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Human Beclin 1 ELISA Kit für Sandwich ELISA - ABIN649148
Emanuele, Minoretti, Sanchis-Gomar, Pareja-Galeano, Yilmaz, Garatachea, Lucia: Can enhanced autophagy be associated with human longevity? Serum levels of the autophagy biomarker beclin-1 are increased in healthy centenarians. in Rejuvenation research 2014
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Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity.
beta-asarone changed the cellular morphology, inhibited cell proliferation, and enhanced the expression of P53 (zeige TP53 ELISA Kits), LC3 (zeige MAP1LC3A ELISA Kits)-II/I, Beclin-1, AMPK (zeige PRKAA1 ELISA Kits), and pAMPK while inhibiting the expression of P62 (zeige GTF2H1 ELISA Kits), Bcl-2 (zeige BCL2 ELISA Kits), mTOR (zeige FRAP1 ELISA Kits), and pmTOR in glioma cells.
PINK1 silencing impaired BECN1 enrichment at mitochondria-associated membranes independently of PARK2, suggesting a novel role for PINK1 in regulating mitophagy.
ABHD5 (zeige ABHD5 ELISA Kits) possesses a PNPLA2 (zeige PNPLA2 ELISA Kits)-independent function in regulating autophagy and tumorigenesis.
BECN1-APP (zeige APP ELISA Kits) association and BECN1-dependent APP (zeige APP ELISA Kits) endocytosis and degradative trafficking were negatively regulated by active AKT (zeige AKT1 ELISA Kits).
findings will also clarify the conflict between apoptosis-autophagy on the basis of its unique property derived from surface chemistry modulation, in context of Beclin-1 eminent cleavage/splice which remarks novel effect of Beclin-1 dependent tuning of autophagosomes formation and switch to enhance apoptotic index, mediates by PI3KC3 cleavage and caspase (zeige CASP3 ELISA Kits) activation
Data suggest that BECN1 exhibits a helical region that transitions between packing (folding/unfolding) as part of either one of two conserved domains; packing of this helical region appears to have important implications for relative stability of autophagy-inactive and autophagy-active BECN1 complexes.
downregulation of HOXC9 (zeige HOXC9 ELISA Kits) releases its transcriptional inhibition of DAPK1 (zeige DAPK1 ELISA Kits), resulting in the activation of the DAPK1 (zeige DAPK1 ELISA Kits)-Beclin1 pathway, which induces autophagy in glioblastoma cells
ASPP2 (zeige TP53BP2 ELISA Kits) is a key regulator of BECN1-dependent autophagy.
the polyQ domain enables wild-type ataxin 3 (zeige ATXN3 ELISA Kits) to interact with beclin 1, a key initiator of autophagy; this interaction allows the deubiquitinase activity of ataxin 3 (zeige ATXN3 ELISA Kits) to protect beclin 1 from proteasome-mediated degradation and thereby enables autophagy
findings suggest that expression of cFLIPL regulates the basal interaction of Bcl-2 (zeige BCL2 ELISA Kits) with Beclin-1 and substantiates p53 (zeige TP53 ELISA Kits) dependent ubiquitination of Beclin-1 during autophagic stress to determine the fate of cell death or survival.
BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2 (zeige CASP2 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits)-AKT (zeige AKT1 ELISA Kits)-MTOR (zeige FRAP1 ELISA Kits) and CASP2 (zeige CASP2 ELISA Kits)-AMPK (zeige PRKAA1 ELISA Kits)-MAPK (zeige MAPK1 ELISA Kits) by decreasing CASP2 (zeige CASP2 ELISA Kits).
proteostasis regulator cysteamine, which rescues the function of the most common F508del-CFTR (zeige CFTR ELISA Kits) mutant and hence reduces lung inflammation in CF patients, can also repair the defects of CF macrophages, thus restoring both bacterial internalization and clearance through a process that involves upregulation of the pro-autophagic protein Beclin 1 and re-establishment of the autophagic pathway.
Genetically disrupting BECN1-BCL2 (zeige BCL2 ELISA Kits) binding hyperactivates autophagy in vivo, which sequestrates amyloid oligomers and prevents Alzheimer's disease progression.
Data show that 1-month of oral treatment with beta-asarone reduces AChE, Abeta42, APP (zeige APP ELISA Kits) and Beclin-1 levels and alleviates some behavioral impairments by inhibiting the autophagy via regulating the PI3K/Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) pathway in APP (zeige APP ELISA Kits)/PS1 (zeige PSEN1 ELISA Kits) transgenic mice. The results further support the exploration of beta-asarone as a possible disease-modifying agent for the treatment of Alzheimer's disease.
identify FAK (zeige PTK2 ELISA Kits) as a novel negative regulator of Beclin1-mediated autophagy and indicate that this pathway can facilitate the promotion of compensatory hypertrophic growth
The results not only demonstrate that BECN1 as a PI3K-III component is essential for cytokinesis, but also suggest that BECN1 is not associated with autophagy pathway in mouse oocytes.
this study shows that knockdown of beclin1 enhances macrophage-associated (zeige CD163 ELISA Kits) phagocytosis and intracellular killing of Pseudomonas aeruginosa
provide the novel evidence that GADD45A (zeige GADD45A ELISA Kits) inhibits autophagy via impairing the BECN1-PIK3C3 (zeige PIK3C3 ELISA Kits) complex formation
in-vitro genetic depletion of beclin-1 in high glucose treated adult rat cardiomyocytes markedly inhibited the level of autophagy and subsequent apoptotic cell death.
suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A ELISA Kits), B and autophagy-associated genes (ATG5 (zeige ATG5 ELISA Kits), mTOR (zeige FRAP1 ELISA Kits), Beclin-1) was increased in normal pigs, while decreased in miniature pigs.
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009
beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)
, beclin 1
, beclin 1 proteinBeclin-1-like protein
, myosin-like BCL2 interacting protein
, ATG6 autophagy related 6 homolog
, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
, beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
, coiled-coil myosin-like BCL2-interacting protein
, Bcl-2-interacting protein beclin
, coiled-coil, myosin-like BCL2-interacting protein
, beclin 1 (coiled-coil, myosin-like BCL2-interacting protein)
, autophagy-related protein 6