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Angiogenic activity in the atherosclerotic plaques coincides with alphavbeta3-integrin by the adventitial vasa (zeige DDX4 ELISA Kits) vasorum and intraplaque neovascularization.
Tat (zeige TAT ELISA Kits) PTD (zeige ETS2 ELISA Kits)-Endostatin (zeige COL18A1 ELISA Kits)-RGD showed high penetration ability through ocular barriers, bound specifically to integrin alpha5beta3 and effectively inhibited the abnormal angiogenesis. Tat (zeige TAT ELISA Kits) PTD (zeige ETS2 ELISA Kits)-Endostatin (zeige COL18A1 ELISA Kits)-RGD represents a potent novel drug applied via eye drops for fundus oculi neovascularization diseases.
The synergy of circulating factor suPAR and APOL1 (zeige APOL1 ELISA Kits) G1 or G2 on alphavbeta3 integrin activation is a mechanism for CKD.
Suggest that alphavbeta3 integrin plays an important role in coordinating hepatocyte division during liver regeneration after partial hepatectomy via crosstalk with fibrin ECM (zeige MMRN1 ELISA Kits).
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta (zeige TGFB1 ELISA Kits).
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
These data support the hypothesis that IL-1beta (zeige IL1B ELISA Kits) was initially induced by hyperoxia; alphavbeta6 subsequently interacted with and activated TGF-beta1 (zeige TGFB1 ELISA Kits).
Gdf-5 (zeige GDF5 ELISA Kits) induced the expression of the alpha5 sub-unit, while Bmp-7 (zeige BMP7 ELISA Kits) induced the expression of the alphaV sub-unit.
These results suggest that phloretin was an inhibitor of actin podosomes and sealing zone, disrupting alpha5beta3 integrin-c-Src-Pyk2/Syk signaling pathway for the regulation of actin cytoskeletal organization in osteoclasts.
TN-C (zeige TNC ELISA Kits) may enhance inflammatory responses by accelerating macrophage migration and synthesis of proinflammatory/profibrotic cytokines via integrin alphaVbeta3/FAK (zeige PTK2 ELISA Kits)-Src (zeige SRC ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits), resulting in increased fibrosis.
Data show that sulfatide promoted integrin alphaV(ITGAV) expression and stimulated integrin alphaVbeta3 clustering and signaling in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) cells.
Low integrin alphaVbeta3 expression is associated with glioblastoma.
Data show that FGF2 (zeige FGF2 ELISA Kits) mutants have potential as anti-angiogenic agents and useful tools for studying the role of integrin alphavbeta3 in FGF2 (zeige FGF2 ELISA Kits) signalling.
VANGL2 interacts with Integrin alphaVbeta3 to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.
The results indicate that shear stress is an important mediator in endothelial progenitor cells expression of CD59 regulated by the extacellular matrix-integrin alphaVbeta3-F-actin pathway, which is a key factor in preventing membrane attack complex-mediated cell autolysis.
The mechanism of resistance of tongue squamous carcinoma cells Cal27 with de novo integrin alphavbeta3 expression to anticancer drugs was studied. In Cal27 cells integrin alphav heterodimers signal through pSrc(Y418) while this is not the case in integrin alphavbeta3-expressing cells.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (zeige IGF1R ELISA Kits).
data demonstrate that M. tuberculosis stimulation upregulates integrin alphaVbeta3 expression on monocytes, which upregulates secretion of MMP-1 (zeige MMP1 ELISA Kits) and -10 on adhesion to the extracellular matrix; this leads to increased monocyte recruitment and collagenase activity, which will drive inflammatory tissue damage
overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail
The observed effects of shear stress on integrin alpha(v)beta(3) and p38 MAPK (zeige MAPK14 ELISA Kits) activation, as well as on FGF-2 (zeige FGF2 ELISA Kits) release could be mimicked by application of pancreatic elastase to static endothelial cells.
Inhibition of integrin alphavbeta3 prevents urokinase plasminogen (zeige PLG ELISA Kits) activator-mediated impairment of cerebrovasodilation after cerebral hypoxia/ischemia.
Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.
specific substitutions show that the stable binding between foot-and-mouth disease virus VP1 and integrin alphavbeta6 is dependent on a helical structure and, specifically, two leucine residues at positions +1 and RGD +4 from the RGD motif.
These results demonstrate the critical role of the RhoA (zeige RHOA ELISA Kits)/alphavbeta5 integrin pathway in mediating Pseudomonas aeruginosa-induced lung vascular permeability.
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8\; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands\; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Alternative splicing results in multiple transcript variants.
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
, alphav integrin
, integrin alpha V
, integrin alpha-V
, vitronectin receptor alpha polypeptide (VNRA)
, vitronectin receptor subunit alpha
, antigen identified by monoclonal antibody L230
, integrin alphaVbeta3
, Dnmt3l-ps1 pseudogene
, alphaV integrin
, integrin alpha v
, vitronectin receptor alpha subunit
, integrin alpha V subunit