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PPP1R12A Antikörper (AA 723-840)

PPP1R12A Reaktivität: Human, Maus, Ratte WB Wirt: Maus Monoclonal 20-MYPT1 unconjugated
Produktnummer ABIN968768
  • Target Alle PPP1R12A Antikörper anzeigen
    PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
    Bindungsspezifität
    • 27
    • 23
    • 7
    • 7
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 723-840
    Reaktivität
    • 94
    • 81
    • 68
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 111
    • 2
    • 1
    Maus
    Klonalität
    • 112
    • 2
    Monoklonal
    Konjugat
    • 51
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PPP1R12A Antikörper ist unkonjugiert
    Applikation
    • 59
    • 26
    • 26
    • 26
    • 17
    • 13
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat MYPT1 aa. 723-840
    Klon
    20-MYPT1
    Isotyp
    IgG1
    Top Product
    Discover our top product PPP1R12A Primärantikörper
  • Kommentare

    Related Products: ABIN968545, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Khatri, Joyce, Brozovich, Fisher: "Role of myosin phosphatase isoforms in cGMP-mediated smooth muscle relaxation." in: The Journal of biological chemistry, Vol. 276, Issue 40, pp. 37250-7, (2001) (PubMed).

    Kimura, Ito, Amano, Chihara, Fukata, Nakafuku, Yamamori, Feng, Nakano, Okawa, Iwamatsu, Kaibuchi: "Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)" in: Science (New York, N.Y.), Vol. 273, Issue 5272, pp. 245-8, (1996) (PubMed).

    Chen, Chen, Alessi, Campbell, Shanahan, Cohen, Cohen: "Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M." in: FEBS letters, Vol. 356, Issue 1, pp. 51-5, (1995) (PubMed).

  • Target
    PPP1R12A (Myosin Phosphatase, Target Subunit 1 (PPP1R12A))
    Andere Bezeichnung
    MYPT1 (PPP1R12A Produkte)
    Synonyme
    1200015F06Rik antikoerper, 5730577I22Rik antikoerper, AA792106 antikoerper, AV099298 antikoerper, D10Ertd625e antikoerper, Mypt1 antikoerper, M130 antikoerper, MBS antikoerper, MYPT1 antikoerper, M110 antikoerper, MBSP antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 12A antikoerper, protein phosphatase 1 regulatory subunit 12A antikoerper, protein phosphatase 1, regulatory subunit 12A antikoerper, Ppp1r12a antikoerper, PPP1R12A antikoerper
    Hintergrund
    Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that is involved in various cellular processes in eukaryotic cells. The PP1 catalytic subunit may be directed to particular subcellular locations by targeting subunits, which can modify the substrate specificity of the enzyme. The PP1 enzyme associated with the myofibrils of striated and smooth muscle forms a complex with Myosin Phosphatase Targeting subunit 1 (MYPT1). MYPT1 contains seven ankyrin repeats in the N-terminal region, and a leucine zipper (LZ) motif in the C-terminus. Alternative splicing of the MYPT1 mRNA leads to expression of a truncated MYPT1 that lacks the leucine zipper region. The expression of MYPT1 splice variants correlate with a smooth muscle phenotype. In the tonic contracting chicken aorta, only the full length MYPT1 is expressed, while in the phasic contracting chicken gizzard, only the truncated MYPT1 is expressed. The leucine zipper motif may be required for association with cGMP-dependent protein kinase I. Thus, MYPT1 may direct not only PP1 enzymatic activity toward myosin, but also may regulate the cGMP responsiveness of PP1 through expression of alternative splice variants.
    Synonyms: Myosin Phosphatase Targeting subunit 1
    Molekulargewicht
    130 kDa
    Pathways
    M Phase
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