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TJP1 Antikörper

TJP1 Reaktivität: Human, Maus, Ratte, Schwein WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6266146
  • Target Alle TJP1 Antikörper anzeigen
    TJP1 (Tight Junction Protein 1 (TJP1))
    Reaktivität
    • 54
    • 31
    • 29
    • 19
    • 18
    • 9
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Schwein
    Wirt
    • 48
    • 4
    • 3
    • 1
    • 1
    Kaninchen
    Klonalität
    • 50
    • 7
    Polyklonal
    Konjugat
    • 39
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TJP1 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 20
    • 17
    • 14
    • 14
    • 13
    • 12
    • 12
    • 11
    • 8
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    ZO 1 Antibody detects endogenous levels of total ZO 1
    Kreuzreaktivität
    Human, Maus, Schwein, Ratte (Rattus)
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ZO 1
    Isotyp
    IgG
    Top Product
    Discover our top product TJP1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Wang, Lu, Xie, Xiong, Huang, Wei, Jiang, Peng: "Blend of organic acids and medium chain fatty acids prevents the inflammatory response and intestinal barrier dysfunction in mice challenged with enterohemorrhagic Escherichia coli O157:H7." in: International immunopharmacology, Vol. 58, pp. 64-71, (2018) (PubMed).

    Zou, Xiang, Wang, Peng, Wei: "Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model." in: BioMed research international, Vol. 2016, pp. 5436738, (2017) (PubMed).

  • Target
    TJP1 (Tight Junction Protein 1 (TJP1))
    Andere Bezeichnung
    ZO 1 (TJP1 Produkte)
    Synonyme
    ZO-1 antikoerper, ZO1 antikoerper, zo1 antikoerper, tight junction protein 1 antikoerper, tight junction protein ZO-1 antikoerper, TJP1 antikoerper, Tjp1 antikoerper, LOC396567 antikoerper
    Hintergrund

    Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).

    Gene: TJP1

    Molekulargewicht
    195 kDa
    Gen-ID
    7082
    UniProt
    Q07157
    Pathways
    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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