anti-APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Antikörper

Bezeichnung:
anti-APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Antikörper (APEX1)
Auf www.antikoerper-online.de finden Sie aktuell 192 APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Proteine (33) und APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Kits (17) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 258 APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Produkte verfügbar.
Synonyme:
APE, APE1, APEN, Apex, apex1, apex1a, APX, BAP1, HAP1, hm:zehn1532, MGC76280, MGC78928, MGC79645, Ref-1, REF1, wu:fc13d11, zgc:66204

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Am meisten referenzierte anti-APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Antikörper

  1. Human Monoclonal APEX1 Primary Antibody für ChIP, GS - ABIN4889971 : Fishel, Seo, Smith, Kelley: Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing. in Cancer research 2003 (PubMed)
    Zeige alle 77 Referenzen für 4889971

  2. Human Polyclonal APEX1 Primary Antibody für IHC (p), IHC - ABIN257862 : Demple, Herman, Chen: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Zeige alle 4 Referenzen für 257862

  3. Human Polyclonal APEX1 Primary Antibody für EIA, IF - ABIN358027 : Li, Zhang, Ma, Zhang, Li, Pan, You: Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population. in Carcinogenesis 2009 (PubMed)
    Zeige alle 4 Referenzen für 358027

  4. Human Polyclonal APEX1 Primary Antibody für IF, WB - ABIN389367 : Vascotto, Fantini, Romanello, Cesaratto, Deganuto, Leonardi, Radicella, Kelley, DAmbrosio, Scaloni, Quadrifoglio, Tell: APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. in Molecular and cellular biology 2009 (PubMed)
    Zeige alle 3 Referenzen für 389367

  5. Cow (Bovine) Polyclonal APEX1 Primary Antibody für WB - ABIN2779917 : Izumi, Brown, Naidu, Bhakat, Macinnes, Saito, Chen, Mitra: Two essential but distinct functions of the mammalian abasic endonuclease. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)

  6. Cow (Bovine) Polyclonal APEX1 Primary Antibody für IHC, WB - ABIN2779778 : Ding, OHara, Denning, Dirden-Kramer, Mifflin, Reyes, Ryan, Elliott, Izumi, Boldogh, Mitra, Ernst, Crowe: Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. in Gastroenterology 2004 (PubMed)

Weitere Antikörper gegen APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Interaktionspartner

Human APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. These results suggest that degradation of endogenous APE1 by Parkin (zeige PARK2 Antikörper) occur when cells are stressed to activate Parkin (zeige PARK2 Antikörper), and imply a role of Parkin (zeige PARK2 Antikörper) in maintaining the quality of APE1, and loss of Parkin (zeige PARK2 Antikörper) may contribute to elevated APE1 levels in glioblastoma.

  2. The efficiency of AP site cleavage by APE1 was affected by the benzo[a]pyrenyl-DNA adduct (BPDE-dG) in the opposite strand.

  3. This study supported the hypothesis that the APE1 rs1760944 T>G polymorphism may be associated with N,N-dimethylformamide -induced abnormal liver function in the Chinese Han population.

  4. Repair of the uracil adjacent to cisplatin ICLs proceeds through the classical BER pathway, highlighting the importance of specific proteins in this redundant pathway. Removal of uracil is followed by the generation of an abasic site and subsequent cleavage by AP endonuclease 1 (APE1). Inhibition of either the repair or redox domain of APE1 gives rise to cisplatin resistance.

  5. Overexpressed APE1 promotes ovarian cancer growth and metastasis. Downregulated APE1 could suppress cell activity via AP-1 (zeige FOSB Antikörper) pathway, suggesting that APE1 gene may be a potential therapeutic target for ovarian cancer.

  6. Our results indicate that the tumor-associated APE1 R237C variant is a possible susceptibility factor, but not likely a driver of cancer cell phenotypes.

  7. Association of the APE1 single nucleotide polymorphism rs3136820 and the levels of abasic sites in human leukocytes derived from breast cancer patients

  8. APE1 acetylation is an integral part of the base excision repair pathway for maintaining genomic integrity.

  9. Effects of monovalent (K(+)) and divalent (Mg(2 (zeige MUC7 Antikörper)+), Mn(2+), Ca(2 (zeige CA2 Antikörper)+), Zn(2+), Cu(2+), and Ni(2 (zeige VMP1 Antikörper)+)) metal ions on DNA binding and catalytic stages of APEX1 were studied.

  10. APE1 Accelerates turnover of OGG1 (zeige OGG1 Antikörper) by preventing retrograde binding to the abasic-site product.

Pig (Porcine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. Study shows the methylation of the APE1 promoter and its role in mediating the functional effects of redox reactions induced by oxidative stress.

