anti-Maus FASL Antikörper für Flow Cytometry

Recommended FASL Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Fas Ligand (TNF Superfamily, Member 6) (FASL) Antikörper
  • fasl
  • FASL
  • FASLG
  • FAS
  • TNFRSF6
  • zgc:162027
  • TNFSF6
  • ALPS1B
  • APT1LG1
  • APTL
  • CD178
  • CD95-L
  • CD95L
  • Fas-L
  • Faslg
  • Tnfsf6
  • gld
  • Apt1Lg1
  • Fasl
  • Fas ligand L homeolog
  • Fas cell surface death receptor
  • Fas ligand
  • Fas ligand (TNF superfamily, member 6)
  • faslg.L
  • FAS
  • FASLG
  • faslg
  • fas
  • Fasl
  • Faslg
Epitop
AA 132-146
26
19
17
16
12
9
9
7
7
6
5
5
5
5
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Maus
421
173
89
36
7
5
5
3
3
2
1
1
Wirt
Hamster
259
176
48
32
29
7
1
Klonalität
Monoklonal
Konjugat
Dieser FASL Antikörper ist unkonjugiert
45
31
27
13
12
12
9
9
9
8
8
8
8
8
7
6
6
3
2
2
2
2
2
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
313
257
124
96
80
75
51
47
28
28
13
11
10
10
7
5
3
2
2
1
1
1
1
1
1
1
Hersteller
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Bilder

Produktnummer ABIN1105951
$ 434.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
14.1097355 ABIN1105946 FACS Biotin Hamster IgG Anmelden zum Anzeigen FLIM58 14
14.1097355 ABIN614579 FACS PE Hamster IgG Anmelden zum Anzeigen MFL4 3
14.1097355 ABIN614573 FACS FITC Hamster IgG Anmelden zum Anzeigen MFL4 3
14.1097355 ABIN1105948 FACS FITC Hamster IgG Anmelden zum Anzeigen FLIM58 14
14.1097355 ABIN1105942 FACS Hamster IgG Anmelden zum Anzeigen FLIM58 14
14.1097355 ABIN2478831 FACS Hamster IgG Anmelden zum Anzeigen MFL4 3
14.1097355 ABIN1176980 BR FACS Armenian Hamster IgG3, kappa Anmelden zum Anzeigen MFL4 11
14.1097355 ABIN4895785 FACS APC Rat IgG1 AA 132-279 Anmelden zum Anzeigen 101624
14.1097355 ABIN447421 FACS FITC Armenian Hamster IgG Anmelden zum Anzeigen MFL4
14.1097355 ABIN2665563 CyTOF FACS IHC Hamster IgG Anmelden zum Anzeigen MFL3 9
14.1097355 ABIN2665564 FACS IF IHC Hamster IgG Anmelden zum Anzeigen MFL4 6
14.1097355 ABIN2660963 FACS Biotin Hamster IgG Anmelden zum Anzeigen MFL3 8
14.1097355 ABIN2663097 FACS PE Hamster IgG Anmelden zum Anzeigen MFL3 9
14.1097355 ABIN2660964 FACS Biotin Hamster IgG Anmelden zum Anzeigen MFL4 6
14.1097355 ABIN2665465 FACS Hamster IgG Anmelden zum Anzeigen MFL3 9
14.1097355 ABIN262443 FACS IHC (p) IHC Mouse IgG2b kappa Anmelden zum Anzeigen Kay-10
14.1097355 ABIN262444 FACS Biotin Mouse IgG2b kappa Anmelden zum Anzeigen Kay-10
14.1097355 ABIN187289 FACS IF WB Rat IgG2a Anmelden zum Anzeigen H11
1 ABIN4310543 FACS IHC IHC (fro) IHC (p) Rat IgM AA 196-220 Anmelden zum Anzeigen A11 10
1 ABIN614575 Func FACS Hamster IgG Anmelden zum Anzeigen MFL4 3

General

Antigen Fas Ligand (TNF Superfamily, Member 6) (FASL) Antikörper
Epitop AA 132-146
(26), (19), (17), (16), (12), (9), (9), (7), (7), (6), (5), (5), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Maus
(421), (173), (89), (36), (7), (5), (5), (3), (3), (2), (1), (1)
Wirt Hamster
(259), (176), (48), (32), (29), (7), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser FASL Antikörper ist unkonjugiert
(45), (31), (27), (13), (12), (12), (9), (9), (9), (8), (8), (8), (8), (8), (7), (6), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS)
(313), (257), (124), (96), (80), (75), (51), (47), (28), (28), (13), (11), (10), (10), (7), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-FASL Antikörper

