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TJP1 Antikörper (AA 1048-1247)

TJP1 Reaktivität: Human WB, IF Wirt: Maus Monoclonal 1-ZO unconjugated
Produktnummer ABIN968282
  • Target Alle TJP1 Antikörper anzeigen
    TJP1 (Tight Junction Protein 1 (TJP1))
    Bindungsspezifität
    • 16
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1048-1247
    Reaktivität
    • 54
    • 32
    • 30
    • 20
    • 18
    • 9
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 49
    • 3
    • 3
    • 1
    • 1
    Maus
    Klonalität
    • 51
    • 6
    Monoklonal
    Konjugat
    • 39
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TJP1 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 20
    • 18
    • 15
    • 14
    • 13
    • 12
    • 12
    • 11
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human ZO-1 aa. 1048-1247
    Klon
    1-ZO
    Isotyp
    IgG1
    Top Product
    Discover our top product TJP1 Primärantikörper
  • Kommentare

    Related Products: ABIN968535, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Hirase, Kawashima, Wong, Ueyama, Rikitake, Tsukita, Yokoyama, Staddon: "Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 10423-31, (2001) (PubMed).

    Nix, Chishti, Anderson, Walther: "hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41192-200, (2001) (PubMed).

    Ebnet, Schulz, Meyer Zu Brickwedde, Pendl, Vestweber: "Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27979-88, (2000) (PubMed).

    Willott, Balda, Fanning, Jameson, Van Itallie, Anderson: "The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 16, pp. 7834-8, (1993) (PubMed).

  • Target
    TJP1 (Tight Junction Protein 1 (TJP1))
    Andere Bezeichnung
    ZO-1 (TJP1 Produkte)
    Synonyme
    ZO-1 antikoerper, ZO1 antikoerper, zo1 antikoerper, tight junction protein 1 antikoerper, tight junction protein ZO-1 antikoerper, TJP1 antikoerper, Tjp1 antikoerper, LOC396567 antikoerper
    Hintergrund
    Tight junctions (zonulae occludens) are critical to the maintenance of cell polarity and intracellular barriers between epithelial and endothelial cells. Protein components of the tight junctions include actin filaments, symplekin, occludin, Rab3B, AF-6, 7H6, ZO-1, and ZO-2. Analysis of ZO-1 and -2 resulted in their inclusion in the MAGUK protein family. This family also includes the discs large tumor suppressor protein (Dlg-A) of Drosophila, p55, an erythrocyte membrane protein, and PSD-95/SAP90, a synaptic membrane protein. All family members contain a region homologous to guanylate kinase (GuK), a src homology (SH3) domain, and multiple PDZ domains. Through these elements, MAGUK proteins function in signal transduction and, possibly, tumor suppression. ZO-1 is a peripheral membrane phosphoprotein that binds to other tight junction proteins such as occludin and AF-6. Via its SH3 domain, ZO-1 interacts with a serine protein kinase that phosphorylates a region immediately C-terminal of the SH3 domain. Taken together, these data indicate that ZO-1 is a critical element in the formation of tight junctions and may also serve an important role in signaling and tumor suppression. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    220 kDa
    Pathways
    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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