HYOU1 Proteine (HYOU1)

Bezeichnung:
Hypoxia Up Regulated 1 Proteine (HYOU1)
Auf www.antikoerper-online.de finden Sie aktuell 10 Hypoxia Up Regulated 1 (HYOU1) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen HYOU1 Antikörper (111) und HYOU1 Kits (31) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 158 HYOU1 Produkte verfügbar.
Synonyme:
AI415631, Cab140, CBP-140, GRP-170, GRP170, HSP12A, HYOU1, id:ibd5056, ORP-150, ORP150, wu:fd14c05, zgc:56019
alle Proteine anzeigen Gen GeneID UniProt
HYOU1 12282 Q9JKR6
Ratte HYOU1 HYOU1 192235 Q63617
HYOU1 10525 Q9Y4L1

Weitere Synonyme anzeigen

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Am meisten referenzierte HYOU1 Proteine

  1. Human HYOU1 Protein expressed in Human Cells - ABIN2004234 : Ozawa, Kuwabara, Tamatani, Takatsuji, Tsukamoto, Kaneda, Yanagi, Stern, Eguchi, Tsujimoto, Ogawa, Tohyama: 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. in The Journal of biological chemistry 1999 (PubMed)

Weitere Proteine zu HYOU1 Interaktionspartnern

Mouse (Murine) Hypoxia Up Regulated 1 (HYOU1) Interaktionspartner

  1. The relative increase in ORP150 mRNA observed in hypoxia, compared with normoxia, may support its cytoprotective role in oxygendeprived conditions

  2. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.

  3. These results suggest that although ORP150 is protective against bleomycin-induced lung injury, this protein could stimulate bleomycin-induced pulmonary fibrosis by increasing pulmonary levels of TGF-beta1 (zeige TGFB1 Proteine) and myofibroblasts.

  4. Results reveal a previously unrecognized attribute of Grp170 as a superior DNA-binding chaperone capable of amplifying TLR9 (zeige TLR9 Proteine) activation on pathogen recognition.

  5. AICAR (zeige ATIC Proteine) infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis

  6. Secreted grp170 can bind to and co-transport out of tumour cells a full length tumour antigen that may play a role in the anti-tumour immune response.

  7. Grp170 displays multiple peptide binding domains; the presence of two strong peptide binding regions in such a large protein may facilitate the interactions and assembly of two substate proteins.

  8. demonstrated that expression of ORP150 in developing brain most likely serves a cytoprotective function in Purkinje cells

  9. The 150-kDa oxygen-regulated protein may be cytoprotective against ischemia/reperfusion injury via reduction of endoplasmic reticulum stress and probably also inhibition of apoptosis.

  10. ORP150 exerts cytoprotective effects in renal tubular epithelia subjected to I/R injury and suggest a key role for ER stress in the renal tubular response to acute renal failure

Human Hypoxia Up Regulated 1 (HYOU1) Interaktionspartner

  1. Findings establish a general function of Grp170 during ERAD and suggest that positioning this client-release factor at the retrotranslocation site may afford a mechanism to couple client release from BiP (zeige GDF10 Proteine) and retrotranslocation.

  2. Data reveal that Grp170 participates in preparing mutant proinsulin (zeige INS Proteine) for degradation while enabling wild-type proinsulin (zeige INS Proteine) escape from the endoplasmic reticulum.

  3. High ORP150 expression is associated with thyroid cancer.

  4. Two NEFs, Grp170 and Sil1 (zeige SIL1 Proteine), trigger toxin release from BiP (zeige GDF10 Proteine) to enable successful retrotranslocation and clarify the fate of the toxin after it disengages from BiP (zeige GDF10 Proteine).

  5. Grp170 induces nucleotide exchange of BiP (zeige GDF10 Proteine) and releases SV40 virus from BiP (zeige GDF10 Proteine), promoting SV40 ER-to-cytosol transport and infection.

  6. HYOU1 also modulates vIL (zeige VIL1 Proteine)-6's ability to induce CCL2 (zeige CCL2 Proteine).

  7. Here we show that Grp170 can bind directly to a variety of incompletely folded protein substrates in the endoplasmic reticulum, and as expected for a bona fide chaperone, it does not interact with folded secretory proteins.

  8. inducible overexpression of ORP150, in ER stress conditions, exerts inhibitory effect on apoptosis and senescence in human breast carcinoma cells but not in normal fibroblasts

  9. Data indicate that Grp170 (Lhs1 ortholog) coprecipitate with alphaENaC (zeige SCNN1A Proteine).

  10. AICAR (zeige ATIC Proteine) infusion enhanced ORP150 expression, resulting in the marked amelioration of hepatic ER stress and apoptosis

HYOU1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal.

Alternative names and synonyms associated with HYOU1

  • hypoxia up-regulated 1 (HYOU1)
  • hypoxia up-regulated 1 (hyou1)
  • hypoxia up-regulated 1 (Hyou1)
  • AI415631 Protein
  • Cab140 Protein
  • CBP-140 Protein
  • GRP-170 Protein
  • GRP170 Protein
  • HSP12A Protein
  • HYOU1 Protein
  • id:ibd5056 Protein
  • ORP-150 Protein
  • ORP150 Protein
  • wu:fd14c05 Protein
  • zgc:56019 Protein

Bezeichner auf Proteinebene für Hypoxia Up Regulated 1 Proteine (HYOU1)

hypoxia up-regulated 1 , hypoxia up-regulated protein 1 , Hypoxia up-regulated protein 1 , hypoxia up-regulated protein 1-like , 140 kDa Ca(2+)-binding protein , 150-kDa oxygen regulated protein , 170 kDa glucose regulated protein GRP170 , GRP-170 , calcium binding protein 140 , calcium binding protein, 140 kDa , 150 kDa oxygen-regulated protein , ORP-150 , oxygen regulated protein (150kD) , 170 kDa glucose-regulated protein , glucose-regulated protein 170 , glucose regulated protein, 170 kDa , oxygen regulated protein, 150 kDa

GENE ID SPEZIES
508773 Bos taurus
707715 Macaca mulatta
779444 Xenopus (Silurana) tropicalis
100071323 Equus caballus
100173469 Pongo abelii
100380749 Salmo salar
100414434 Callithrix jacchus
100464536 Ailuropoda melanoleuca
12282 Mus musculus
192235 Rattus norvegicus
10525 Homo sapiens
100721624 Cavia porcellus
282295 Bos taurus
100516870 Sus scrofa
428251 Gallus gallus
479410 Canis lupus familiaris
101105848 Ovis aries
398531 Xenopus laevis
327133 Danio rerio
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