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MON1/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-mediated Rab7 activation was indispensable for vacuolar trafficking of tapetum degradation-related cysteine proteases.
Data provide new insight into how disease-associated alterations in Rab7 protein disrupt cellular function in vertebrate sensory neurons. Moreover, findings suggest that defects in axon development may be a previously unrecognized component of Charcot-Marie-Tooth2b disease.
The established transgenic lines ubiquitously express EGFP fusions of Rab5c (zeige Rab5c ELISA Kits) (early endosomes), Rab11a (zeige RAB11A ELISA Kits) (recycling endosomes), and Rab7 (late endosomes) to study localization and dynamics during development.
WDR91 serves as a Rab7 effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
Vps34 (zeige PIK3C3 ELISA Kits) has a previously unknown role in regulating Rab7 activity and late endosomal trafficking.
Rab7 accumulated in GCase (zeige GBA ELISA Kits) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA ELISA Kits) can reverse ALR (zeige GFER ELISA Kits) impairment, we anticipate that strategies to restore GCase (zeige GBA ELISA Kits) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA ELISA Kits) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
The up-regulation of Rab11 (zeige RAB11A ELISA Kits), Rab7, or RILP (zeige RILP ELISA Kits), but not its truncated form RILP (zeige RILP ELISA Kits)-C33 (zeige CD82 ELISA Kits), rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 (zeige RAB11A ELISA Kits) or Rab7 impaired LAMP2A trafficking.
The inhibition of autophagosome-lysosome fusion induced by SapM is dependent on the interaction between SapM and Rab7.
Prion (zeige PRNP ELISA Kits) infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells.
photoreceptor outer segments vesicles engulfed through Lyar-dependent pathway were targeted to phagosomes and colocalized with phagosome marker Rab7
B cell Rab7 mediates induction of activation-induced cytidine deaminase (zeige AICDA ELISA Kits) expression and class-switching in T-dependent and T-independent antibody responses.
CREG1 (zeige CREG1 ELISA Kits) deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1 (zeige CREG1 ELISA Kits)-induced cardiomyocyte autophagy.
Tropheryma whipplei blocks the switch from Rab5 (zeige RAB5A ELISA Kits) to Rab7.
increased endolysosomal iron causes cell death associated with increased cytosolic oxidative stress as well as autophagic impairments, and these effects are subject to modulation by endolysosomal ion channel activity in a RAB7A-dependent manner
WDR91 serves as a Rab7 (zeige RAB7B ELISA Kits) effector that is essential for neuronal development by facilitating endosome conversion in the endosome-lysosome pathway.
The Vici syndrome protein EPG5 is a Rab7 (zeige RAB7B ELISA Kits) effector that determines the fusion specificity of autophagosomes with late endosomes/lysosomes.
up-regulation of RAB7A reported in Alzheimer's disease, could contribute to the extracellular accumulation of pathological TAU
Rab7 (zeige RAB7B ELISA Kits) accumulated in GCase (zeige GBA ELISA Kits) deficient cells, supporting the notion that lysosomal recycling is impaired. Since recombinant GCase (zeige GBA ELISA Kits) can reverse ALR (zeige GFER ELISA Kits) impairment, we anticipate that strategies to restore GCase (zeige GBA ELISA Kits) activity in the brains of both sporadic patients with PD and those with GBA1 (zeige GBA ELISA Kits) mutations will improve autophagy lysosomal pathway, preventing the accumulation of a-synuclein and spread of pathology.
Rab7a depletion decreases the amount of active Rac1 but not its abundance and reduces the number of cells with vimentin (zeige VIM ELISA Kits) filaments facing the wound, indicating that Rab7a has a role in the orientation of vimentin (zeige VIM ELISA Kits) filaments during migration
The study highlighted the importance of a phosphorylation/dephosphorylation switch in controlling timely Rab7 (zeige RAB7B ELISA Kits) localization and activity on endosomes.
show that the maturation of Mtb (zeige NCAPG2 ELISA Kits)-containing autophagosomes into autolysosomes required recruitment of the late endosome marker RAB7 (zeige RAB7B ELISA Kits), forming the intermediate compartment amphisomes
We validated ANKRD13A as a novel constituent of BCR (zeige BCR ELISA Kits) signalosome and showed that BCR (zeige BCR ELISA Kits)-induced phosphorylation of RAB7A at S72 regulates its association with its effector proteins and with endo-lysosomal compartments.
Hepatitis B virus can regulate its own secretion through an activation of the endo-lysosomal and autophagic pathway mediated by Rab7 (zeige RAB7B ELISA Kits) activation.
RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
ras-related protein Rab-7
, ras-related protein Rab-7a
, RAB7A, member RAS oncogene family
, rab7A protein
, ras-related protein rab-7a
, RAB7, member RAS oncogene family
, dystrophin-associated glycoprotein 1
, Ras-associated protein RAB7
, GTP-binding protein (rab7)
, ras-related protein BRL-RAS
, ras-related protein p23