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anti-Human CDC6 Antikörper:
anti-Mouse (Murine) CDC6 Antikörper:
anti-Rat (Rattus) CDC6 Antikörper:
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Human Monoclonal CDC6 Primary Antibody für IP, WB - ABIN268295
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. in Science signaling 2013
PPP2R3B (zeige PPP2R3B Antikörper) codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 (zeige CDT1 Antikörper) interaction
AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR (zeige ANTXR1 Antikörper)-Chk1 (zeige CHEK1 Antikörper) signaling.
The opposing effects of ORC1 (zeige ORC1L Antikörper) (represor) and CDC6 (gene activator) in controlling the level of Cyclin E (zeige CCNE1 Antikörper) ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
Data suggest that regulation of microtubule nucleation and recruitment of pericentriolar proteins to centrosome requires Cdc6 ATPase (zeige DNAH8 Antikörper) activity, as well as centrosomal localization of Cdc6.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (zeige BCL11A Antikörper) cells and can be regulated by BCR/ABL (zeige ABL1 Antikörper) signal transduction through downstream phosphoinositide 3-kinase/Akt (zeige AKT1 Antikörper) and Janus kinase/signal transducer and activator of transcription (zeige STAT1 Antikörper) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (zeige BCL11A Antikörper).
the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (zeige CDK1 Antikörper)) as Cdk1 (zeige CDK1 Antikörper) knockdown increased Cdc6 levels
this study provides a novel regulatory signaling pathway of CDC6-regulated epithelial ovarian cancer growth
The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.
CDC6 and Cyclin F (zeige CCNF Antikörper) interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation.
Cdc6 interacts with centrosomes during mitotic cell division.
CDK1 (zeige CDK1 Antikörper) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (zeige CYCS Antikörper) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog