MLH1 Proteine (MLH1)

Bezeichnung:
MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) Proteine (MLH1)
Auf www.antikoerper-online.de finden Sie aktuell 6 MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MLH1 Antikörper (179) und MLH1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 193 MLH1 Produkte verfügbar.
Synonyme:
1110035C23Rik, AI317206, AI325952, AI561766, CG11482, COCA2, Dmel\\CG11482, dmlh-1, dmlh1, FCC2, hMLH1, HNPCC, HNPCC2, LOC100232198, MLH1, zgc:66301
alle Proteine anzeigen Gen GeneID UniProt
MLH1 17350 Q9JK91
MLH1 4292 P40692
MLH1 81685 P97679

Weitere Synonyme anzeigen

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Weitere Proteine zu MLH1 Interaktionspartnern

Xenopus laevis MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Results suggest that Xenopus MBD4 (zeige MBD4 Proteine)/MLH1 participates in a novel G2 checkpoint that is responsive to DNMT1p levels in developing embryos and cells.

Zebrafish MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Male mlh1 mutants are sterile and display an arrest in spermatogenesis at metaphase I, resulting in increased testis weight due to accumulation of prophase I spermatocytes.

  2. In zebrafish mlh1 mutant (knock-out) males, a delay of both meiotic divisions occurs rather than complete arrest during meiosis I. Eggs fertilized with mutant sperm develop as malformed embryos and are aneuploid.

  3. Identification and characterization of novel knockout mutants of the three major MMR (zeige MRC1 Proteine) genes, mlh1, msh2 (zeige MSH2 Proteine), and msh6 (zeige MSH6 Proteine), in zebrafish that develop tumors at low frequencies.

Mouse (Murine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  2. high mutation ofMlh1(-/-)-deficient fetuses has little effect on the fetuses during their early developmental stages, whereas Mlh1(-/-)-deficient fetuses from X-ray irradiated mothers are clearly effected

  3. radiation exposure could further increase the risk of colorectal carcinogenesis induced by inflammation under the conditions of Mlh1 deficiency.

  4. these data identify Mlh1 and Mlh3 as novel critical genetic modifiers of HTT (zeige HTT Proteine) CAG instability, point to Mlh1 genetic variation as the likely source of the instability difference in B6 and 129 strains

  5. Data indicate that Mlh1 showed only modest methylation was still expressed in both Mlh1(+/-) and Mlh1(+/+) mice.

  6. nickel-smelting fumes upregulated the expression of Mlh1 protein, mouse . This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  7. suggesting a role for the ATPase activity of MLH1 beyond the activation of the endonuclease functions of its MMR (zeige MRC1 Proteine) partner PMS2 (zeige PMS2 Proteine)

  8. Down-regulation of MLH1 is associated with initiation and growth of neuroblastoma (zeige ARHGEF16 Proteine) and brain tumour multicellular spheroids.

  9. MLH1 can convert DNA nicks and point mutations into double-stranded DNA breaks for both core nonhomologous end-joining factors and alternative end-joining pathways of class-switch recombination.

  10. Data show that the constitutive inactivation of MLH1, resulting Mlh1(Deltaex4/Deltaex4) mouse line, displays complete MMR (zeige MRC1 Proteine) deficiency and a cancer predisposition phenotype similar to Mlh1-/- mice.

Human MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. High MLH1 expression is associated with the development of genetic instability and is linked to tumor aggressiveness and early PSA (zeige PLAG1 Proteine) recurrence in prostate cancer.

  2. MLH1 methylation is a frequent molecular event in colorectal cancer and lung cancer patients

  3. Both the mTOR (zeige FRAP1 Proteine)/p-mTOR (zeige FRAP1 Proteine) and BNIP3 (zeige BNIP3 Proteine)/Beclin-1 (zeige BECN1 Proteine) signaling pathways were found to be related to HRS, but only mTOR (zeige FRAP1 Proteine)/p-mTOR (zeige FRAP1 Proteine) is involved in the regulation of HRS via MLH1 and autophagy.

