TNFSF12 Proteine (TNFSF12)

Bezeichnung:
Tumor Necrosis Factor (Ligand) Superfamily, Member 12 Proteine (TNFSF12)
Auf www.antikoerper-online.de finden Sie aktuell 32 Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) Proteine von 11 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TNFSF12 Antikörper (145) und TNFSF12 Kits (32) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 218 TNFSF12 Produkte verfügbar.
Synonyme:
Apo3l, Dr3l, Dr3lg, Tweak
alle Proteine anzeigen Gen GeneID UniProt
TNFSF12 8742 O43508
TNFSF12 21944 O54907
TNFSF12 360548  

Weitere Synonyme anzeigen

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Am meisten referenzierte TNFSF12 Proteine

  1. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN2666450 : Bover, Cardó-Vila, Kuniyasu, Sun, Rangel, Takeya, Aggarwal, Arap, Pasqualini: A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. in Journal of immunology (Baltimore, Md. : 1950) 2007 (PubMed)
    Zeige alle 7 Referenzen für 2666450

  2. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN2667599 : Chicheportiche, Bourdon, Xu, Hsu, Scott, Hession, Garcia, Browning: TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. in The Journal of biological chemistry 1998 (PubMed)
    Zeige alle 6 Referenzen für 2667599

  3. Mouse (Murine) TNFSF12 Protein expressed in Human Cells - ABIN2007454 : Campbell, Michaelson, Burkly, Putterman: The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. in Frontiers in bioscience : a journal and virtual library 2004 (PubMed)
    Zeige alle 2 Referenzen für 2007454

  4. Rat (Rattus) TNFSF12 Protein expressed in Human Cells - ABIN2009223 : Lynch, Wang, Lund, Chen, Leal, Wiley: TWEAK induces angiogenesis and proliferation of endothelial cells. in The Journal of biological chemistry 1999 (PubMed)
    Zeige alle 2 Referenzen für 2009223

  5. Human TNFSF12 Protein expressed in Escherichia coli (E. coli) - ABIN935856 : Han, Mekasha, Ingalls: Fibroblast growth factor-inducible 14 (Fn14) is expressed in the lower genital tract and may play a role in amplifying inflammation during infection. in Journal of reproductive immunology 2010 (PubMed)

Weitere Proteine zu TNFSF12 Interaktionspartnern

Human Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) Interaktionspartner

  1. Plasma TWEAK levels do not reflect disease activity or the grade of inflammation in patients with newly diagnosed inflammatory bowel disease.

  2. TWEAK may contribute to the pathogenesis of BP by reducing BP180 (zeige COL17A1 Proteine) expression and cellular adherence, involving the activation of ERK (zeige EPHB2 Proteine) and NF-kappaB (zeige NFKB1 Proteine) pathways. TWEAK may serve as a biomarker or therapeutic target of BP.

  3. TWEAK upregulated the expression of Fn14 (zeige TNFRSF12A Proteine).

  4. Fn14 (zeige TNFRSF12A Proteine) plays a protective role during the acute stages of intestinal inflammation, and its absence promotes the development of colitis-associated cancer.

  5. Fn14 (zeige TNFRSF12A Proteine).TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK which induces lymphoblast apoptosis.

  6. Data show that aurintricarboxylic acid (ATA) targets the TNF-related WEAK inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (zeige DDX3X Proteine) (Fn14 (zeige TNFRSF12A Proteine)) signaling axis, which could potentially be developed as a new therapeutic agent for treatment of glioblastoma (GBM) patients.

  7. soluble Fn14 (zeige TNFRSF12A Proteine) may serve as a potential biomarker for both acute and chronic kidney diseases.

  8. The result of transwell assay revealed that TWEAK promoted LX-2 migration. Subsequently, our data testified that the expression and activity of MMP9 (zeige MMP9 Proteine) was induced by TWEAK in LX-2 cells, which enhanced the migration. Furthermore, our findings showed that TWEAK upregulated the phosphorylation of IkappaBalpha (zeige NFKBIA Proteine) and p65 (zeige GORASP1 Proteine) protein to increase MMP9 (zeige MMP9 Proteine) expression in LX-2 cells.

  9. In this review article, we summarize studies indicating that (i) Fn14 (zeige TNFRSF12A Proteine) gene expression is low in normal brain tissue but is upregulated in advanced brain cancers and, in particular, in GB tumors ; TWEAK: Fn14 (zeige TNFRSF12A Proteine) engagement as well as Fn14 (zeige TNFRSF12A Proteine) overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in vitro.

  10. Findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-beta1 (zeige TGFB1 Proteine) signaling pathway, and phosphorylation of Smad2 (zeige SMAD2 Proteine) and p38 MAPK (zeige MAPK14 Proteine) proteins was also involved in this signaling pathway.

Mouse (Murine) Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) Interaktionspartner

  1. These results implicate TWEAK as a potential molecular target for treatment or prevention of inflammatory arthritis and autoimmune diseases such as rheumatoid arthritis.

  2. soluble Fn14 (zeige TNFRSF12A Proteine) may serve as a potential biomarker for both acute and chronic kidney diseases.

  3. Findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-beta1 (zeige TGFB1 Proteine) signaling pathway, and phosphorylation of Smad2 (zeige SMAD2 Proteine) and p38 MAPK (zeige MAPK14 Proteine) proteins was also involved in this signaling pathway.

  4. TWEAK/Fn14 (zeige TNFRSF12A Proteine) signaling represses PGC-1alpha expression during acute kidney injury through activation of canonical NF-kappaB (zeige NFKB1 Proteine) pathways and epigenetic mechanisms including histone deacetylation on NF-kappaB (zeige NFKB1 Proteine)-binding sites.

  5. These findings suggest that TWEAK signaling might be an aspect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine -mediated neuropathology and be involved in the overall neurodegenerative pathology of Parkinson's disease

  6. results revealed that TWEAK and Fn14 (zeige TNFRSF12A Proteine) are expressed by uterine natural killer cells in pregnant mice

  7. studies show that signaling via TWEAK is deleterious to muscle in RNA toxicity and support the demonstrated utility of anti-TWEAK therapeutics.

  8. During ischaemia, soluble CD163 (zeige CD163 Proteine) functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch (zeige NOTCH1 Proteine) signalling necessary for myogenic progenitor cell proliferation.

  9. TWEAK/Fn14 (zeige TNFRSF12A Proteine) interactions play an important role in the pathogenesis of neuropsychiatric lupus by increasing the accumulation of inflammatory cells in the choroid plexus, disrupting blood brain barrier integrity, and increasing neuronal damage

  10. Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis

TNFSF12 Protein Überblick

Protein Überblick

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene\; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.

Alternative names and synonyms associated with TNFSF12

  • tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12)
  • tumor necrosis factor (ligand) superfamily, member 12 (Tnfsf12)
  • tumor necrosis factor ligand superfamily member 12 (Tnfsf12)
  • Apo3l Protein
  • Dr3l Protein
  • Dr3lg Protein
  • Tweak Protein

Bezeichner auf Proteinebene für TNFSF12

APO3 ligand , APO3/DR3 ligand , TNF-related WEAK inducer of apoptosis , tumor necrosis factor ligand superfamily member 12 , tumor necrosis factor superfamily member 12 , TNF-related weak inducer of apoptosis

GENE ID SPEZIES
8742 Homo sapiens
100568280 Canis lupus familiaris
21944 Mus musculus
360548 Rattus norvegicus
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