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High Gli2 expression is associated with non-small cell lung cancer.
GLI2 is a dosage-sensitive gene that may be responsible for the agenesis of corpus callosum observed in the proband.
This inhibitory effect on cell growth was partially rescued by exogenous KRT17 (zeige KRT17 ELISA Kits) expression. In the KRT17 (zeige KRT17 ELISA Kits)-positive regions in OSCCs, GLI-1 (zeige GLI1 ELISA Kits) or GLI-2 was frequently detected, and the number of cells with cleaved caspase-3 (zeige CASP3 ELISA Kits) positive was decreased. CONCLUSIONS: KRT17 (zeige KRT17 ELISA Kits) promotes tumor cell growth, at least partially, through its anti-apoptotic effect as a result of the KRT17 (zeige KRT17 ELISA Kits) overexpression by GLIs in OSCC
Data suggest that Nrp1 (neuropilin-1 (zeige NRP1 ELISA Kits)) regulates Hedgehog (zeige SHH ELISA Kits) signaling specifically at the level of activation of GLI2 transcriptional activator function; Nrp1 (zeige NELL1 ELISA Kits) localization to primary cilium does not correlate with Hedgehog (zeige SHH ELISA Kits) signal promotion. These studies were conducted in various cell types.
studies identify a novel molecular mechanism of regulation of CD40L (zeige CD40LG ELISA Kits) by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (zeige CCR3 ELISA Kits) signaling
the data suggest that CCRK (zeige CDK20 ELISA Kits) positively regulates the kinetics by which ciliary proteins such as Smoothened and Gli2 are imported into the cilium, and that the efficiency of ciliary recruitment allows for potent responses to Hedgehog (zeige SHH ELISA Kits) signaling over long time periods.
GLI2 is a regulator of beta-catenin (zeige CTNNB1 ELISA Kits) and provides insights into its role in tumorigenesis.
bioinformatics analysis and luciferase reporter assay predicted the direct binding to miR (zeige MLXIP ELISA Kits)-125b-5p, which has been reported to function as a tumor suppressor in osteosarcoma. Furthermore, functional experiments validated that cir (zeige KCNJ5 ELISA Kits)-GLI2 exerted the tumor-promoting effects on osteosarcoma cells via negatively targeting miR (zeige MLXIP ELISA Kits)-125b-5p.
GANT61, which is a targeted inhibitor of Gli1 (zeige GLI1 ELISA Kits) and Gli2, decreased cell viability and promoted cell apoptosis. Thus, TGF-b1 induced EMT (zeige ITK ELISA Kits) in neuroblastoma (zeige ARHGEF16 ELISA Kits) cells to increase their migration. Specifically, EMT (zeige ITK ELISA Kits) induced by TGF-b1 in neuroblastoma (zeige ARHGEF16 ELISA Kits) cells did not depend on the Smad (zeige SMAD1 ELISA Kits) signaling pathway, and the transcription factor Gli (zeige GLI1 ELISA Kits) participated in TGF-b1-induced EMT (zeige ITK ELISA Kits) independent of Smad (zeige SMAD1 ELISA Kits) signaling.
These results demonstrate that miR (zeige MLXIP ELISA Kits)-124 is an important downstream target gene of Hh signaling, and the Gli2/miR (zeige MLXIP ELISA Kits)-124/AURKA (zeige AURKA ELISA Kits) axis is essential for the proliferation and growth of human glioma cells.
Data indicate that the expression levels of transcription factors Gli1 (zeige GLI1 ELISA Kits) and Gli2 in muscle were the lowest of the 13 tissues.
The 12 SNPs of GLI2 encompassing exon 4 to exon 8 showed strong association with in the anorectal atresia in pigs.
mice with single-allele Gli2 mutations exhibit increased penetrance and severity of Holoprosencephaly in response to low-dose teratogen exposure.
Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse mammary stromal cells to direct a hormone-responsive niche signaling program by activating expression of factors that regulate epithelial stem cells as well as receptors for the mammatrophic hormones estrogen and growth hormone.
Gli2 and Gli3 (zeige GLI3 ELISA Kits) are dephosphorylated and activated in cilia and that impaired Gli2 and Gli3 (zeige GLI3 ELISA Kits) processing in Ta3 (zeige HSP90B1 ELISA Kits) mutant is at least in part due to a decrease in Gli2 and Gli3 (zeige GLI3 ELISA Kits) phosphorylation.
Sufu (zeige SUFUH ELISA Kits) is upregulated in active Shh (zeige SHH ELISA Kits) responding tissues and accompanies Gli (zeige GLI1 ELISA Kits) activators translocating into and Gli (zeige GLI1 ELISA Kits) repressors out of the nucleus.
Gli2+/-;Gli3Delta699/+ mice can serve as a genetic mouse model for common DSD (zeige FADS1 ELISA Kits).
Despite increased production of full-length GLI2 and GLI3 (zeige GLI3 ELISA Kits) isoforms, previously identified GLI (zeige GLI1 ELISA Kits) targets important for mandibular and glossal development (Foxf1 (zeige FOXF1 ELISA Kits), Foxf2 (zeige FOXF2 ELISA Kits), Foxd1 (zeige FOXD1 ELISA Kits) and Foxd2 (zeige FOXD2 ELISA Kits)) were transcriptionally downregulated in Kif3a (zeige KIF3A ELISA Kits)(f/f);Wnt1 (zeige WNT1 ELISA Kits)-Cre embryos.
Gli1 and Gli2 exhibited different functions in the regulation of p63 expression or proliferation of p63(+) cells in Kras-AR driven tumors.
the GLI2 protein level could serve as a feasible marker of ligand-dependent hedgehog (zeige SHH ELISA Kits) activation in pancreatic neoplasms.
Study suggested that loss of Gli2 mRNA mediated the anterior-restricted defect in conditional Dicer (zeige DICER1 ELISA Kits) knockdown mice and showed that miR (zeige MLXIP ELISA Kits)-106b positively regulated Gli2 mRNA expression
This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.
GLI-Kruppel family member GLI2
, glioma-associated oncogene family zinc finger 2
, oncogene GLI2
, tax helper protein 1
, tax helper protein 2
, tax-responsive element-2 holding protein
, tax-responsive element-25-bp sequence binding protein
, zinc finger protein GLI2
, Zn finger transcription factor
, zinc finger protein GLI3
, Tax helper protein