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RIPK1 Antikörper

RIPK1 Reaktivität: Human WB, IP Wirt: Maus Monoclonal G322-2 unconjugated
Produktnummer ABIN967308
  • Target Alle RIPK1 Antikörper anzeigen
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Reaktivität
    • 90
    • 41
    • 30
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 84
    • 13
    Maus
    Klonalität
    • 75
    • 22
    Monoklonal
    Konjugat
    • 41
    • 9
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RIPK1 Antikörper ist unkonjugiert
    Applikation
    • 66
    • 33
    • 22
    • 15
    • 14
    • 13
    • 13
    • 12
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    truncated RIP fusion protein
    Klon
    G322-2
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product RIPK1 Primärantikörper
  • Applikationshinweise
    Additional control lysate (ABIN968537) is sold separately.
    Kommentare

    Related Products: ABIN968537

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Stanger, Leder, Lee, Kim, Seed: "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death." in: Cell, Vol. 81, Issue 4, pp. 513-23, (1995) (PubMed).

  • Target
    RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
    Andere Bezeichnung
    RIP (RIPK1 Produkte)
    Synonyme
    RIP antikoerper, RIP1 antikoerper, D330015H01Rik antikoerper, Rinp antikoerper, Rip1 antikoerper, rip1 antikoerper, ripk1 antikoerper, xRIP1beta antikoerper, xrip1 antikoerper, receptor interacting serine/threonine kinase 1 antikoerper, receptor (TNFRSF)-interacting serine-threonine kinase 1 antikoerper, receptor interacting serine/threonine kinase 1 L homeolog antikoerper, RIPK1 antikoerper, Ripk1 antikoerper, ripk1.L antikoerper
    Hintergrund
    RIP (receptor interacting protein) is a 74 kDa serine/threonine kinase which may be recruited to TNFR type 1 and Fas (CD95) receptor signal complexes following ligand binding. RIP interacts with other signal proteins within these complexes (e.g., RAIDD) and has also been shown to interact with pro-caspase-2. RIP contains an N-terminal kinase domain as well as a C-terminal death domain that is homologous to intracellular death domain of Fas. Over expression of RIP in vitro is sufficient to induce cell death, demonstrating that RIP functions as an apoptosis-inducing protein. Interaction of the Fas death domain with other intracellular proteins like RIP is an important step leading to downstream components in apoptotic signaling pathways. Clone G322-2 recognizes human RIP. A recombinant truncated human RIP:tagged fusion protein, lacking the kinase domain of RIP, was used as immunogen. The specificity of the antibody was verified by ELISA, immunoprecipitation and western blot analysis. The antibody is routinely tested by western blot analysis in human Jurkat T cells where it recognizes RIP as a 74 kDa band. Smaller molecular weight breakdown bands of ~30 kDa, 22 kDa, and/or 16 kDa are sometimes observed.
    Molekulargewicht
    74 kDa
    Pathways
    NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom, Ubiquitin Proteasome Pathway
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