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CpG and methylation-dependent DNA binding and dynamics of the MBD2 (zeige DPEP2 Proteine) protein at the single-molecule level have been reported.
Results show that MBD2 (zeige DPEP2 Proteine) mediates epigenetic silencing of Htra1 (zeige HTRA1 Proteine).
MBD2 (zeige DPEP2 Proteine) has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
MBD2 (zeige DPEP2 Proteine) expression was elevated in HCC (zeige FAM126A Proteine) tissue, which suggesting MBD2 (zeige DPEP2 Proteine) as a candidate prognostic marker of HCC (zeige FAM126A Proteine).
downregulation of miR (zeige MLXIP Proteine)-221 inhibits cell migration and invasion at least partially through targeting MBD2 (zeige DPEP2 Proteine) in the human OSCC cell line UM1.
Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD (zeige DPEP1 Proteine) domain and MBD2 (zeige DPEP2 Proteine) C-terminus.
MBD2 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
The dynamics of MBD2 (zeige DPEP2 Proteine) deposition across methylated DNA regions was associated with the oncogenic transformation of human mammary cells.
Data suggest that MBD2 (zeige DPEP2 Proteine) binds primarily at highly methylated regions, with a strong preference for CpG islands and highlights that MBD2 (zeige DPEP2 Proteine) binding sites display increased methylation in primary breast cancer tissues as compared to normal mammary cells.
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 (zeige DPEP2 Proteine) for methylated DNA.
It has been shown that chromatin localization of Mbd2 and Mbd3 (zeige MBD3 Proteine) is highly overlapping, and both proteins are interdependent for chromatin association.
MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions.
Loss of Mbd2 resulted in impaired implementation of above DNA methylation (zeige HELLS Proteine) changes associated with altered energy homeostasis, which then protected mice from HFD-induced obesity and insulin (zeige INS Proteine) resistance.
Mbd2 has a key role regulating expression of a range of genes that are associated with optimal dendritic cell activation and function.
methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx (zeige HLX Proteine).
Biophysical analyses show that the MBD2IDR is an intrinsically disordered region (IDR). However, despite this inherent disorder, MBD2IDR increases the overall binding affinity of MBD2 for methylated DNA.
miR (zeige MLXIP Proteine)-290/371-Mbd2-Myc (zeige MYC Proteine) circuit regulates glycolytic metabolism to promote pluripotency.
these findings suggest that CpG methylation and MBD2 are involved in altering Scn3a (zeige SCN3A Proteine) expression during postnatal development and seizure condition.
Data suggest that methyl-CpG binding domain protein 2 (MBD2) gene knockout may lead to accumulation of more deposits on the Bruch's membrane (BM) and influence the pathogenesis of age-related macular degeneration (AMD (zeige AMD1 Proteine)).
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
methyl-CpG binding domain protein 2
, methyl-CpG-binding domain protein 2
, methyl-CpG-binding protein MBD2
, methyl-CpG binding protein MBD2