Cow (Bovine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. Meiosis progression and female age affect expression profile of DNA repair APEX1 gene in bovine oocytes.

  2. prediction of the 3D structure of bovine AP lyase (BAP1); models of mutants showed substitution of Arg176-->Ala leads to the loss of DNA binding whereas mutation of Asp282-->Ala and His308-->Asn leads to a decrease in the enzymatic activity.

Mouse (Murine) APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Interaktionspartner

  1. findings provide evidence that endogenous APE1 protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury

  2. Suppression of Ape1/Ref-1 redox function leads to an increased cell surface retention of IL-12 (zeige IL12A Antikörper) and enhances Th1 (zeige HAND1 Antikörper) responses.

  3. Is closely associated with upregulation of the Ref1 (zeige THOC4 Antikörper)/Nrf2 (zeige NFE2L2 Antikörper) signalling pathway.

  4. Results show the stimulatory effect of PARP-1 (zeige PARP1 Antikörper) on APE1-dependent base excision repair (BER). PARP-1 (zeige PARP1 Antikörper) and APE1 appear to have a functional interaction in BER since PARP-1 (zeige PARP1 Antikörper) can stimulate the strand incision activity of APE1.

  5. increases in APEX1 level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  6. Endothelial cell tumor proliferation was found to be dependent on Apex-1 expression.

  7. Expression of OGG1 (zeige OGG1 Antikörper) and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  8. Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR (zeige SCARA3 Antikörper)).

  9. These results suggest that mitochondrial APE1/Ref-1 is contributed to the protective role to protein kinase C (zeige PKC Antikörper)-induced mitochondrial dysfunction in endothelial cells.

  10. Spinal motor neurones down-regulate APE1 upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1) Antigen-Profil

Beschreibung des Gens

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene\; all encode the same protein.

Alternative names and synonyms associated with APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 (APEX1)

  • APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1) Antikörper
  • DNA-apurinic or apyrimidinic site lyase (apex1) Antikörper
  • APEX nuclease (multifunctional DNA repair enzyme) 1 (apex1) Antikörper
  • DNA-(apurinic or apyrimidinic site) lyase (CNG03640) Antikörper
  • DNA-(apurinic or apyrimidinic site) lyase (CNH01280) Antikörper
  • DNA-(apurinic or apyrimidinic site) lyase (nth) Antikörper
  • DNA-(apurinic or apyrimidinic site) lyase (Spirs_4119) Antikörper
  • DNA-(apurinic or apyrimidinic site) lyase (Palpr_0103) Antikörper
  • APEX nuclease (multifunctional DNA repair enzyme) 1 (Apex1) Antikörper
  • apurinic/apyrimidinic endonuclease 1 (Apex1) Antikörper
  • APE Antikörper
  • APE1 Antikörper
  • APEN Antikörper
  • Apex Antikörper
  • apex1 Antikörper
  • apex1a Antikörper
  • APX Antikörper
  • BAP1 Antikörper
  • HAP1 Antikörper
  • hm:zehn1532 Antikörper
  • MGC76280 Antikörper
  • MGC78928 Antikörper
  • MGC79645 Antikörper
  • Ref-1 Antikörper
  • REF1 Antikörper
  • wu:fc13d11 Antikörper
  • zgc:66204 Antikörper

Bezeichner auf Proteinebene für APEX1

DNA-(apurinic or apyrimidinic site) lyase , APEX nuclease 1 , APEX nuclease (multifunctional DNA repair enzyme) 1 , AP endonuclease class I , AP lyase , apurinic-apyrimidinic endonuclease 1 , apurinic/apyrimidinic (abasic) endonuclease , deoxyribonuclease (apurinic or apyrimidinic) , protein REF-1 , redox factor-1 , AP endonuclease 1 , APEN , apurinic/apyrimidinic endonuclease 1 , apurinic/apyrimidinic endonuclease , zap1 , Apurinic-apyrimidinic endonuclease 1 , Redox factor-1 , APEX nuclease

GENE ID SPEZIES
100431102 Gallus gallus
100196733 Salmo salar
394929 Xenopus (Silurana) tropicalis
432324 Xenopus laevis
3258636 Cryptococcus neoformans var. neoformans JEC21
3259293 Cryptococcus neoformans var. neoformans JEC21
4211673 Alcanivorax borkumensis SK2
9492248 Spirochaeta smaragdinae DSM 11293
9997717 Paludibacter propionicigenes WB4
328 Homo sapiens
79116 Rattus norvegicus
482558 Canis lupus familiaris
100154728 Sus scrofa
281630 Bos taurus
406730 Danio rerio
100987860 Pan paniscus
465200 Pan troglodytes
11792 Mus musculus
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