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Merlin Antikörper (pSer518)

NF2 Reaktivität: Human WB, ELISA, IHC, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN104130
  • Target Alle Merlin (NF2) Antikörper anzeigen
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Bindungsspezifität
    • 27
    • 15
    • 9
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer518
    Reaktivität
    • 76
    • 65
    • 53
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 87
    • 4
    • 1
    Kaninchen
    Klonalität
    • 89
    • 3
    Polyklonal
    Konjugat
    • 46
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Merlin Antikörper ist unkonjugiert
    Applikation
    • 70
    • 29
    • 27
    • 26
    • 18
    • 17
    • 11
    • 10
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Sterilität
    Sterile filtered
    Immunogen
    Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).
    Isotyp
    IgG
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  • Applikationshinweise
    This phospho-specific polyclonal antibody was tested by immunoblotting and ELISA.  By ELISA, the antibody was found to be reactive with the phosphorylated form of the immunizing peptide and minimally reactive with the non-phosphorylated form of the immunizing peptide.   Immunoblotting will detect human and mouse NF2 (Merlin).  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Hu, Du, Shelton, Oldham, DiPersio, Klein: "An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice." in: Cell stem cell, Vol. 21, Issue 1, pp. 91-106.e6, (2018) (PubMed).

    Angelo, Wu, Meng, Sun, Kopetz, McCutcheon, Slopis, Kurzrock: "Combining Curcumin (Diferuloylmethane) and Heat Shock Protein Inhibition for Neurofibromatosis 2 Treatment: Analysis of Response and Resistance Pathways." in: Molecular cancer therapeutics, (2011) (PubMed).

    Lallemand, Saint-Amaux, Giovannini: "Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells." in: Journal of cell science, Vol. 122, Issue Pt 22, pp. 4141-9, (2010) (PubMed).

    Wang, Lu, Tang, Wang, Wu: "The phosphorylation status of merlin in sporadic vestibular Schwannomas." in: Molecular and cellular biochemistry, Vol. 324, Issue 1-2, pp. 201-6, (2009) (PubMed).

  • Target
    Merlin (NF2) (Neurofibromin 2 (NF2))
    Andere Bezeichnung
    NF2 (NF2 Produkte)
    Synonyme
    ACN antikoerper, BANF antikoerper, SCH antikoerper, NF2 antikoerper, merlin antikoerper, zgc:194620 antikoerper, zgc:194631 antikoerper, NF2a antikoerper, nf2 antikoerper, neurofibromin 2 antikoerper, neurofibromin 2a (merlin) antikoerper, neurofibromin 2b (merlin) antikoerper, neurofibromin 2 (merlin) S homeolog antikoerper, NF2 antikoerper, Nf2 antikoerper, nf2a antikoerper, nf2b antikoerper, nf2.S antikoerper
    Hintergrund
    The recently isolated neurofibromatosis 2 tumor suppressor gene encodes a 595 amino acid protein (Merlin).  The protein product Merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumor suppressor whose absence results in the occurrence of multiple tumors of the nervous system, particularly schwannomas and meningiomas. Merlin's similarity to ERM’s suggests that it might share functions, acting as a link between cytoskeletal components and the cell membrane.  The NF2 protein is highly expressed in human fibroblasts and is detected as a single band of about 75kDa.  This antibody is specific for the phosphorylated form of human NF2 (Merlin).
    Synonyms: ACN antibody, BANF antibody, SCH, bilateral acoustic neuroma antibody, moesin ezrin radixin like protein antibody, Moesin ezrin radizin like protein antibody, Neurofibromatosis 2 antibody
    Gen-ID
    4771
    NCBI Accession
    NP_000259
    UniProt
    P35240
    Pathways
    Cell-Cell Junction Organization
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