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anti-Neurofibromin 2 (NF2) Antikörper

Bezeichnung:
anti-Neurofibromin 2 Antikörper (NF2)
Auf www.antikoerper-online.de finden Sie aktuell 162 Neurofibromin 2 (NF2) Antikörper von 24 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Neurofibromin 2 Kits (14) und Neurofibromin 2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 195 Neurofibromin 2 Produkte verfügbar.
Synonyme:
ACN, BANF, merlin, NF2, NF2a, SCH, zgc:194620, zgc:194631

Meistgesuchte Reaktivitäten zu anti-Neurofibromin 2 (NF2) Antikörper

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Am meisten referenzierte anti-Neurofibromin 2 Antikörper

  1. Human Polyclonal NF2 Primary Antibody für IHC (p), WB - ABIN197520 : Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. in Molecular and cellular biology 2005 (PubMed)
    Zeige alle 4 Referenzen für ABIN197520

  2. Human Polyclonal NF2 Primary Antibody für IF, WB - ABIN197028 : Yang, Hinds: Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. in Cancer research 2006 (PubMed)
    Zeige alle 4 Referenzen für ABIN197028

  3. Human Polyclonal NF2 Primary Antibody für IHC, ELISA - ABIN1532019 : Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. in PLoS ONE 2012 (PubMed)
    Zeige alle 3 Referenzen für ABIN1532019

  4. Human Polyclonal NF2 Primary Antibody für EIA, WB - ABIN117953 : Gutmann, Wright, Geist, Snider: Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. in Human molecular genetics 1995 (PubMed)
    Zeige alle 2 Referenzen für ABIN117953

  5. Human Polyclonal NF2 Primary Antibody für IP, IHC - ABIN104130 : Wang, Lu, Tang, Wang, Wu: The phosphorylation status of merlin in sporadic vestibular Schwannomas. in Molecular and cellular biochemistry 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN104130

  6. Human Polyclonal NF2 Primary Antibody für ELISA, WB - ABIN1533058 : Trofatter, MacCollin, Rutter, Murrell, Duyao, Parry, Eldridge, Kley, Menon, Pulaski: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. in Cell 1993 (PubMed)
    Zeige alle 2 Referenzen für ABIN1533058

  7. Zebrafish (Danio rerio) Polyclonal NF2 Primary Antibody für EIA, IHC (p) - ABIN401528 : Sadler, Amsterdam, Soroka, Boyer, Hopkins: A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. in Development (Cambridge, England) 2005 (PubMed)

  8. Human Polyclonal NF2 Primary Antibody für EIA, WB - ABIN453191 : James, Han, Polizzano, Plotkin, Manning, Stemmer-Rachamimov, Gusella, Ramesh: NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. in Molecular and cellular biology 2009 (PubMed)

Weitere Antikörper gegen Neurofibromin 2 Interaktionspartner

Zebrafish Neurofibromin 2 (NF2) Interaktionspartner

  1. Mutation of nf2 gene develops extrahepatic choledochal cysts in the common bile duct

Mouse (Murine) Neurofibromin 2 (NF2) Interaktionspartner

  1. co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (zeige YAP1 Antikörper).

  2. Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP (zeige YAP1 Antikörper) signaling activity.

  3. NF2 is activated by oxidative stress in cardiomyocytes and myocardium and facilitates apoptosis.

  4. loss of axonal contact following nerve injury results in merlin phosphorylation leading to increased p75(NTR (zeige NGFR Antikörper)) expression.

  5. Loss of Nf2 and Cdkn2a (zeige CDKN2A Antikörper)/b have synergistic effects with PDGF-B (zeige PDGFB Antikörper) overexpression promoting meningioma malignant transformation.

  6. Merlin 1 and 2 act as tumor suppressors and are required for optimal sperm maturation

  7. Together our results uncover miRNAs as yet another negative mechanism controlling Merlin tumor suppressor functions.

  8. Merlin and Ezrin (zeige EZR Antikörper) are components of a mechanism where mechanical forces associated with cell junctions are transduced across the cell cortex via cortical actomyosin cytoskeleton to control lateral mobility and activity of epidermal growth factor receptor (zeige EGFR Antikörper).

  9. The study describe a novel NF2 mouse model recapitulating schwannoma phenotypes found in human patients where tumors develop in the cranial nerve VIII (zeige COX8A Antikörper) and/or the spinal roots.

