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P2Y (zeige P2RY1 Antikörper)(11) is transcribed during embryonic development, beginning at gastrulation, and is enriched in the developing nervous system.
Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy.
Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells.
Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 (zeige PANX1 Antikörper) channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair.
the physiological impact of A87T mutation of the P2Y11 receptor derives from detrimental effects on P2Y1 (zeige P2RY1 Antikörper)-P2Y11 receptor interaction.
vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages
P2Y11 receptor mediates interferon gamma (zeige IFNG Antikörper)-induced IL-6 (zeige IL6 Antikörper) production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma (zeige IFNG Antikörper) induced skin inflammatory conditions
P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers.
The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B (zeige CPT1B Antikörper)/CHKB (zeige CHKB Antikörper) (rs5770917) in the Chinese population.
Extracellular NAD stimulates mesenchymal stem cell functions through activation of P2Y11 receptor.
Common variants in P2RY11 are associated with narcolepsy.
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
G-protein coupled receptor
, P2Y purinoceptor 11-like
, P2Y purinoceptor 11
, purinergic receptor P2Y11