSFV); show that pOASL, as an MDA5 (zeige IFIH1 ELISA Kits)-interacting protein, is a coactivator of MDA5 (zeige IFIH1 ELISA Kits)-mediated IFN induction to exert anti-CSFV actions
we characterized the functional consequences of the Neandertal haplotype in the transcriptional regulation of OAS (zeige SMOC1 ELISA Kits) genes at baseline and infected conditions. We found that cells from people with the Neandertal-like haplotype express lower levels of OAS3 (zeige OAS3 ELISA Kits) upon infection, as well as distinct isoforms of OAS1 (zeige OAS1 ELISA Kits) and OAS2
Suggest 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta (zeige CD247 ELISA Kits) chain down-regulation via caspase-3 (zeige CASP3 ELISA Kits) activation in oral cancer.
Data obtained suggest that the OAS2 rs1293762 and CD209 (zeige CD209 ELISA Kits) rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
Primary mononuclear cells from patients with systemic sclerosis have increased basal levels of OASL (zeige OASL ELISA Kits) and OAS2 genes.
The results suggest that OAS1 (zeige OAS1 ELISA Kits)-OAS3 (zeige OAS3 ELISA Kits)-OAS2 haplotypes are associated with differential susceptibility to clinical outcomes of dengue infection.
The data suggest a possible association between OAS2 and OAS3 (zeige OAS3 ELISA Kits) single nucleotide polymorphisms and the outcome of tick-borne encephalitis virus infection in a Russian population.
2'-5'-oligoadenylate synthetase type 2 (OAS2), a dsRNA binding protein involved in the pathway that activates RNase-L (zeige RNASEL ELISA Kits), is identified as a new binding partner for NOD2 (zeige NOD2 ELISA Kits).
A non-synonymous mutation in Oas2 (I405N) in the viral sensor Oas2 was found and the mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein (zeige CSN1S2A ELISA Kits) synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon (zeige IFNA ELISA Kits) response. The mutation activates the OAS2 pathway.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
, 2'-5' oligoadenylate synthetase-like 1
, 54 kDa 2'-5'-oligoadenylate synthase-like protein 2
, 2'-5'-oligoadenylate synthase-like protein 1
, 59 kDa 2'-5'-oligoadenylate synthase-like protein
, 2'-5' oligoadenylate synthetase-like
, 2'-5' oligoadenylate synthetase-like protein
, 2',5'-oligo adenylate synthetase A
, 2',5'-oligo adenylate synthetase B
, 2'-5'-oligoadenylate synthase-like protein 2
, (2'-5')oligo(A) synthetase 2
, 2'-5'-oligoadenylate synthase 2
, 2-5A synthase 2
, p69 OAS / p71 OAS
, (2-5')oligo(A) synthase 2
, 2',5'-oligoadenylate synthetase-like 11
, 2'-5' oligoadenylate synthetase-like 11
, 2,5-oligoadenylate synthetase-like 11
, 2'-5'-oligoadenylate synthetase 2, 69/71kDa
, 2'-5' oligoadenylate synthetase 2
, 2',5'-oligoadenylate synthetase 2
, 2'-5'-oligoadenylate synthetase 2-like
, 2'-5'-oligoadenylate synthase 2-like