  4. Data suggest that yeast Mlh1-Mlh3 heterodimer does not exhibit hallmarks of a canonical (structure-selective) Holliday junction resolvase/endonuclease; multiple Mlh1-Mlh3 heterodimers appear to load onto DNA to form an activated polymer that cleaves DNA; human MLH1-PMS2 (zeige PMS2 Proteine) exhibits similar characteristics. (MLH = mutL homolog protein; PMS2 (zeige PMS2 Proteine) = post meiotic segregation increased 2 protein)

  5. a causal relationship between MLH1-deficiency and incidence of oncogenic point mutations in tyrosine kinases driving cell transformation and acquired resistance to kinase-targeted cancer therapies, is reported.

  6. Genetic changes between MLH1 and MSH2 (zeige MSH2 Proteine) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (zeige MSH2 Proteine) and DVL3 (zeige DVL3 Proteine) genes (p = 0.034).

  7. Mismatch repair (MMR (zeige MRC1 Proteine))-deficient endometrial carcinomas have significantly increased tumoral and immune stromal PD-L1 (zeige CD274 Proteine) expression relative to MMR (zeige MRC1 Proteine)-intact carcinomas. PD-L1 (zeige CD274 Proteine) is frequently positive in both tumoral and immune cells at the periphery of MMR (zeige MRC1 Proteine)-deficient tumors. Lynch syndrome-associated tumors are more likely to express PDL1 (zeige CD274 Proteine) relative to sporadic MLH1 promoter hypermethylation carcinomas.

  8. These results demonstrate the role of variant rs1800734 in altering transcription factor binding as well as epigenetics at regions beyond the MLH1 CpG island in which it is located.

  9. Results indicate that MLH1-hypermethylated BRAF wild-type colorectal carcinomas can harbor KRAS mutations and arise from precursor polyps resembling conventional tubular/tubulovillous adenomas.

  10. There were a 61.7% (95/154) overexpression of DNMT3B (zeige DNMT3B Proteine), 50.0% (77/154) loss of PTEN expression and 18.2% (28/154) loss of hMLH1 expression in endometrial carcinomas.

Cow (Bovine) MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) Interaktionspartner

  1. Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes.

MLH1 Protein Überblick

Protein Überblick

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

Alternative names and synonyms associated with MLH1

  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1)
  • CG11482 gene product from transcript CG11482-RB (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (LOC100232198)
  • mutL homolog 1 (E. coli) (Mlh1)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (Mlh1)
  • 1110035C23Rik Protein
  • AI317206 Protein
  • AI325952 Protein
  • AI561766 Protein
  • CG11482 Protein
  • COCA2 Protein
  • Dmel\\CG11482 Protein
  • dmlh-1 Protein
  • dmlh1 Protein
  • FCC2 Protein
  • hMLH1 Protein
  • HNPCC Protein
  • HNPCC2 Protein
  • LOC100232198 Protein
  • MLH1 Protein
  • zgc:66301 Protein

Bezeichner auf Proteinebene für MLH1

MutL protein homolog 1 , CG11482-PA , CG11482-PB , Mlh1-PA , Mlh1-PB , DNA mismatch repair protein Mlh1 , mutL-like protein 1 , mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) , DNA mismatch repair protein Mlh1-like , colon cancer, nonpolyposis type 2 , mutL protein homolog 1 , mismatch repair protein 1

GENE ID SPEZIES
420729 Gallus gallus
35796 Drosophila melanogaster
100036779 Xenopus laevis
100337665 Sus scrofa
393632 Danio rerio
588545 Strongylocentrotus purpuratus
747104 Pan troglodytes
100011682 Monodelphis domestica
100050351 Equus caballus
100232198 Taeniopygia guttata
100406787 Callithrix jacchus
100436876 Pongo abelii
100476536 Ailuropoda melanoleuca
100555611 Anolis carolinensis
100593390 Nomascus leucogenys
17350 Mus musculus
4292 Homo sapiens
81685 Rattus norvegicus
477019 Canis lupus familiaris
533652 Bos taurus
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