Target Details FASL Anwendungsinformationen Handhabung Referenzen für anti-FASL Antikörper (ABIN1105951) Bilder
Sequenz PSTPSEKKEP RSVAH
Spezifität This antibody reacts with mouse FasL of B6, C3H and MRL mice as well as Balb/c and DBA/1 mice. It also detects gld-type mouse FasL mutant by flow cytometric analysis. We have tested the reactivity on flow cytometry using mouse cell line W40LFL, which is overexpressor of mouse FasL extracellular region (See ref. 1) for more information about this cell line).
Kreuzreaktivität (Details) Species reactivity (tested):Mouse
Reinigung Protein A agarose
Immunogen Synthetic peptide corresponding to the amino acids 132-146 of mouse Fas ligand
Klon FLIM4
Isotyp IgG

Target Details FASL

Produktdetails anti-FASL Antikörper Anwendungsinformationen Handhabung Referenzen für anti-FASL Antikörper (ABIN1105951) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD178 / Fas Ligand (FASL Antibody Abstract)
Hintergrund Fas ligand (FasL/CD178/CD95L) is a type II-membrane protein, whose N terminus is in the cytoplasm and its C-terminal region extends into the extracellular space. Its receptor Fas, also termed Apo-1 or CD95, is a cell-surface type I-membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family. It is known that engagement of Fas by FasL results in apoptotic cell death. Binding of a trimeric FasL to Fas induces trimerization of Fas, and FADD/MORT1 binds to the trimerized Fas cytoplasmic region through the interaction of the respective death domains. Caspase-8 is then recruited to FADD/MORT1 through binding of each death effector domains (DED), which in turn may induce self-activation of the protease domain and eventually leads cell to apoptosis. FasL is predominantly expressed in activated T lymphocytes and Natural Killer (NK) cells, although it is expressed in the tissues of the immune-privilege sites such as the testis and eye. Furthermore, a variety of cancers such as melanomas were found to express FasL in addition to Fas. On the other hand, Fas is expressed in various tissues with abundant expression in the thymus, liver, heart, and kidney. It is reported that Fas/FasL system is involved in the deletion of activated or autoreactive T and B cells. Mature T cells of normal mice are known to die, after they accomplish their tasks. On the contrary, mature T cells from lpr and gld mice, which are deficient of Fas and FasL respectively, do not die after activation, and activated cells accumulate in the lymph nodes and spleens of these mice. Moreover T cell hybridomas activated in the presence of Fas-neutralizing molecule, do not die. In addition to T cells, the Fas-deficient mice accumulate B cells and have elevated levels of immunoglobulins (Ig) of various classes that include anti-ssDNA and anti-dsDNA antibodies. FasL can be used as an immune-suppressive agent. Rejection of transplants is mediated by activated T cells that may express functional Fas. If a transplanted tissue is engineered to express FasL or is co-transplanted with FasL expressing cells, the transplant may be tolerated. Also Fas/ FasL system has been shown to play a role in human diseases such as fulminant hepatitis, AIDS, cancers and other diseases involving CTL-induced tissue destruction.Synonyms: APT1LG1, APTL, Apoptosis antigen ligand, CD95L protein, FASL, FASLG, Fas antigen ligand, TNFSF6, Tumor necrosis factor ligand superfamily member 6
Gen-ID 356
NCBI Accession NP_000630
UniProt P48023
Forschungsgebiet CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Anwendungsinformationen

Produktdetails anti-FASL Antikörper Target Details FASL Handhabung Referenzen für anti-FASL Antikörper (ABIN1105951) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-FASL Antikörper Target Details FASL Anwendungsinformationen Referenzen für anti-FASL Antikörper (ABIN1105951) Bilder zurück nach oben
Konzentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Konservierungsmittel Without preservative
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store (in aliquots) at -20 °C.

Referenzen für anti-FASL Antikörper (ABIN1105951)

Produktdetails anti-FASL Antikörper Target Details FASL Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Miwa, Hashimoto, Yatomi, Nakamura, Nagata, Suda: "Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease." in: International immunology, Vol. 11, Issue 6, pp. 925-31, 1999

Waring, Müllbacher: "Cell death induced by the Fas/Fas ligand pathway and its role in pathology." in: Immunology and cell biology, Vol. 77, Issue 4, pp. 312-7, 1999

Zeytun, Hassuneh, Nagarkatti, Nagarkatti: "Fas-Fas ligand-based interactions between tumor cells and tumor-specific cytotoxic T lymphocytes: a lethal two-way street." in: Blood, Vol. 90, Issue 5, pp. 1952-9, 1997

Hueber, Zörnig, Lyon, Suda, Nagata, Evan: "Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis." in: Science (New York, N.Y.), Vol. 278, Issue 5341, pp. 1305-9, 1997

Kayagaki, Yamaguchi, Nagao, Matsuo, Maeda, Okumura, Yagita: "Polymorphism of murine Fas ligand that affects the biological activity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3914-9, 1997

Bilder

Produktdetails anti-FASL Antikörper Target Details FASL Anwendungsinformationen Handhabung Referenzen für anti-FASL Antikörper (ABIN1105951) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 132-146) antibody (ABIN1105951) anti-Fas Ligand (TNF Superfamily, Member 6) (FASL) (AA 132-146) antibody