  10. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2 (zeige ERBB2 Antikörper)-dependent manner.

Human Neurofibromin 2 (NF2) Interaktionspartner

  1. co-deletion of Rac1 with Nf2 blocks tumor initiation but paradoxically exacerbates hepatomegaly induced by Nf2 loss, which can be suppressed either by treatment with pro-oxidants or by co-deletion of Yap (zeige YAP1 Antikörper).

  2. Data suggest that, at least using the commercial antibodies used in this study, immunohistochemical staining for NF2 (neurofibromin 2), LATS2 (zeige LATS2 Antikörper) (large tumor suppressor (zeige LATS1 Antikörper) kinase 2), and YAP (zeige YAP1 Antikörper)/TAZ (zeige TAZ Antikörper) (nuclear translocation of complex of Yes-associated protein [YAP (zeige YAP1 Antikörper)] with transcriptional coactivator with PDZ-binding motif (zeige WWTR1 Antikörper) [TAZ (zeige TAZ Antikörper)]) is not helpful for differential diagnosis of mesothelioma versus a benign proliferation.

  3. The mortality of patients with NF2 diagnosed in more recent decades was lower than that of patients diagnosed earlier.

  4. AMOTL1 (zeige AMOTL1 Antikörper) Promotes Breast Cancer Progression and Is Antagonized by Merlin

  5. homozygous deletions in CDKN2A (zeige CDKN2A Antikörper) and hemizygous loss of NF2 as detected by fluorescence in situ hybridization would confer a poor clinical outcome and may guide future treatment decisions for patients with peritoneal mesothelioma.

  6. NF2/merlin inactivation augments mutant RAS signaling by promoting YAP (zeige YAP1 Antikörper)/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK (zeige MAPK1 Antikörper) output and increased sensitivity to MEK (zeige MAP2K1 Antikörper) inhibitors.

  7. Loss of Nf2 and Cdkn2a (zeige CDKN2A Antikörper)/b have synergistic effects with PDGF-B (zeige PDGFB Antikörper) overexpression promoting meningioma malignant transformation.

  8. we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP (zeige YAP1 Antikörper)-dependent induction of CYR61/CCN1 (zeige CYR61 Antikörper) and miR (zeige MLXIP Antikörper)-296-3p.

  9. angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling

  10. (Delta2-4)Merlin variant disrupts the normal function of Merlin and promotes hepatocellular carcinoma metastasis.

Neurofibromin 2 (NF2) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development\; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.

Alternative names and synonyms associated with Neurofibromin 2 (NF2)

  • neurofibromin 2b (merlin) (nf2b) Antikörper
  • neurofibromin 2 (bilateral acoustic neuroma) (NF2) Antikörper
  • neurofibromin 2 (merlin) (NF2) Antikörper
  • neurofibromin 2 (NF2) Antikörper
  • neurofibromin 2 (LOC100357691) Antikörper
  • merlin-like (LOC417537) Antikörper
  • neurofibromatosis 2 (Nf2) Antikörper
  • neurofibromin 2 (merlin) (Nf2) Antikörper
  • neurofibromin 2a (merlin) (nf2a) Antikörper
  • ACN Antikörper
  • BANF Antikörper
  • merlin Antikörper
  • NF2 Antikörper
  • NF2a Antikörper
  • SCH Antikörper
  • zgc:194620 Antikörper
  • zgc:194631 Antikörper

Bezeichner auf Proteinebene für anti-Neurofibromin 2 (NF2) Antikörper

neurofibromin 2 (bilateral acoustic neuroma) , merlin , neurofibromatosis 2 , neurofibromin 2 , moesin-ezrin-radixin-like protein , neurofibromin-2 , schwannomin , moesin-ezrin-radixin like , moesin-ezrin-radizin-like protein , schwannomerlin

GENE ID SPEZIES
405887 Danio rerio
395158 Gallus gallus
100058977 Equus caballus
100329097 Saccoglossus kowalevskii
100357691 Oryctolagus cuniculus
417537 Gallus gallus
18016 Mus musculus
4771 Homo sapiens
25744 Rattus norvegicus
477535 Canis lupus familiaris
100520699 Sus scrofa
540479 Bos taurus
561184 Danio rerio
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